4 Dokumente gefunden
Genetic Variants as Predictors of the Success of Colorectal Cancer Treatments
Background Some genetic polymorphisms (SNPs) have been proposed as predictors for different colorectal cancer (CRC) outcomes. This work aims to assess their performance in our cohort and find new SNPs associated with them. Methods A total of 833 CRC cases were analyzed for seven outcomes, including the…
Basel: MDPI AG, 2023
Mendelian randomisation shows diverticular disease and irritable bowel syndrome increase the risk of haemorrhoidal disease
Recently in Gut, Zhu and colleagues1 investigated causality of genetic risk effects across three genetically correlated conditions: haemorrhoidal disease (HEM), diverticular disease (DIV) and IBS. Using genome-wide association study (GWAS) summary statistics from our previous HEM GWAS2 and other studies,3–5…
London: BMJ Publishing Group, 2023
Performance of the Use of Genetic Information to Assess the Risk of Colorectal Cancer in the Basque Population
The risk of developing colorectal cancer (CRC) is partially associated with genetics. Different studies have provided valuable genetic information to understand the biology behind CRC and to build models of genetic risk. However, the study of the applicability of such genetic information within the Basque…
Basel: MDPI AG, 2022
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study (GWAS) meta-analysis to identify genetic risk factors for HEM…
London: BMJ, 2021