Papers by Pedro C Hidalgo
International Journal of Advertising, 1998
Earthquake Spectra, 1989
Most recent seismic codes include response modification factors in the definition of the equivale... more Most recent seismic codes include response modification factors in the definition of the equivalent lateral forces that are used for the design of earthquake resistant buildings. The response modification factors (R) are used to reduce the linear elastic design spectrum to account for the energy dissipation capacity of the structure. The evaluation of these response modification factors for various sets of earthquake records and ductility factors is presented herein. Special attention is given to the short period range where the reduction of linear elastic response spectra is smaller than the values for intermediate and long period structures. An idealized and simple variation of the response modification factor as a function of the period of vibration, suitable for seismic codes formulation, is also presented.
Arquivos Brasileiros de Cardiologia, 2013
Abstract: Wirelessly interconnected handheld devices allow Collaborative 1: 1, or faceto-face Com... more Abstract: Wirelessly interconnected handheld devices allow Collaborative 1: 1, or faceto-face Computer Supported Collaborative Learning, which has shown to be a technology that fosters collaboration and constructivist learning. Dissemination of the technology has been slow mainly due to the technology cost. To provide Pocket PCs to a whole classroom is beyond emerging markets reach. Mobile phones are an alternative. Users buy them, releasing public money to be invested in the classroom technology. A second alternative ...
American Journal of Human Biology, Jan 25, 2023
Uruguay has one of the highest per capita milk intakes worldwide, even with a limited supply of l... more Uruguay has one of the highest per capita milk intakes worldwide, even with a limited supply of lactose‐free products; furthermore, the admixed nature of its population is well known, and various frequencies of lactase persistence (LP) are observed in the source populations. We aimed to contribute to the understanding of the relation between allelic variants associated with LP, milk consumption, digestive symptoms, and genetic ancestry in the Uruguayan population. Samples of saliva or peripheral blood were collected from 190 unrelated individuals from two regions of Uruguay, genotypes for polymorphic sites in a fragment within the LCT enhancer were determined and allelic frequencies calculated in all of them. Data were collected on frequency of milk and dairy consumption and self‐reported symptoms in a subsample of 153 individuals. Biparental and maternal ancestry was determined by analyzing individual ancestry markers and mitochondrial DNA. Twenty‐nine percentage of individuals reported symptoms attributed to the ingestion of fresh milk, with abdominal pain, bloating and flatulence being the most frequent. European LP‐associated allele T‐13910 showed a frequency of 33%, while other LP‐associated alleles like G‐13915 and T‐14011 were observed in very low frequencies. Associations between self‐reported symptoms, fresh milk intake, and C/T‐13910 genotype were statistically significant. No evidence of association between genetic ancestry and C/T‐13910 was found, although individuals carrying one T‐13910 allele appeared to have more European ancestry. In conclusion, the main polymorphism capable of predicting lactose intolerance in Uruguayans is C/T‐13910, although more studies are required to unravel the relation between genotype and lactase activity, especially in heterozygotes.
American Journal of Human Biology
BackgroundWith regard to the origin of its population and microevolutionary processes, Uruguay ex... more BackgroundWith regard to the origin of its population and microevolutionary processes, Uruguay exhibits distinctive features that distinguish it from other countries in Latin America, while at the same time sharing several similarities. In this article, we will focus on the variability of paternal genetic lineages in two geographical regions with different histories that can be considered as examples of distinct populations for the continent. In general terms, the genetic diversity is a result of different demographic processes related to the American conquest and colonisation. These resulted in distinct ancestral components which vary geographical and depend on the distribution by sex within these components. In Uruguay, native maternal haplogroups are significantly more frequent in the North. Although there are several studies about the geneticvariability of Uruguay, little is known about male genetic lineages.AimsThe aim of this work is to present an updated study of the male gen...
Journal of Energy and Power Technology
Hybrid composites based on inorganic nanomaterials embedded into a polymer matrix have were synth... more Hybrid composites based on inorganic nanomaterials embedded into a polymer matrix have were synthesized and characterized. Oxide semiconductor nanoparticles (SnO, SnO2, TiO2, Ga2O3, and NiO) and Si nanoparticles were employed as inorganic counterparts in the hybrid composite, while a conductive polymer (PEDOT:PSS) with diverse additives was used as the organic matrix. The composites were spin-coated on Si or glass substrates. The potential use of these materials in photovoltaic devices to improve Si surface passivation behavior was investigated. Besides, the use of the nanoparticles as active materials for anodes in Li-ion batteries was evaluated. Some other aspects, such as the durability and stability of these materials, were also assessed.
HLA-A, -B, -DR en receptores de trasplante HLA-A, -B, -DR en receptores de trasplante HLA-A, -B, -DR en receptores de trasplante HLA-A, -B, -DR en receptores de trasplante HLA-A, -B, -DR en receptores de trasplante de médula ósea en Uruguay ResumenIntroduccion: Uruguay posee un sistema solidario de financiacion de trasplante a traves de... more ResumenIntroduccion: Uruguay posee un sistema solidario de financiacion de trasplante a traves delFondo Nacional de Recursos y del Banco Nacional de Organos y Tejidos (BNOT).En el trasplante alogenico de medula osea la compatibilidad HLA es una barrera biologicaimportante. Las frecuencias alelicas y haplotipicas HLA son utilizadas para determinar laprobabilidad de encontrar un donante con un fenotipo particular HLA y para predecir elefecto de diversos esquemas de adjudicacion basados en la compatibilidad en este sistema. ElLaboratorio de Inmunogenetica e Histocompatibilidad tipifica a todos los receptores ydonantes del pais. En este marco se ha iniciado un programa cuyo objetivo central esorganizar un sistema de registro, tipificacion y busqueda de donantes no relacionados a nivelnacional (SINDOME).Los objetivos del presente trabajo han sido analizar los receptores tipificados para TMOalogenico en nuestro servicio en el periodo enero 1997 - mayo 2002, y caracterizar laconstitucion g...
Archivos de Pediatría del Uruguay, 2020
Sangre, 1995
A total number of 1,149 specimens of cord-blood were subjected to cellulose acetate gel electroph... more A total number of 1,149 specimens of cord-blood were subjected to cellulose acetate gel electrophoresis in order to estimate the incidence of haemoglobinopathies in newborn infants (NBI). It was found that 4.37% of black NBI and 0.54% of white NBI were AS carriers. Those samples with HbS or HbC were verified by means of agar-citrate electrophoresis at pH 6.2. Haemoglobin Bart was commonest in black (3.1%) than in white (0.4%) NBI. A slow haemoglobin variant was found with an alpha-chain mutation. The concentration of gamma G was estimated by separation of gamma G and gamma A chains with polyacrylamide gel electrophoresis, and it ranged between 52% and 94%, which could be attributed to the fact that the shift from HbF to HbA is not simultaneous in all the red-cell population.
Sangre, 1999
To evaluate the catalytic activity of the red cell enzyme, glutathione reductase (GR) in pregnant... more To evaluate the catalytic activity of the red cell enzyme, glutathione reductase (GR) in pregnant women with Hb AS and with Hb AA, and in a group of non-pregnant women with Hb AA, as well as the relationship of GR deficiency with Hb S. The catalytic activity was determined in presence and absence of FAD by means of a modified Long and Carson technique. 59 pregnant women with AS and 33 with AA phenotypes were studied. Differences were found in the enzyme's catalytic activity with and without FAD, both in pregnant women with Hb AS (mean values 37.17 nka/g y Hb in whites and 42.84 nkat/g HS in afro people) and in those with Hb AA, and also in non-pregnant women with Hb AA. A high frequency of GR deficiency was found in all groups due to an insufficient riboflavin supply in diet. A correlation between GR deficiency and Hb S could not be demonstrated. The coefficient of activity of red cell GR shows a tendency to increase in pregnancy due to certain riboflavin deficit of diet.
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Papers by Pedro C Hidalgo