CONCLUSIONS The R306S mutation, gene mutant of PCSK9, could significantly lead to the decrease of LDL-R mature protein expression. Analysis results obtained ...
The abovementioned study suggests that, wild type PCSK9 can inhibit LDL-R protein expression and lower. LDL intake in liver, thus lower serum LDL clearance. It ...
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Inhibition of PCSK9 increases expression of LDLR, thereby reducing plasma levels of lipoproteins and the risk of cardiovascular disease. PCSK9 inhibition also ...
Missing: R306S | Show results with:R306S
... functional replacement of water occupying stable PCSK9 hydration sites. The R306S mutation could significantly lead to the decrease of LDL-R mature protein ...
PCSK9 induces lysosomal degradation of the low-density lipoprotein (LDL) receptor in the liver, which is responsible for clearing LDL-cholesterol (LDL-C) from ...
GOF variants in PCSK9 have been found proven to lead to FH through reducing LDLR protein expression in the liver and decreasing the clearance of circulating ...
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