Papers by Marla R Wolfson
The FASEB Journal, Dec 23, 2019
Science Translational Medicine, 2020
Histone deacetylase inhibition counteracts adverse left ventricular remodeling, improves pulmonar... more Histone deacetylase inhibition counteracts adverse left ventricular remodeling, improves pulmonary function, and reverses diastolic dysfunction.
Proceedings of the National Academy of Sciences, 2019
Significance Our results provide an example of reactivation of a signaling pathway important in e... more Significance Our results provide an example of reactivation of a signaling pathway important in embryogenesis that can be exploited to promote tissue repair and help host recovery from bacterial pneumonia. Although this approach of regenerative medicine will not curtail infection per se, it reduces suffering and shortens recovery time by fostering tissue repair, thus complementing antibiotic treatment and improving patient outcomes from serious infections. Our findings open up a frontier in the treatment of microbial infections using microRNA-based regenerative therapy.
Physical Therapy, 1981
ABSTRACT
The journal of trauma and acute care surgery, Feb 23, 2017
Hemorrhagic shock and pneumonectomy causes an acute increase in pulmonary vascular resistance (PV... more Hemorrhagic shock and pneumonectomy causes an acute increase in pulmonary vascular resistance (PVR). The increase in PVR and right ventricular (RV) afterload leads to acute RV failure, thus reducing left ventricular (LV) preload and output. Inhaled nitric oxide (iNO) lowers PVR by relaxing pulmonary arterial smooth muscle without remarkable systemic vascular effects. We hypothesized that with hemorrhagic shock and pneumonectomy, iNO can be used to decrease PVR and mitigate right heart failure. A hemorrhagic shock and pneumonectomy model was developed using sheep. Sheep received lung protective ventilatory support and were instrumented to serially obtain measurements of hemodynamics, gas exchange, and blood chemistry. Heart function was assessed with echocardiography. After randomization to study gas of iNO 20 ppm (n = 9) or nitrogen as placebo (n = 9), baseline measurements were obtained. Hemorrhagic shock was initiated by exsanguination to a target of 50% of the baseline mean arter...
PloS one, 2016
Permissive hypercapnia has been shown to reduce lung injury in subjects with surfactant deficienc... more Permissive hypercapnia has been shown to reduce lung injury in subjects with surfactant deficiency. Experimental studies suggest that hypercapnic acidosis by itself rather than decreased tidal volume may be a key protective factor. To study the differential effects of a lung protective ventilatory strategy or hypercapnic acidosis on gas exchange, hemodynamics and lung injury in an animal model of surfactant deficiency. 30 anesthetized, surfactant-depleted rabbits were mechanically ventilated (FiO2 = 0.8, PEEP = 7cmH2O) and randomized into three groups: Normoventilation-Normocapnia (NN)-group: tidal volume (Vt) = 7.5 ml/kg, target PaCO2 = 40 mmHg; Normoventilation-Hypercapnia (NH)-group: Vt = 7.5 ml/kg, target PaCO2 = 80 mmHg by increasing FiCO2; and a Hypoventilation-Hypercapnia (HH)-group: Vt = 4.5 ml/kg, target PaCO2 = 80 mmHg. Plasma lactate and interleukin (IL)-8 were measured every 2 h. Animals were sacrificed after 6 h to perform bronchoalveolar lavage (BAL), to measure lung w...
Biomedical instrumentation & technology / Association for the Advancement of Medical Instrumentation
The authors developed a compact gas sampling and perfluorochemical (PFC) measuring system for use... more The authors developed a compact gas sampling and perfluorochemical (PFC) measuring system for use in total and partial liquid ventilation systems, based on a precision two-thermistor thermal detector (TD). They describe the sensitivity and linearity of their on-line method for PFC analysis of expired gases and show how it may be used in partial liquid ventilation studies for determining PFC saturation and loss. Gas is sampled for a short time from a breathing circuit through a heated tube at a selectable point in the breathing cycle. Inspiration is sensed by a pressure transducer. The sample of gas is pulled into the heated (48 degrees C) thermistor chamber by suction and held there while the cooling effect of the vapor changes the thermistor temperature. Dry air in another chamber affects a second thermistor, and the difference of these responses is amplified. The raw signal is corrected for the effects of varying O2 levels by a fuel cell. This signal is sampled and held and displa...
Electroencephalography and Clinical Neurophysiology, 1994
Pediatric and Neonatal Mechanical Ventilation, 2014
Critical care physicians facing patients that require invasive mechanical ventilation are confron... more Critical care physicians facing patients that require invasive mechanical ventilation are confronted with the questions what type of ventilator and what ventilator strategy is most appropriate for this particular patient. Mechanical ventilation is initiated to bridge a gap to recovery or to supply chronic support. Failure of mechanical ventilation can arise through inability to deliver adequate gas exchange or through resulting complications, like pneumothorax. Although mechanical ventilation is meant to support respiratory function, mechanical ventilation can also result in pulmonary damage and contribute to increased risk of mortality. Therefore, the selection of the ventilator type and strategy should be guided by the capacity to achieve adequate gas exchange and, in the meanwhile, to prevent lung injury.
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Papers by Marla R Wolfson