JAMA: The Journal of the American Medical Association, 1978
History of Organization The Cleveland Vascular Society (CVS) was founded in 1975 by 21 vascular s... more History of Organization The Cleveland Vascular Society (CVS) was founded in 1975 by 21 vascular surgeons drawn from Case Western Reserve University, The Cleveland Clinic, community hospi-tals, and independent practices. It represents the majority of surgeons performing ...
Aspirin and dipyridamole have been used to treat the thromboembolic complications of atherosclero... more Aspirin and dipyridamole have been used to treat the thromboembolic complications of atherosclerosis. We studied the effects of these drugs on the rate of endothelial healing after a standard de-endothelializing injury of the thoracic aorta. Twenty-five rabbits received 13.5 mg/kg/day of aspirin and 15 mg/kg/day of dipyridamole one week before injury and for the period of endothelial regrowth. There were 25 control animals. Mean serum aspirin salicylate levels were 12 micrograms/dL at the time of injury and 15 micrograms/dL at death. Areas of endothelial regrowth were measured by Evans blue dye at 1, 4, 7 and 14 days after injury. The percentage of endothelial regrowth was measured by computer-assisted morphometry. Antiplatelet treatment retarded endothelial regrowth by 66% at four days, 22% at seven days, and 28% at 14 days. Antiplatelet drugs must be used cautiously, as re-endothelialization of injured arteries is retarded.
JAMA: The Journal of the American Medical Association, 1978
History of Organization The Cleveland Vascular Society (CVS) was founded in 1975 by 21 vascular s... more History of Organization The Cleveland Vascular Society (CVS) was founded in 1975 by 21 vascular surgeons drawn from Case Western Reserve University, The Cleveland Clinic, community hospi-tals, and independent practices. It represents the majority of surgeons performing ...
Aspirin and dipyridamole have been used to treat the thromboembolic complications of atherosclero... more Aspirin and dipyridamole have been used to treat the thromboembolic complications of atherosclerosis. We studied the effects of these drugs on the rate of endothelial healing after a standard de-endothelializing injury of the thoracic aorta. Twenty-five rabbits received 13.5 mg/kg/day of aspirin and 15 mg/kg/day of dipyridamole one week before injury and for the period of endothelial regrowth. There were 25 control animals. Mean serum aspirin salicylate levels were 12 micrograms/dL at the time of injury and 15 micrograms/dL at death. Areas of endothelial regrowth were measured by Evans blue dye at 1, 4, 7 and 14 days after injury. The percentage of endothelial regrowth was measured by computer-assisted morphometry. Antiplatelet treatment retarded endothelial regrowth by 66% at four days, 22% at seven days, and 28% at 14 days. Antiplatelet drugs must be used cautiously, as re-endothelialization of injured arteries is retarded.
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Papers by Ralph Depalma