Satoshi Orimo

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Papers by Satoshi Orimo

Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication

Acta Neuropathologica

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Quantitative correlation between cardiac MIBG uptake and remaining axons in the cardiac sympathetic nerve in Lewy body disease

Journal of neurology, neurosurgery, and psychiatry, Jan 2, 2015

Reduced cardiac meta-iodobenzylguanidine (MIBG) uptake and loss of cardiac sympathetic axons, as ... more Reduced cardiac meta-iodobenzylguanidine (MIBG) uptake and loss of cardiac sympathetic axons, as its possible anatomical substrate, were both recognised in Lewy body disease (LBD), while their direct correlation has so far remained speculative. Increasing availability of autopsy-confirmed cases of LBD prompted us to quantify residual cardiac sympathetic axons to establish their relationship to cardiac MIBG uptake. We collected cardiac tissue samples from 23 patients with autopsy-confirmed LBD and two non-LBD control patients who underwent (123)I-MIBG cardiac scintigraphy in life. Samples of the left ventricular anterior wall were stained with anti-tyrosine hydroxylase (TH) and anti-neurofilament (NF) antibodies as markers of cardiac nerve axons. We quantified the immunolabelled areas and assessed their correlation to standardised heart to mediastinum (H/M) ratios of (123)I-MIBG cardiac scintigraphy. Cardiac MIBG uptake in the early and delayed phases was reduced in 90.9% and 95.7% o...

A novel WDR45 mutation in a patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)

American journal of medical genetics. Part A, 2014

Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA) is an X-linked dom... more Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA) is an X-linked dominant neurodegenerative disorder, and is classified as a subtype of neurodegeneration with brain iron accumulation. Recently, de novo heterozygous mutations in WDR45 at Xp11.23 have been reported in patients with SENDA. We report the clinical and neuroradiological findings of a patient with SENDA with a novel c.322del mutation in WDR45. In this patient, characteristic MRI findings were useful for diagnosis.

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High-intensity laser-driven particle and electromagnetic wave sources for science, industry, and medicine

Frontiers of Optoelectronics in China, 2009

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[A useful marker for differential diagnosis of Parkinson's disease--MIBG myocardial scintigraphy]

Rinshō shinkeigaku = Clinical neurology, 2004

We performed [123I]-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in 180 patients with ... more We performed [123I]-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in 180 patients with PD, 24 patients with DLB and 73 patients with the other related diseases. The heart-to-mediastinum (H/M) ratio in PD and DLB was significantly low compared to that in MSA, PSP, CBD and AD. The H/M ratio tended to decrease with the disease progression in PD. These findings suggest that MIBG myocardial scintigraphy could be a marker for differential diagnosis of PD and DLB. We immunohistochemically examined heart tissues from patients with pathologically confirmed PD, DLB and the other related diseases using monoclonal antibody against tyrosine hydroxylase (TH). The number of TH-immunoreactive nerve fibers in the epicardium was moderate or abundant in most patients with MSA, PSP, CBD and AD as well as in the control subjects. Contrarily, the number of TH-immunoreactive nerve fibers in the epicardium had almost completely disappeared in nearly all the patients with PD and DLB. These finding...

Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study

by Seigo Nakano, Satoshi Orimo, and Takahiko Tokuda

PloS one, 2015

Dementia with Lewy bodies (DLB) needs to be distinguished from Alzheimer's disease (AD) becau... more Dementia with Lewy bodies (DLB) needs to be distinguished from Alzheimer's disease (AD) because of important differences in patient management and outcome. Severe cardiac sympathetic degeneration occurs in DLB, but not in AD, offering a potential system for a biological diagnostic marker. The primary aim of this study was to investigate the diagnostic accuracy, in the ante-mortem differentiation of probable DLB from probable AD, of cardiac imaging with the ligand 123I-meta-iodobenzylguanidine (MIBG) which binds to the noradrenaline reuptake site, in the first multicenter study. We performed a multicenter study in which we used 123I-MIBG scans to assess 133 patients with clinical diagnoses of probable (n = 61) or possible (n = 26) DLB or probable AD (n = 46) established by a consensus panel. Three readers, unaware of the clinical diagnosis, classified the images as either normal or abnormal by visual inspection. The heart-to-mediastinum ratios of 123I-MIBG uptake were also calcul...

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[Dementia: progress in diagnosis and treatment: Topics, II. Diagnosis; 2. Neuroimaging diagnosis of dementia (MRI SPECT and PET)]

by Takahiko Tokuda and Satoshi Orimo

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, Jan 10, 2011

[A case of 53-years-old woman with the onset of subacute right-sided numbness, and presented with various lesions on MRI]

Nō to shinkei = Brain and nerve

A reply to Treglia et al

Parkinsonism & Related Disorders, 2012

Relationship between Neural Rhythm Generation Disorders and Physical Disabilities in Parkinson’s Disease Patients’ Walking

PLoS ONE, 2014

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Lewy pathology in an autopsy case of FTLD-MND with reduced cardiac MIBG uptake and depletion of cardiac sympathetic fibers

Parkinsonism & Related Disorders, 2013

123I-MIBG myocardial scintigraphy for differentiating Parkinson’s disease from other neurodegenerative parkinsonism: A systematic review and meta-analysis

Parkinsonism & Related Disorders, 2012

Differential diagnosis of Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#... more Differential diagnosis of Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (PD) and other neurodegenerative parkinsonism by clinical consensus criteria and diagnostic imaging is often difficult. (123)I-meta-iodobenzylguanidine ((123)I-MIBG) myocardial scintigraphy is a useful imaging tool for differentiating PD from other parkinsonism. The purpose of the present study is to systematically review and perform a meta-analysis of studies on the diagnostic performance of (123)I-MIBG myocardial scintigraphy for the differential diagnosis of PD and other neurodegenerative parkinsonism, specifically multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. A computer literature search of the PubMED/MEDLINE database was conducted to find relevant published articles on (123)I-MIBG myocardial scintigraphy for the differential diagnosis of PD and other neurodegenerative parkinsonism. We used the bivariate random-effects model to obtain the pooled estimates of the sensitivity and specificity and the corresponding 95% confidence intervals. Thirteen studies comprising 845 patients including 625 PD and 220 other neurodegenerative parkinsonism were analyzed. The pooled sensitivity and specificity to differentiate PD from other neurodegenerative parkinsonism by the early heart-to-mediastinum (H/M) ratio were 82.6% and 89.2%, respectively, and those by the delayed H/M ratio were 89.7% and 82.6%, respectively. When PD was limited to early stage (Hoehn-Yahr stage 1 or 2), the pooled sensitivity and specificity by the delayed H/M ratio were 94.1% and 80.2%, respectively. The present meta-analysis confirmed high sensitivity and specificity of (123)I-MIBG myocardial scintigraphy for differentiating PD from other neurodegenerative parkinsonism in both early and delayed imaging phases. Furthermore, (123)I-MIBG myocardial scintigraphy was highly effective for distinguishing early PD.

Myocardial nerve fibers are preserved in MPTP-treated mice, despite cardiac sympathetic dysfunction

Neuroscience Research, 2008

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Immunohistochemical analysis of perforin and granzyme A in inflammatory myopathies

Neuromuscular Disorders, 1994

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Inflammatory response in facioscapulohumeral muscular dystrophy (FSHD): Immunocytochemical and genetic analyses

Muscle & Nerve, 1995

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Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2

Movement Disorders, 2005

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Single-Shot Creation of Nanometer-Sized Silicon Tadpoles by Ultrahigh-Intensity Laser

Japanese Journal of Applied Physics, 2004

The single-shot creation of tadpolelike silicon nanoparticles constructed with multi-crystalline ... more The single-shot creation of tadpolelike silicon nanoparticles constructed with multi-crystalline heads and amorphous tails by a high brightness fs-pulse laser was demonstrated. This is also the first demonstration of the creation of a nanosized connection of multicrystalline silicon with amorphous silicon. This result should expand the creation of new materials by a laser ablation using a high-intensity fs laser, and

[123I] Meta-iodobenzylguanidine Myocardial Scintigraphy Differentiates Corticohasal Degeneration from Parkinson's Disease

Internal Medicine, 2003

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Degeneration of Cardiac Sympathetic Nerve Begins in the Early Disease Process of Parkinson?s Disease

Brain Pathology, 2007

Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [(123)I] MIBG myocardial scintigra... more Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [(123)I] MIBG myocardial scintigraphy has been reported in the early stages of Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (PD), which suggests involvement of the cardiac sympathetic nerve in the early disease process of PD. For confirmation, we immunohistochemically examined cardiac tissue, sympathetic ganglia and medulla oblongata of 20 patients with incidental Lewy body disease (ILBD), which is thought to be a presymptomatic stage of PD, and 10 control subjects, using antibodies against tyrosine hydroxylase (TH) and neurofilament (NF). Immunoreactive nerve fibers of fascicles in the epicardium were well preserved in 10 of the 20 patients with ILBD and in the control subjects. In contrast, TH-immunoreactive nerve fibers had nearly disappeared in six subjects and were moderately decreased in four of the 20 patients with ILBD. Neuronal cell loss in the dorsal vagal nucleus and the sympathetic ganglia was not detectable in any of the ILBD patients examined. These findings suggest that degeneration of the cardiac sympathetic nerve begins in the early disease process of PD and that it occurs before neuronal cell loss in the dorsal vagal nucleus.

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High-energy proton generation from thin-foil targets with a high-intensity ultra-short pulse laser

We observe the proton signals with thin-foil polyimide and copper targets with a high-intensity T... more We observe the proton signals with thin-foil polyimide and copper targets with a high-intensity Ti:sapphire laser pulse. High-energy protons with the maximum energy of 2.3 MeV for 7.5 mum thick polyimide target and 1.2 MeV for 3 mum thick copper target are generated at the laser intensity of ~1×1019 W/cm2 under preformed plasma condition.