International Journal for Research in Applied Science and Engineering Technology
Constructed spaces have the ability to influence the lives of people living in those spaces for g... more Constructed spaces have the ability to influence the lives of people living in those spaces for good or bad. They have the potential to influence the user's experience. This can be done by choreographing each area in a building in order to give a person different perceptions when going through those areas. We experience any visual frame as we pass through a built space and view it in relation to the neighboring frame. At the same time, we do not simply see them when moving via a space, but even our senses are also engaged in the space perception process. They are driving our front ward motion unintentionally and our unintentional pauses. As we pass through a construction, we see the various components of the building unfold. One needs to decipher the various layers that articulate these spaces in order to address the kinesthetic factor. The order of spaces not only controls the direction of motion and the pattern of motion, but also indicates that an individual pauses or continues. Many experiences are felt because of the sequential emergence of various spaces when going through Indian traditional architecture. These observations are not accidental but are the result of conscious design decisions. But the concept of kinesthetics is ignored as an incidental phenomenon if we focus at contemporary architecture. Architects have some goals that they tackle any project with. Among them, the user experience is typically given the least importance, even though it is the most vital issue. The opportunity for buildings built with sound kinesthetics is to construct a human environment that is conducive to its inhabitants. This research is an attempt to find out the variables by paying close attention to the kinesthetics of a space from which the experience of the users can be improved.
Indian Journal of Vascular and Endovascular Surgery
Endovascular aortic repair is becoming the standard of care for abdominal aortic aneurysm. Despit... more Endovascular aortic repair is becoming the standard of care for abdominal aortic aneurysm. Despite aorta being a high flow system, there is still a definite risk of endograft occlusion. Management of occluded aortic endograft is highly controversial. Successful endovascular relining in aortic endograft occlusion is a technically demanding and forthcoming secondary intervention, not been studied extensively. We are reporting a case of aortic endograft thrombosis in a morbidly obese, 64-year-old gentleman with multiple comorbidities presenting with lifestyle-limiting claudication. The patient had a history of abdominal aortic aneurysm repair with aorto-uni-iliac device and femorofemoral bypass. The patient was managed by relining of aortic endograft with graft thrombectomy and snorkeling of the left renal artery. Postoperative course was uneventful. After 1 year of follow-up, the patient is free of symptoms with patent endograft. More empirical evidence is yet required to make the standard guidelines for the management of aortic endograft occlusion.
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2015
Acquired immunodeficiency syndrome (AIDS) is a life threatening disease of the human immune syste... more Acquired immunodeficiency syndrome (AIDS) is a life threatening disease of the human immune system caused by human immunodeficiency virus (HIV). Effective inhibition of reverse transcriptase activity is a prominent, clinically viable approach for the treatment of AIDS. Few non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been approved by the United States Food and Drug Administration (US FDA) as drugs for AIDS. In order to enhance therapeutic options against AIDS we examined novel herbal compounds of 4-thiazolidinone and its derivatives that are known to have remarkable antiviral potency. Our molecular docking and simulation experiments have identified one such herbal molecule known as (5E)-3-(2-aminoethyl)-5-benzylidene-1, 3-thiazolidine-2,4-dione that may bind HIV-1RT with high affinity to cause noncompetitive inhibition. Results are also compared with other US FDA approved drugs. Long de novo simulations and docking study suggest that the ligand (5E)-3-(2-aminoethyl)-5-benzylidene-1, 3-thiazolidine-2,4-dione (CID: 1656714) has strong binding interactions with Asp113, Asp110, Asp185 and Asp186 amino acids, all of which belong to one or the other catalytic pockets of HIV-1RT. It is expected that these interactions could be critical in the inhibitory activity of the HIV-1RT. Therefore, this study provides an evidence for consideration of (5E)-3-(2-aminoethyl)-5-benzylidene-1, 3-thiazolidine-2,4-dione as a valuable natural molecule in the treatment and prevention of HIV- associated disorders.
This is a report of a 47-year-old man presenting to the Emergency Department complaining of bilat... more This is a report of a 47-year-old man presenting to the Emergency Department complaining of bilateral shoulder pain after developing pain in the right shoulder about 1(1/2)-2 weeks prior after heavy lifting while at work. Clinical suspicion of Gonococcal arthritis was confirmed on the basis of laboratory studies. Although Gonococcal arthritis is occasionally associated with uniarticular arthritis, this patient presented with bilateral joint involvement.
In the present study, depending upon the availability and cheaper cost, different carbon source w... more In the present study, depending upon the availability and cheaper cost, different carbon source were tested for the production of PHAs (Polyhydroxyalkonoates) by soil bacterium Pseudomonas aeruginosa and it was found that sugar refinery waste (cane ...
Communications in Soil Science and Plant Analysis, 2014
ABSTRACT Vermicompost (VC) produced from distillation waste of geranium (Pelargonium graveolens),... more ABSTRACT Vermicompost (VC) produced from distillation waste of geranium (Pelargonium graveolens), farmyard manure (FYM) produced from animal excreta mixed with pine needle (Pinus sp.), and biofertilzer (Azotobacter) were utilized for this experiment. The plant growth attributes, biomass, and oil yield of geranium were significantly increased with integrated nutrient supply, and maximum increase was found in T8 treatments (N100P60 K60 + 5t VC). Soil organic carbon (Corg) significantly increased by 4.2% to 81.8% in T4 and T8 treatments, respectively, over the control. Data obtained on total nitrogen (Nt) and available N, phosphorus (P), and potassium (K) clearly showed that the integrated nutrient supply considerably improved the soil health and sustainability. The soil respiration and microbial biomass C (Cmic) and N (Nmic) were increased by the manures according to the application rate. The Cmic accounted for 1.8 to 2.7% of the soil Corg content and microbial N accounted for 3.9 to 5.8 % of Nt under different treatment combinations.
Uranium, the heaviest radioactive toxic element is found in almost all types of soils, rocks, san... more Uranium, the heaviest radioactive toxic element is found in almost all types of soils, rocks, sands and water. Uranium is the ultimate source of 226 Ra and 222 Rn. Radon isotopes are decay products of radium in the uranium decay series. As an inert gas radon can diffuse through ...
Proinflammatory cytokines, especially tumor necrosis factor α (TNFα), is a pleiotropic mediator o... more Proinflammatory cytokines, especially tumor necrosis factor α (TNFα), is a pleiotropic mediator of a diverse array of physiologic and neurologic functions and is upregulated during various inflammatory and neurodegenerative diseases. A common survival ...
Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycl... more Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycles attached to the 'piperazinyl-phenyl-oxazolidinone' core of eperezolid. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible gram-positive organisms, along with the identification of ranbezolid (RBx 7644) as a clinical candidate.
International Journal for Research in Applied Science and Engineering Technology
Constructed spaces have the ability to influence the lives of people living in those spaces for g... more Constructed spaces have the ability to influence the lives of people living in those spaces for good or bad. They have the potential to influence the user's experience. This can be done by choreographing each area in a building in order to give a person different perceptions when going through those areas. We experience any visual frame as we pass through a built space and view it in relation to the neighboring frame. At the same time, we do not simply see them when moving via a space, but even our senses are also engaged in the space perception process. They are driving our front ward motion unintentionally and our unintentional pauses. As we pass through a construction, we see the various components of the building unfold. One needs to decipher the various layers that articulate these spaces in order to address the kinesthetic factor. The order of spaces not only controls the direction of motion and the pattern of motion, but also indicates that an individual pauses or continues. Many experiences are felt because of the sequential emergence of various spaces when going through Indian traditional architecture. These observations are not accidental but are the result of conscious design decisions. But the concept of kinesthetics is ignored as an incidental phenomenon if we focus at contemporary architecture. Architects have some goals that they tackle any project with. Among them, the user experience is typically given the least importance, even though it is the most vital issue. The opportunity for buildings built with sound kinesthetics is to construct a human environment that is conducive to its inhabitants. This research is an attempt to find out the variables by paying close attention to the kinesthetics of a space from which the experience of the users can be improved.
Indian Journal of Vascular and Endovascular Surgery
Endovascular aortic repair is becoming the standard of care for abdominal aortic aneurysm. Despit... more Endovascular aortic repair is becoming the standard of care for abdominal aortic aneurysm. Despite aorta being a high flow system, there is still a definite risk of endograft occlusion. Management of occluded aortic endograft is highly controversial. Successful endovascular relining in aortic endograft occlusion is a technically demanding and forthcoming secondary intervention, not been studied extensively. We are reporting a case of aortic endograft thrombosis in a morbidly obese, 64-year-old gentleman with multiple comorbidities presenting with lifestyle-limiting claudication. The patient had a history of abdominal aortic aneurysm repair with aorto-uni-iliac device and femorofemoral bypass. The patient was managed by relining of aortic endograft with graft thrombectomy and snorkeling of the left renal artery. Postoperative course was uneventful. After 1 year of follow-up, the patient is free of symptoms with patent endograft. More empirical evidence is yet required to make the standard guidelines for the management of aortic endograft occlusion.
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2015
Acquired immunodeficiency syndrome (AIDS) is a life threatening disease of the human immune syste... more Acquired immunodeficiency syndrome (AIDS) is a life threatening disease of the human immune system caused by human immunodeficiency virus (HIV). Effective inhibition of reverse transcriptase activity is a prominent, clinically viable approach for the treatment of AIDS. Few non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been approved by the United States Food and Drug Administration (US FDA) as drugs for AIDS. In order to enhance therapeutic options against AIDS we examined novel herbal compounds of 4-thiazolidinone and its derivatives that are known to have remarkable antiviral potency. Our molecular docking and simulation experiments have identified one such herbal molecule known as (5E)-3-(2-aminoethyl)-5-benzylidene-1, 3-thiazolidine-2,4-dione that may bind HIV-1RT with high affinity to cause noncompetitive inhibition. Results are also compared with other US FDA approved drugs. Long de novo simulations and docking study suggest that the ligand (5E)-3-(2-aminoethyl)-5-benzylidene-1, 3-thiazolidine-2,4-dione (CID: 1656714) has strong binding interactions with Asp113, Asp110, Asp185 and Asp186 amino acids, all of which belong to one or the other catalytic pockets of HIV-1RT. It is expected that these interactions could be critical in the inhibitory activity of the HIV-1RT. Therefore, this study provides an evidence for consideration of (5E)-3-(2-aminoethyl)-5-benzylidene-1, 3-thiazolidine-2,4-dione as a valuable natural molecule in the treatment and prevention of HIV- associated disorders.
This is a report of a 47-year-old man presenting to the Emergency Department complaining of bilat... more This is a report of a 47-year-old man presenting to the Emergency Department complaining of bilateral shoulder pain after developing pain in the right shoulder about 1(1/2)-2 weeks prior after heavy lifting while at work. Clinical suspicion of Gonococcal arthritis was confirmed on the basis of laboratory studies. Although Gonococcal arthritis is occasionally associated with uniarticular arthritis, this patient presented with bilateral joint involvement.
In the present study, depending upon the availability and cheaper cost, different carbon source w... more In the present study, depending upon the availability and cheaper cost, different carbon source were tested for the production of PHAs (Polyhydroxyalkonoates) by soil bacterium Pseudomonas aeruginosa and it was found that sugar refinery waste (cane ...
Communications in Soil Science and Plant Analysis, 2014
ABSTRACT Vermicompost (VC) produced from distillation waste of geranium (Pelargonium graveolens),... more ABSTRACT Vermicompost (VC) produced from distillation waste of geranium (Pelargonium graveolens), farmyard manure (FYM) produced from animal excreta mixed with pine needle (Pinus sp.), and biofertilzer (Azotobacter) were utilized for this experiment. The plant growth attributes, biomass, and oil yield of geranium were significantly increased with integrated nutrient supply, and maximum increase was found in T8 treatments (N100P60 K60 + 5t VC). Soil organic carbon (Corg) significantly increased by 4.2% to 81.8% in T4 and T8 treatments, respectively, over the control. Data obtained on total nitrogen (Nt) and available N, phosphorus (P), and potassium (K) clearly showed that the integrated nutrient supply considerably improved the soil health and sustainability. The soil respiration and microbial biomass C (Cmic) and N (Nmic) were increased by the manures according to the application rate. The Cmic accounted for 1.8 to 2.7% of the soil Corg content and microbial N accounted for 3.9 to 5.8 % of Nt under different treatment combinations.
Uranium, the heaviest radioactive toxic element is found in almost all types of soils, rocks, san... more Uranium, the heaviest radioactive toxic element is found in almost all types of soils, rocks, sands and water. Uranium is the ultimate source of 226 Ra and 222 Rn. Radon isotopes are decay products of radium in the uranium decay series. As an inert gas radon can diffuse through ...
Proinflammatory cytokines, especially tumor necrosis factor α (TNFα), is a pleiotropic mediator o... more Proinflammatory cytokines, especially tumor necrosis factor α (TNFα), is a pleiotropic mediator of a diverse array of physiologic and neurologic functions and is upregulated during various inflammatory and neurodegenerative diseases. A common survival ...
Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycl... more Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycles attached to the 'piperazinyl-phenyl-oxazolidinone' core of eperezolid. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible gram-positive organisms, along with the identification of ranbezolid (RBx 7644) as a clinical candidate.
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Papers by Ajay Yadav