2 Dokumente gefunden
Impact of the MCT1-mediated lactate import on the phenotype of pancreatic ductal adenocarcinoma cells
One of the emerging phenotypes during metabolic reprogramming in cancers is the aggressive reverse Warburg phenotype, which correlates with poor prognosis in PDAC. A major metabolic driver of this phenotype is lactate, the highly abundant end product of glycolysis during Warburg metabolism. Lactate can…
Inflammation Associated Pancreatic Tumorigenesis : Upregulation of Succinate Dehydrogenase (Subunit B) Reduces Cell Growth…
Pancreatic ductal adenocarcinoma (PDAC) is amongst the most fatal malignancies and its development is highly associated with inflammatory processes such as chronic pancreatitis (CP). Since the succinate dehydrogenase subunit B (SDHB) is regarded as tumor suppressor that is lost during cancer development,…
Basel: MDPI AG, 2019