We empirically find that the patterns of mutually exclusivity ASTER finds using genomic and transcriptomic data provides a strong signal of synthetic lethality.
Apr 1, 2021 · We design a new technique based on statistical hypothesis testing, called ASTER, to identify SL pairs.
Mar 7, 2024 · Leveraging unified gene ex- pression data of both disease-free and cancerous samples, we design a new technique based on statistical hypothesis.
Apr 1, 2021 · Survival probability is predicted using Cox proportional hazard model while controlling for confounding factors such as cancer type, patient ...
We empirically find that the patterns of mutually exclusivity ASTER finds using genomic and transcriptomic data provides a strong signal of synthetic lethality.
A Synthetic Lethal (SL) interaction is a functional relationship between two genes or functional entities where the loss of either entity is viable but the ...
Missing: Relevant | Show results with:Relevant
The identification of clinically relevant synthetic lethality ... Aster: A method to predict clinically actionable synthetic lethal genetic interactions, 10.
People also ask
What is synthetic lethality genetic interaction?
How to prove synthetic lethality?
What is synthetic lethality in cancer?
What is synthetic lethality in yeast genetics?
Aug 30, 2024 · ASTER: a method to predict clinically actionable synthetic lethal interactions ... predict genetic interactions . PLoS Comput Biol. 2010. ;. 6.
Missing: Relevant | Show results with:Relevant
ASTER: A Method to Predict Clinically Actionable Synthetic Lethal Interactions ... method to predict synthetic lethality pairs of genes that combines a ...
These in silico methods can predict phenotypes and gene functions and are applicable to genomic synthetic lethality screens in yeast and analogous RNA ...
Missing: ASTER: Clinically