Context Researchers investigating collision and contact sport participation during high school ha... more Context Researchers investigating collision and contact sport participation during high school have found mixed results. Understanding the association between current contact and collision sport participation and quality-of-life outcomes can enhance our knowledge about the risks and benefits of sport participation. Objective To examine quality-of-life outcomes among high school athletes who reported participation in collision and contact sports in the year preceding assessment compared with no- or limited-contact sport athletes. Design Cross-sectional study. Setting Preparticipation physical examination. Patients or Other Participants High school athletes 13 to 18 years of age. Main Outcome Measure(s) We obtained sport participation and Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric-25 outcomes, which assess self-reported, quality-of-life domains in the preceding 7 days (ie, state assessment). Our grouping variable was collision and contact versus no- or...
International Journal of Environmental Research and Public Health, 2021
Concussion management has evolved to de-emphasize rest in favor of early introduction of post-inj... more Concussion management has evolved to de-emphasize rest in favor of early introduction of post-injury physical activity. However, the optimal quantity, frequency and intensity of physical activity are unclear. Our objective was to examine the association between objective physical activity metrics and clinical recovery after concussion. We prospectively enrolled a cohort of 32 youth athletes with concussion, evaluated within 14 days of injury and after return-to-play (RTP) clearance. For two weeks after enrollment, we quantified steps/day and exercise frequency, duration, and intensity via wrist-worn actigraphy. We grouped participants by RTP clearance timing (<28 days vs. ≥28 days). Seventeen (53%) participants required ≥28 days post-concussion for RTP clearance. Groups were similar in age (14.9 ± 1.9 vs. 15.4 ± 1.5 years; p = 0.38), proportion of females (47% vs. 40%; p = 0.69), and concussion history (59% vs. 47%; p = 0.49). During the study period, the RTP ≥ 28 days group took...
EMPLOYMENT HARVARD UNIVERSITY, Department of East Asian Languages and Civilizations, Professor of... more EMPLOYMENT HARVARD UNIVERSITY, Department of East Asian Languages and Civilizations, Professor of Japanese History, 2010PRINCETON UNIVERSITY, Departments of East Asian Studies and History, Assistant Professor, 199399; Associate Professor, 1999-2004; Professor, 2004-10; Nissan Professor in Japanese Studies, 2009-10 Chair, Department of East Asian Studies, 2005-10; Acting Director, Program in East Asian Studies, 2001-02; Director of Graduate Studies, Department of East Asian Studies, 1996-97, 1998-2002 UNIVERSITY OF TEXAS AT AUSTIN, Department of History, Assistant Professor, 1989-92
Project financing is entering a new phase with the forthcoming petroleum developments in difficul... more Project financing is entering a new phase with the forthcoming petroleum developments in difficult areas such as Papua New Guinea.Added to the usual project financing risks, such as oil price, reserves and completion considerations, are new risks associated with the country. These are collectively termed 'political risk', and encompass expropriation, wars and currency controls.Four ways of mitigating political risk are individual banks increasing country limits, developer self- insurance, political risk insurance and the use of export credit finance. None of the above is a single solution, but all can be used in solving the problems associated with political risk.
Abstract Interprofessional education is becoming more popular in higher education and service-lea... more Abstract Interprofessional education is becoming more popular in higher education and service-learning has been a successful method to facilitate experiences that foster teamwork between professions. This report shares the results from an interprofessional service-learning project (ISLP) targeting students across eight disciplines (physician assistant, medicine, pharmacy, dietetic internship, physical therapy, master in health administration, nursing and biomedical science). The project used an existing resource, the South Carolina Area Health Education Consortium (SC-AHEC), to coordinate student learning across multiple regions and an established health promotion program curriculum for student outreach content. Participating students (n = 149) were evaluated to determine how the activity affected student appreciation and knowledge of their own and other professions, their interaction with other professional students, and student teamwork skills. Students found the most value in learning with students from other professions as part of the activity with lesser value placed on students increasing their knowledge about their profession&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s role in interprofessional work.
Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes, including in... more Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes, including inherited genetic defects, with significant proteinuria being the predominant clinical finding at presentation. Mutations in COL4A3 and COL4A4 are known to cause Alport syndrome (AS), thin basement membrane nephropathy, and to result in pathognomonic glomerular basement membrane (GBM) findings. Secondary FSGS is known to develop in classic AS at later stages of the disease. Here, we present seven families with rare or novel variants in COL4A3 or COL4A4 (six with single and one with two heterozygous variants) from a cohort of 70 families with a diagnosis of hereditary FSGS. The predominant clinical finding at diagnosis was proteinuria associated with hematuria. In all seven families, there were individuals with nephrotic-range proteinuria with histologic features of FSGS by light microscopy. In one family, electron microscopy showed thin GBM, but four other families had variable findings in...
Physicians. It has been published monthly since 1935. Copyright CHEST is the official journal of ... more Physicians. It has been published monthly since 1935. Copyright CHEST is the official journal of the American College of Chest ... 1996 BY THE AMERICAN COLLEGE OF CHEST PHYSICIANS at Google Indexer on October 21, 2009 chestjournal.chestpubs.org Downloaded from
The occurrence of focal segmental glomerulosclerosis (FSGS) in a familial pattern has been rarely... more The occurrence of focal segmental glomerulosclerosis (FSGS) in a familial pattern has been rarely reported previously. Over the last 10 years we have treated 31 patients among eight families with familial FSGS. The diagnosis was confirmed by renal biopsy in 18 cases, and each ...
Christine L. Lau, MD, Scott M. Palmer, MD, Katherine E. Posther, BA, David N. Howell, MD, PhD, Na... more Christine L. Lau, MD, Scott M. Palmer, MD, Katherine E. Posther, BA, David N. Howell, MD, PhD, Nancy L. Reinsmoen, PhD, H. Todd Massey, MD, Victor F. Tapson, MD, James J. Jaggers, MD, Thomas A. D'Amico, MD, and R. Duane Davis, Jr, MD
Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflamm... more Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflammatory responses independent of adaptive immunity, it remains unstudied in the context of transplant rejection. To investigate the role of innate immunity in the development of allograft ...
Background. Acute humoral rejection (AHR) has been associated with enhanced graft loss. Our study... more Background. Acute humoral rejection (AHR) has been associated with enhanced graft loss. Our study compared the renal allograft survival of patients with AHR treated with plasmapheresis (PP) and intrave- nous immunoglobulin (IVIG) with allograft survival in patients with acute ...
Abstract: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology,... more Abstract: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on ...
Abstract. Regulation of HLA class I and class II antigen expression was studied in hybrids of hum... more Abstract. Regulation of HLA class I and class II antigen expression was studied in hybrids of human T and B lymphoblastoid cell lines (LCL). The T-LCL CEMR.3 expresses no HLA class II antigens. It expresses little total HLA class I antigen and no HLA-B antigens. The B-LCL ...
Context Researchers investigating collision and contact sport participation during high school ha... more Context Researchers investigating collision and contact sport participation during high school have found mixed results. Understanding the association between current contact and collision sport participation and quality-of-life outcomes can enhance our knowledge about the risks and benefits of sport participation. Objective To examine quality-of-life outcomes among high school athletes who reported participation in collision and contact sports in the year preceding assessment compared with no- or limited-contact sport athletes. Design Cross-sectional study. Setting Preparticipation physical examination. Patients or Other Participants High school athletes 13 to 18 years of age. Main Outcome Measure(s) We obtained sport participation and Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric-25 outcomes, which assess self-reported, quality-of-life domains in the preceding 7 days (ie, state assessment). Our grouping variable was collision and contact versus no- or...
International Journal of Environmental Research and Public Health, 2021
Concussion management has evolved to de-emphasize rest in favor of early introduction of post-inj... more Concussion management has evolved to de-emphasize rest in favor of early introduction of post-injury physical activity. However, the optimal quantity, frequency and intensity of physical activity are unclear. Our objective was to examine the association between objective physical activity metrics and clinical recovery after concussion. We prospectively enrolled a cohort of 32 youth athletes with concussion, evaluated within 14 days of injury and after return-to-play (RTP) clearance. For two weeks after enrollment, we quantified steps/day and exercise frequency, duration, and intensity via wrist-worn actigraphy. We grouped participants by RTP clearance timing (<28 days vs. ≥28 days). Seventeen (53%) participants required ≥28 days post-concussion for RTP clearance. Groups were similar in age (14.9 ± 1.9 vs. 15.4 ± 1.5 years; p = 0.38), proportion of females (47% vs. 40%; p = 0.69), and concussion history (59% vs. 47%; p = 0.49). During the study period, the RTP ≥ 28 days group took...
EMPLOYMENT HARVARD UNIVERSITY, Department of East Asian Languages and Civilizations, Professor of... more EMPLOYMENT HARVARD UNIVERSITY, Department of East Asian Languages and Civilizations, Professor of Japanese History, 2010PRINCETON UNIVERSITY, Departments of East Asian Studies and History, Assistant Professor, 199399; Associate Professor, 1999-2004; Professor, 2004-10; Nissan Professor in Japanese Studies, 2009-10 Chair, Department of East Asian Studies, 2005-10; Acting Director, Program in East Asian Studies, 2001-02; Director of Graduate Studies, Department of East Asian Studies, 1996-97, 1998-2002 UNIVERSITY OF TEXAS AT AUSTIN, Department of History, Assistant Professor, 1989-92
Project financing is entering a new phase with the forthcoming petroleum developments in difficul... more Project financing is entering a new phase with the forthcoming petroleum developments in difficult areas such as Papua New Guinea.Added to the usual project financing risks, such as oil price, reserves and completion considerations, are new risks associated with the country. These are collectively termed 'political risk', and encompass expropriation, wars and currency controls.Four ways of mitigating political risk are individual banks increasing country limits, developer self- insurance, political risk insurance and the use of export credit finance. None of the above is a single solution, but all can be used in solving the problems associated with political risk.
Abstract Interprofessional education is becoming more popular in higher education and service-lea... more Abstract Interprofessional education is becoming more popular in higher education and service-learning has been a successful method to facilitate experiences that foster teamwork between professions. This report shares the results from an interprofessional service-learning project (ISLP) targeting students across eight disciplines (physician assistant, medicine, pharmacy, dietetic internship, physical therapy, master in health administration, nursing and biomedical science). The project used an existing resource, the South Carolina Area Health Education Consortium (SC-AHEC), to coordinate student learning across multiple regions and an established health promotion program curriculum for student outreach content. Participating students (n = 149) were evaluated to determine how the activity affected student appreciation and knowledge of their own and other professions, their interaction with other professional students, and student teamwork skills. Students found the most value in learning with students from other professions as part of the activity with lesser value placed on students increasing their knowledge about their profession&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s role in interprofessional work.
Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes, including in... more Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes, including inherited genetic defects, with significant proteinuria being the predominant clinical finding at presentation. Mutations in COL4A3 and COL4A4 are known to cause Alport syndrome (AS), thin basement membrane nephropathy, and to result in pathognomonic glomerular basement membrane (GBM) findings. Secondary FSGS is known to develop in classic AS at later stages of the disease. Here, we present seven families with rare or novel variants in COL4A3 or COL4A4 (six with single and one with two heterozygous variants) from a cohort of 70 families with a diagnosis of hereditary FSGS. The predominant clinical finding at diagnosis was proteinuria associated with hematuria. In all seven families, there were individuals with nephrotic-range proteinuria with histologic features of FSGS by light microscopy. In one family, electron microscopy showed thin GBM, but four other families had variable findings in...
Physicians. It has been published monthly since 1935. Copyright CHEST is the official journal of ... more Physicians. It has been published monthly since 1935. Copyright CHEST is the official journal of the American College of Chest ... 1996 BY THE AMERICAN COLLEGE OF CHEST PHYSICIANS at Google Indexer on October 21, 2009 chestjournal.chestpubs.org Downloaded from
The occurrence of focal segmental glomerulosclerosis (FSGS) in a familial pattern has been rarely... more The occurrence of focal segmental glomerulosclerosis (FSGS) in a familial pattern has been rarely reported previously. Over the last 10 years we have treated 31 patients among eight families with familial FSGS. The diagnosis was confirmed by renal biopsy in 18 cases, and each ...
Christine L. Lau, MD, Scott M. Palmer, MD, Katherine E. Posther, BA, David N. Howell, MD, PhD, Na... more Christine L. Lau, MD, Scott M. Palmer, MD, Katherine E. Posther, BA, David N. Howell, MD, PhD, Nancy L. Reinsmoen, PhD, H. Todd Massey, MD, Victor F. Tapson, MD, James J. Jaggers, MD, Thomas A. D'Amico, MD, and R. Duane Davis, Jr, MD
Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflamm... more Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflammatory responses independent of adaptive immunity, it remains unstudied in the context of transplant rejection. To investigate the role of innate immunity in the development of allograft ...
Background. Acute humoral rejection (AHR) has been associated with enhanced graft loss. Our study... more Background. Acute humoral rejection (AHR) has been associated with enhanced graft loss. Our study compared the renal allograft survival of patients with AHR treated with plasmapheresis (PP) and intrave- nous immunoglobulin (IVIG) with allograft survival in patients with acute ...
Abstract: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology,... more Abstract: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on ...
Abstract. Regulation of HLA class I and class II antigen expression was studied in hybrids of hum... more Abstract. Regulation of HLA class I and class II antigen expression was studied in hybrids of human T and B lymphoblastoid cell lines (LCL). The T-LCL CEMR.3 expresses no HLA class II antigens. It expresses little total HLA class I antigen and no HLA-B antigens. The B-LCL ...
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