In this paper, we introduce a new spatially resolved model to simulate first pass perfusion of compounds within the naive liver.

Mar 13, 2014 · In this paper, we introduce a new spatially resolved model to simulate first pass perfusion of compounds within the naive liver. The model is ...

Mar 13, 2014 · In this paper, we introduce a new spatially resolved model to simulate first pass perfusion of compounds within the naive liver.

The combined model allows a detailed simulation of hepatic distribution and metabolization to accurately describe spatio-temporal effects underlying first-pass ...

essentially 1D flow (advection) through vascular systems. □ 3D Darcy flow in sinusoidal subspace, both discretized using [1]. □ liver tissue represented as ...

Abstract: The liver is the central organ for detoxification of xenobiotics in the body. In pharmacokinetic modeling, hepatic metabolization capacity is ...

Mar 15, 2014 · In this paper, we introduce a new spatially resolved model to simulate first pass perfusion of compounds within the naive liver. The model is ...

Institute for Experimental Molecular Imaging. Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver. Schwen, Lars Ole; Krauss, Markus ...

The liver is the central organ for detoxification of xenobiotics in the body. In pharmacokinetic modeling, hepatic metabolization capacity is typically ...

Dec 7, 2013 · SPATIO-TEMPORAL SIMULATION OF FIRST PASS. DRUG PERFUSION IN THE MOUSE LIVER. Lars Ole Schwen joint work with: Markus Krauss (BTS Leverkusen ...