The authors (4) propose that the activity of an intact extrusion complex can halt the activity of a neighboring extrusion complex that lacks an anchor. On the ...
Predictive model of 3D domain formation via CTCF-mediated extrusion. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14404-5. doi: 10.1073/pnas.1519849112 ...
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
Nov 24, 2015 · Predictive model of 3D domain formation via CTCF-mediated extrusion. / Yardimci, Galip Gürkan; Noble, William Stafford. In: Proceedings of the ...
Predictive model of 3D domain formation via CTCF-mediated extrusion · G. Yardımcı, William Stafford Noble · Published in Proceedings of the National… 13 November ...
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What are the domains of CTCF?
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We provide a formal method to quantify deletions based on their potential disruption of the three-dimensional genome structure, denoted as the TAD fusion score.
Aug 23, 2022 · We propose a novel deep learning model, called CLNN-loop, to predict chromatin loops in different cell lines and CTCF-binding sites (CBS) pair types.
Dec 3, 2015 · 7. Extrusion models explain CTCF site directionality in the formation of loops. An intriguing question arising from these observations is how ...
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Apr 19, 2023 · Several mechanisms have been suggested for how CTCF might prevent loop extrusion across TAD boundaries (reviewed previously), namely, as a ...
Aug 11, 2023 · Here we have developed a deep-learning model, DeepAnchor, to accurately characterize CTCF binding using high-resolution genomic/epigenomic features.