Hernan Pimienta

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Papers by Hernan Pimienta

Neurodegenerative Diversity in human cortical contusion: Histological analysis of tissue derived from decompressive craniectomy

Brain Research, 2013

Caracterización de un modelo organotípico de cultivos de neuronas corticales de humano derivadas de trauma craneoencefálico

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Sistema nervioso: Neuroanatomía funcional y clínica

Este libro presenta una visión integrada de la Neuroanatomía Funcional y la Neuroquímica, describ... more Este libro presenta una visión integrada de la Neuroanatomía Funcional y la Neuroquímica, describiendo el aspecto macroscópico, el microscópico, los circuitos más conocidos, los neurotransmisores y receptores relacionados con ellos. El texto es una herramienta eficaz para el estudio del Sistema Nervioso, el análisis y la formulación de correlaciones básico-clínicas. Es útil para profesionales y estudiantes de medicina, odontología, fisioterapia, fonoaudiología, psicología y para investigadores y especialistas en neurología, neurocirugía, psiquiatría, neuropsicología, neurofisiología, neurofarmacología y neurobiología, entre otras.

Sistema nervioso

Von Economo Neurons in the Human Medial Frontopolar Cortex

Frontiers in neuroanatomy, 2018

The von Economo neurons (VEN) are characterized by a large soma, spindle-like soma, with little d... more The von Economo neurons (VEN) are characterized by a large soma, spindle-like soma, with little dendritic arborization at both, the basal and apical poles. In humans, VENs have been described in the entorhinal cortex, the hippocampal formation, the anterior cingulate cortex, the rostral portion of the insula and the dorsomedial Brodmann's area 9 (BA9). These cortical regions have been associated with cognitive functions such as social interactions, intuition and emotional processing. Previous studies that searched for the presence of these cells in the lateral frontal poles yielded negative results. The presence of VENs in other cortical areas on the medial surface of the human prefrontal cortex which share both a common functional network and similar laminar organization, led us to examine its presence in the medial portion of the frontal pole. In the present study, we used tissue samples from five postmortem subjects taken from the polar portion of BA10, on the medial surface ...

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CORTEZA PREFRONTAL HUMANA: ÁREAS 10m, 11o Y 46d CITOARQUITECTURA E IMPLICACIONES FUNCIONALES

CORTEZA PREFRONTAL HUMANA: ÁREAS 10m, 11o Y 46d CITOARQUITECTURA E IMPLICACIONES FUNCIONALES Osca... more

Depresion postisquemia cerebral: una aproximacion fisiopatologica y clinica

Rev Colomb Psiquiatr, Dec 1, 2000

Resumo: La depresión y otras manifestaciones emocionales pueden ser consecuencia de lesiones isqu... more

Down-regulation of Bcl-2 in rat substantia nigra after focal cerebral ischemia

Neuroreport, Jul 1, 2004

After occlusion of the middle cerebral artery in rats, a robust neuronal loss occurs in the ipsil... more After occlusion of the middle cerebral artery in rats, a robust neuronal loss occurs in the ipsilateral substantia nigra reticulata. In this study we have assessed whether degeneration of the substantia nigra is accompanied by changes in the expression of the anti-apoptotic protein Bcl-2. Neuronal loss was assessed by neuronal nuclei (NeuN) immunoreactivity. A significant decrease of Bcl-2 expression was observed in the substantia nigra 12, 24 and 72 h after middle cerebral artery occlusion. These results suggest that the secondary neuronal loss in the substantia nigra could be related with the modification of proteins regulating programmed cell death. Exo-focal cell death may explain the appearance of neuropsychiatric symptoms that are not correlated with the primary site of lesion.