SigTuple

🔬 The Importance of Diagnosing Macrocytic Anemias and the Role of AI in Differentiation Continuing our series on intriguing medical cases diagnosed using SigTuple's AI100, today we explore the significance of identifying and diagnosing macrocytic anemias and the vital role of AI in differentiating between round and oval macrocytes. Understanding Macrocytosis: Macrocytosis refers to a condition where red blood cells (RBCs) are larger than normal, typically indicated by an elevated Mean Corpuscular Volume (MCV). While MCV values ranging from 80 to 100 femtoliters (fl) are considered normal, larger RBCs can indicate macrocytosis, a condition that may or may not be associated with anemia. Types of Macrocytic Anemia: Megaloblastic Anemia: Characterized by the presence of oval macrocytes, commonly caused by vitamin B12 or folic acid deficiency. Non-Megaloblastic Anemia: Identified by round macrocytes, with causes including alcoholism, liver disease, hypothyroidism, and more. Case Study: In a recent case, a patient with macrocytic anemia presented with round macrocytes. The AI100, powered by Shonit, accurately flagged and classified these round macrocytes, showcasing its advanced capabilities. This differentiation is crucial for the pathologist and clinician to manage the condition effectively. Laboratory Findings: Hemoglobin (Hb): 9.7 g/dl MCV: 102.7 fL The AI100 provides visual evidence and ICHS grading, enhancing the accuracy and efficiency of diagnosing macrocytic anemia. The Role of AI in Diagnosis: Identifying the cause of macrocytosis can be challenging, requiring a systematic approach that includes clinical history, physical examination, complete blood count (CBC), and peripheral smear examination. The AI100 supports pathologists by providing precise, visual-based evidence, ensuring accurate differentiation and interpretation of macrocytic anemia. Stay tuned for more insights as we continue to explore the impact of AI in medical diagnostics. #MacrocyticAnemia #AIinHealthcare #SigTuple Case courtesy: Dr. Arivarasan, Bose clinic - Madurai. Dr. Renu Ethirajan Pranat Bhadani Suman Gautam Tathagato Rai Dastidar

🌟 Taking Innovation to New Horizons! 🌟 We’re absolutely thrilled to announce that our CEO, Dr Tathagato Rai Dastidar, was spotlighted in an exclusive interview by TECHBLITZ! In this interview, Dr. Dastidar shares the incredible journey of SigTuple and how our groundbreaking SigTuple-AI100 is transforming the landscape of blood and urine sample testing. From automating processes traditionally dependent on human labor to enabling remote diagnostics in rural India, our innovation is making waves across the healthcare industry. FDA-approved and fueled by cutting-edge AI, the SigTuple-AI100 is not just a product—it’s a revolution in medical diagnostics. And as we set our sights on new horizons, including Japan and beyond, we’re filled with pride at the impact we’re making globally. Join us in celebrating this milestone and learn more about our mission to make world-class healthcare accessible to all! Original Japanese version https://lnkd.in/gQnXS7ys The Google English translation of the article https://lnkd.in/dZmgUtGj #AI #SigTuple #RemoteDiagnostics #GlobalImpact #Techblitz Pranat Bhadani Suman Gautam Dr. Renu Ethirajan

Some exciting news to share!! We are thrilled to announce that SigTuple has secured an investment of INR 33 crores ($4M) led by SIDBI Venture Capital Ltd, with participation from existing investors including Endiya Partners, and a few strategic leaders from the Healthcare sector. The team will use this new capital to drive geographical expansion, expand its product portfolio and support regulatory clearances. We welcome SIDBI Venture Capital Ltd on this journey to decentralise diagnostics and fully automate the microscopic review of diseased samples - Debraj Banerjee, Pradnya S. & Fenil Zaveri 🙏 Endiya Partners continues to be our pillar of strength - Dr. Ramesh Byrapaneni, Sateesh Andra 🙏 Tathagato Rai Dastidar Pranat Bhadani Apurv Manjrekar Kundan Kumar Dharmatej Bhat Seema Singh #OnwardsAndUpwards

What an exhilarating event it was! Going into ADLM, one of the largest global trade shows for laboratory medical devices, we were nervous indeed. AS76 has been years of hard work and sweat from the entire team, and this was the first time we were showcasing our product to the industry. Over the last week, we had a chance to engage with eminent pathologists, dominant medical device distributors and giant global OEM's, and to hear from these industry titans that "AS76 would now be the new benchmark for microscopic review of peripheral blood smears " was the most satisfying thing for us to hear. For the last 12 months, we have been our biggest critic - from robotics to optics to data science to engineering and product - every team has pushed themselves to the limit to ensure that we can redefine microscopy for the times to come - and it really showed in the feedback we received. The team is super charged to see the efforts bear fruit, but this is only the beginning - keep watching this space to see how we continue to disrupt the microscopic review of all biological slides! #OnwardsAndUpwards #AI #DigitalPathology #AutomateMicroscopy Tathagato Rai Dastidar Pranat Bhadani Apurv Manjrekar Kundan Kumar Dharmatej Bhat Seema Singh Suman Gautam Dr. Renu Ethirajan Manohar Daka P.S: Special mention to Dr. Ramesh Byrapaneni (Endiya Partners) for coming all the way to Chicago to support us. Thank you :) P.P.S: Next time onwards, we might need someone dedicated to just take pictures of guests coming to our booth!

🔬 Join Our Exclusive Webinar on Digital Pathology! 🔬 Episode 5: Digital Pathology and AI in India: The Scenario, Rush, and Way Forward 🗓 Date: August 3, 2024 🕖 Time: 6:00 PM - 7:00 PM (IST) 🌟 Guest Speaker: Dr. Kunal Sharma Associate Director and HOD (Centre of Excellence and Histopathology), Global Reference Laboratory, Agilus (formerly SRL) Diagnostics Are you passionate about the latest advancements in pathology and digital technology? Join us for an insightful webinar on "Digital Pathology and AI in India: The Scenario, Rush, and Way Forward" with renowned expert Dr. Kunal Sharma. Dr. Sharma is an Associate Director & HOD at Mumbai Reference Lab, Agilus Diagnostics, where he leads the Digital Pathology & AI initiatives. Trained in oncopathology at HCG Cancer Hospital, Bengaluru, he has extensive experience in advanced onco-diagnostics, including IHC and molecular assays. His contributions to the field have been recognized at numerous national and international conferences. He also has numerous publications in journals of high repute like Archives of Pathology, IJSO, American Journal of Hematology, Springer Nature etc. His study on double & triple hit lymphomas, one of the largest from India, was presented at the International Leukemia, Lymphoma & Myeloma Congress, New York. 🔗 Registration Link: https://lnkd.in/g_KsBeQq 👉 Don't miss this opportunity to gain valuable insights into the world of digital pathology. Reserve your spot today and be part of this informative discussion. Spread the word and tag a friend or colleague who might be interested! Let's advance the field of pathology together. 🌐 #DigitalPathology #Webinar #Healthcare Note: This webinar will be hosted on a secure platform. Registered participants will receive a confirmation email with the webinar access details. Dr. Renu Ethirajan Dr Sharitha Naganna Dr Pavithra Devi Dr Chaitra C Dr Gayathri Talapula

All set for the launch of AS76! Do drop by and witness the future of digital pathology. Booth #4606 #ADLM #AI #DigitalPathology #PBS Tathagato Rai Dastidar Pranat Bhadani Apurv Manjrekar Dr. Ramesh Byrapaneni

⏳ Only 3 Days to Go! ⏳ We're counting down the days to the ADLM event in Chicago! Don't miss the chance to explore our cutting-edge AI-driven medical device, AS76, at Booth #4606. Gear up to • Witness the revolutionary AS76 in action • Get exclusive insights from our team of experts • Learn how our innovations can transform medical diagnostics 📆 Schedule Your Visit: Secure your spot and ensure a personalized experience by scheduling a meeting with us using this link https://lnkd.in/gWPkwyxu We're excited to connect with you and share our vision for the future of healthcare. See you soon! #ADLM2024 #MedicalInnovation #SigTuple Tathagato Rai Dastidar Pranat Bhadani Suman Gautam Dr. Renu Ethirajan Apurv Manjrekar

🎉 Celebrating 9 Years of Excellence! 🎉 We mark a special milestone as we celebrate our 9th anniversary! Over the years, we've grown, innovated, and achieved incredible milestones, all thanks to our dedicated team, supportive clients, and valued partners. From were we are today in the industry, our journey has been filled with challenges, learnings, and triumphs. We couldn't have done it without the hard work and commitment of our amazing team, who continue to drive our success every day. As we look forward to the future, we are excited about the endless possibilities and the opportunities that lie ahead. Here's to many more years of growth, innovation, and success! Thank you for being a part of our journey. Together, we will continue to reach new heights! #Anniversary #CompanyMilestone #TeamSuccess #Growth #Innovation #Gratitude

🔬 An Interesting Case of AML with Monocytic Differentiation We are excited to kick off a series where we share intriguing medical cases diagnosed using the SigTuple AI100. Our first case highlights the powerful diagnostic capabilities of our technology. Case Overview: A 57-year-old male presented with a two-month history of fever. A peripheral smear was analyzed using the SigTuple AI100, revealing the presence of blasts along with 21% cells with monocytic differentiation composed of promonocytes, monoblasts, and monocytes. CBC Findings: • Hemoglobin (Hb): 9.4 g/dl • WBC count: 38.5 x 10^3 /uL • Platelet count: 127 x 10^3 /uL Flow Cytometry Results: 60% of the blasts gated were positive for CD13, CD33, cMPO, HLA-DR, CD11b, CD64, CD123 AND CD38. NEGATIVE FOR T-CELL MARKERS, cCD3, cCD79a, CD34, CD20, KAPPA/LAMBDA, CD56, AND CD16. Impression: Acute Myeloid Leukemia (AML) with monocytic differentiation. Discussion: Acute myelomonocytic leukemia (AMML) is a distinct subtype of AML characterized by the proliferation of both neutrophil and monocyte precursors. According to the 2022 WHO classification, AMML accounts for 5-10% of AML cases and is more common in older individuals, with a median age of 50 years and a male-to-female ratio of 1.4:1. Key Features of AMML: • Evidence of both granulocytic and monocytic differentiation • Blasts/blast equivalents (myeloblasts, monoblasts, promonocytes) must comprise at least 20% of blood or bone marrow cells • Granulocytic differentiation is present but cells of monocytic lineage must be at least 20% of cells Microscopic(histological) Description: • Myeloblasts: High N:C ratios, round nuclei, variably granular cytoplasm, occasional Auer rods • Monoblasts: Large cells with abundant, moderately to intensely basophilic cytoplasm. May have pseudopod formation, scattered fine azurophilic granules, and vacuoles. Often with round nuclei with lacy chromatin and one or more large nucleoli • Promonocytes: have more irregular nuclei, typically with delicate folds and abundant, less basophilic cytoplasm which is more obviously granulated with occasional large azurophilic granules and vacuoles. This case underscores the critical role of advanced diagnostic tools like the SigTuple AI100 in identifying complex medical conditions accurately and efficiently. Stay tuned for more interesting cases in our series! Case courtesy: Dr. Arivarasan, Bose clinic - Madurai. #Leukemia #SigTuple #AIinHealthcare Dr. Renu Ethirajan Pranat Bhadani Suman Gautam Tathagato Rai Dastidar

🚀 Exciting News! 🚀 We are thrilled to invite you to visit SigTuple at the upcoming Association for Diagnostics & Laboratory Medicine (ADLM) event at McCormick Place in Chicago from July 30th to August 1st! Join us at Booth #4606 to experience the launch of SigTuple's latest innovation AS76, a multi-specimen digital pathology platform. ⭐ Why Visit Our Booth? • Be the first to experience the groundbreaking AS76 • Engage with our expert team and get hands-on demonstrations • Discover how AS76 can revolutionize medical diagnostics 📅 Schedule Your Visit: To ensure you get the most out of your visit, schedule a one-on-one session with our team by clicking on this link. https://lnkd.in/ej3-CkFi We can’t wait to show you how SigTuple is pushing the boundaries of medical technology. See you in Chicago! #ADLM2024 #MedicalInnovation #SigTuple Tathagato Rai Dastidar Pranat Bhadani Suman Gautam Dr. Renu Ethirajan Apurv Manjrekar