Papers by Flavia Mattioli
The European health psychologist, 2017
Background: Despite cognitive deficits frequently represent the first clinical manifestations of ... more Background: Despite cognitive deficits frequently represent the first clinical manifestations of Progressive Multifocal Leukoencephalopathy (PML), an uncommon opportunistic infection occurring in patients with multiple sclerosis (MS) treated with natalizumab (NTZ), the importance of cognitive neuropsychology in PML diagnosis is still under-appreciated. The aim of the current study is to investigate the cognitive deficit at PML diagnosis in the Italian PML cohort. Methods: All the Italian patients manifesting PML up to December 2016 (n=46) were included. The clinical data, lesion load, and longitudinal clinical course were compared between patients with (n = 19) and without (n = 21) cognitive deficit upon PML suspicion (the remaining six patients were asymptomatic). Findings: Within patients with cognitive onset, 41.10% were presenting with language and/or reading difficulties; 26.31% with memory difficulties; 21.05% with apraxia; 10.5% with disorientation; 10.5% with neglect; 10.5% ...
Multiple Sclerosis and Related Disorders, 2012
Neurology, 2012
ABSTRACT http://www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/P04.112
Health and Social Care Delivery Research
Background People with language problems following stroke (aphasia) benefit from speech and langu... more Background People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting Participant data were collected in research and clinical settings. Interventions The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data so...
Aphasiology, 2019
Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Grou... more Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as i...
Aphasiology, 2018
Background: Speech and language therapy (SLT) interventions for people with aphasia are complex –... more Background: Speech and language therapy (SLT) interventions for people with aphasia are complex – for example, interventions vary by delivery model (face-to-face, tele-rehabilitation), dynamic (gro...
Neurological Sciences, 2014
Aphasiology, 2018
Background: People with aphasia present with different of demographic, language, stroke, and impa... more Background: People with aphasia present with different of demographic, language, stroke, and impairment profiles. A Cochrane review found that two-thirds of included trials had comparison data on p...
Archives of Neuroscience, 2016
Journal of Applied Entomology, 2008
Experimental Brain Research, 2022
Temporal Binding Window (TBW) represents a reliable index of efficient multisensory integration p... more Temporal Binding Window (TBW) represents a reliable index of efficient multisensory integration process, which allows individuals to infer which sensory inputs from different modalities pertain to the same event. TBW alterations have been reported in some neurological and neuropsychiatric disorders and seem to negatively affects cognition and behavior. So far, it is still unknown whether deficits of multisensory integration, as indexed by an abnormal TBW, are present even in Multiple Sclerosis. We addressed this issue by testing 25 participants affected by relapsing–remitting Multiple Sclerosis (RRMS) and 30 age-matched healthy controls. Participants completed a simultaneity judgment task (SJ2) to assess the audio-visual TBW; two unimodal SJ2 versions were used as control tasks. Individuals with RRMS showed an enlarged audio-visual TBW (width range = from − 166 ms to + 198 ms), as compared to healthy controls (width range = − 177/ + 66 ms), thus showing an increased tendency to inte...
Journal of the Neurological Sciences, 2022
The exact incidence of neurological and cognitive sequelae of COVID-19 in the long term is yet un... more The exact incidence of neurological and cognitive sequelae of COVID-19 in the long term is yet unknown. The aim of this research is to investigate the type of neurological and cognitive impairment in COVID-19 cases of different severity. Two hundred fifteen patients, who had developed COVID-19, were examined 4 months after the diagnosis by means of neurological exam and extensive cognitive evaluation, investigating general cognition, memory, verbal fluency, visuospatial abilities and executive functions. Fifty-two of them were treated in intensive care unit (ICU patients), whereas 163 were not hospitalized (non-ICU patients). Neurological deficits were found in 2/163 (1.2%) of non-ICU and in 7/52 (13.5%) of the ICU cases, all involving the peripheral nervous system. ICU patients performed significantly worse in all the neuropsychological tests and showed a worse age- and education-corrected cognitive impairment: Cognitive Impairment Index (CII) was higher in ICU than in non-ICU patients (median ICU 3 vs 2, p = .001). CII significantly correlated with age in both groups, was unrelated to length of follow- up, diabetes and hypertension and - only for ICU patients- to PaO2/FiO2 at ICU admission. Obtained results support the greater susceptibility of COVID-19 patients, treated in ICU, to develop neurological deficits and cognitive impairment at a four-month follow up, as compared to cases with mild/moderate symptoms.
Stroke, 2021
Background and Purpose: The factors associated with recovery of language domains after stroke rem... more Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative varia...
International Journal of Stroke, 2016
Previous studies reported that Multiple Sclerosis (MS) patients treated with natalizumab for one ... more Previous studies reported that Multiple Sclerosis (MS) patients treated with natalizumab for one or two years exhibit a significant reduction in relapse rate and in cognitive impairment, but the long term effects on cognitive performance are unknown. This study aimed to evalu-ate the effects of natalizumab on cognitive impairment in a cohort of 24 consecutive patients with relapsing remitting MS treated for 3 years. The neuropsychological tests, as well as relapse number and EDSS, were assessed at baseline and yearly for three years. The impact on cortical atrophy was also considered in a subgroup of them, and are thus to be considered as preliminary. Results showed a significant reduction in the number of impaired neuropsychological tests after three years, a significant decrease in annualized relapse rate at each time points compared to baseline and a stable EDSS. In the neuropsychological assessment, a significant improvement in memory, attention and executive function test score...
effect of age and cerebral lesion
Journal of Neurology Research Reviews & Reports, 2021
Purpose: Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique wit... more Purpose: Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with the potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of deep TMS (dTMS) on a group of 10 patients diagnosed with amnesic MCI. Methods: We compared the effects of TMS COG treatment (dTMS delivered with H7 helmet for ten daily sessions together with cognitive training of memory and attention), with those of COG treatment (cognitive training alone) of the same duration. Results: Neuropsychological evaluation at baseline, after TMS COG treatment, after COG treatment and at six months follow up, compared with ANOVA, revealed a significant group-by-time interaction (𝑝 = 0.05), favoring the TMS COG treatment for memory tests. The improvement was kept after six months. Other neuropsychological tests were not significantly affected by treatm...
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Papers by Flavia Mattioli