Papers by Meir Israelowitz
Computational modeling of type I collagen fibers to determine the extracellular matrix
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Europe Patent , 2022
The present invention relates to a detector, a device and a method for imaging infrared (IR) and/... more The present invention relates to a detector, a device and a method for imaging infrared (IR) and/or microwave irradiation, and to a method for producing the detector and the device. The device is set up to select at least two different wavelengths of IR irradiation and/or of microwave irradiation from incident irradiation, to move and direct or resp. scan the incident irradiation over a detector, to detect the at least two wavelengths and for each wavelength to generate a separate image. By scanning the incident irradiation over the detector and by overlaying the separate images, the device generates a picture which is sharper and/or has less noise, e.g. in comparison to a picture that can be obtained e.g. by devices that detect only one wavelength. The device can be used as a camera for generating infrared and/or microwave pictures.
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Series in BioEngineering, 2021
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Computational Modeling in Tissue Engineering 10, 2012
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New Journal of Science, 2014
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Series in BioEngineering, 2021
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Series in BioEngineering, 2021
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Series in BioEngineering, 2021
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Series in BioEngineering, 2021
Noise is considered an artefact, in the practical use it is overcome by cool down the system in g... more Noise is considered an artefact, in the practical use it is overcome by cool down the system in general at 77 K. We consider three biological examples which overcome noise by filtering the ratio between the signals and noise by using a distribution system. Noise is considered here in statistical terms poison, where the incident photon or otherwise in a detector and the detector has not influence and cannot increase.
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BioMed Research International, 2015
A three-dimensional computational fluid dynamics- (CFD-) model based on a differential pressure l... more A three-dimensional computational fluid dynamics- (CFD-) model based on a differential pressure laminar flow bioreactor prototype was developed to further examine performance under changing culture conditions. Cell growth inside scaffolds was simulated by decreasing intrinsic permeability values and led to pressure build-up in the upper culture chamber. Pressure release by an integrated bypass system allowed continuation of culture. The specific shape of the bioreactor culture vessel supported a homogenous flow profile and mass flux at the scaffold level at various scaffold permeabilities. Experimental data showed an increase in oxygen concentration measured inside a collagen scaffold seeded with human mesenchymal stem cells when cultured in the perfusion bioreactor after 24 h compared to static culture in a Petri dish (dynamic: 11% O2versus static: 3% O2). Computational fluid simulation can support design of bioreactor systems for tissue engineering application.
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BioResearch Open Access, 2015
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Journal of Healthcare Engineering, 2012
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BioResearch open access, 2012
We present a laminar flow reactor for bone tissue engineering that was developed based on a compu... more We present a laminar flow reactor for bone tissue engineering that was developed based on a computational fluid dynamics model. The bioreactor design permits a laminar flow field through its specific internal shape. An integrated bypass system that prevents pressure build-up through bypass openings for pressure release allows for a constant pressure environment during the changing of permeability values that are caused by cellular growth within a porous scaffold. A macroporous ceramic scaffold, composed of zirconium dioxide, was used as a test biomaterial that studies adipose stem cell behavior within a controlled three-dimensional (3D) flow and pressure environment. The topographic structure of the material provided a basis for stem cell proliferation and differentiation toward the osteogenic lineage. Dynamic culture conditions in the bioreactor supported cell viability during long-term culture and induced cell cluster formation and extra-cellular matrix deposition within the porou...
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Europe Patent Office, 2021
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Journal of Tissue Engineering and Regenerative Medicine 6(Suppl.1, 2012
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Papers by Meir Israelowitz