Gonadotropinen askapenerako hormona

GNRH1
Identifikatzaileak
Aliasak	GNRH1 (HUGO), GNRH, GRH, HH12, LHRH, LNRH, gonadotropin releasing hormone 1, Gonadotropin-Releasing Hormone
Kanpoko IDak	OMIM: 152760 MGI: 95789 HomoloGene: 641 GeneCards: GNRH1 OMA: GNRH1 - orthologs
Genetikoki lotutako gaixotasunak
	hypogonadotropic hypogonadism 12 with or without anosmia
Genearen kokapena (gizakia)
	Kromosoma: 8 (gizakia)
Amaiera	25.424.654 bp
Genearen kokapena (sagua)
	Kromosoma: 14 (sagua)
Amaiera	67.986.888 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	Nerbio tibial ; ; Barrabil; ; cerebellar hemisphere ; ; putamen ; ; ascending aorta ; ; Descending thoracic aorta ; ; mucosa of transverse colon ; ; right hemisphere of cerebellum ; ; popliteal artery ; ; Tibial arteries ;
	Adierazpen ohikoena
	primary oocyte ; ; hezur-muin; ; embryonic cell ; ; zigoto; ; secondary oocyte ; ; morula ; ; neural layer of retina ; ; granulozito; ; Timo; ; preoptic area ;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	hormone activity ; gonadotropin hormone-releasing hormone activity ; gonadotropin-releasing hormone receptor binding ;
Zelularen osagaia	axon terminus ; Soma ; Golgi-associated vesicle ; zelulaz kanpoko eremu ; neurosecretory vesicle ; Dendrita ; mitokondrio ; neuron projection ; cytoplasmic side of rough endoplasmic reticulum membrane ; extracellular space ;
Prozesu biologikoa	negative regulation of immature T cell proliferation ; response to prolactin ; negative regulation of neuron migration ; response to potassium ion ; response to organic cyclic compound ; response to testosterone ; estrous cycle ; female pregnancy ; cell-cell signaling ; response to steroid hormone ; giza zahartze ; response to peptide hormone ; negative regulation of apoptotic process ; male sex determination ; izaki zelulanitzen garapena ; response to prostaglandin E ; response to lipopolysaccharide ; response to corticosteroid ; gene-erregulazio ; ovulation cycle ; response to ethanol ; regulation of ovarian follicle development ; seinale transdukzio ; negative regulation of cell population proliferation ; regulation of signaling receptor activity ; G proteina errezeptore akoplatuaren komunikazio bidea ; ugalketa ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	2796
	14714
	ENSG00000147437
	ENSMUSG00000015812
	P01148
	P13562
	NM_001083111; NM_000825
	NM_008145
	NP_000816; NP_001076580
	NP_032171
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

Gonadotropinen askapenerako hormona, hormona gonadotropina-askatzailea edo Gn-RH hipotalamoko polipeptidoa, hipofisiko aurreko lobulura iritsi eta bertan gonadoestimulinen (FSH edo hormona folikulu-estimulatzailearen eta LH edo hormona luteinizatzailearen) sintesia eta liberazioa eragiten dituen hormona da.^[6]

Egitura

Berez, 10 aminoazido ditu:

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly·NH2

GNRH1 gena Gn-RH hormonaren aitzindaria 8. kromosoman dago. 1977an deskribatu zuten Roger Guillemin eta Andrew V. Schally Nobel saridunek.

Erreferentziak

↑ Genetikoki lotutako gaixotasunak GNRH1ikusi/editatu erreferentziak Wikidatan. .
↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147437 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015812 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Euskalterm: [Ginekologia Hiztegia] [2015]

Kanpo estekak

Datuak: Q318896

Artikulu hau anatomiari buruzko zirriborroa da. Wikipedia lagun dezakezu edukia osatuz.

[1] Genetikoki lotutako gaixotasunak GNRH1ikusi/editatu erreferentziak Wikidatan. .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000147437 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000015812 – Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Euskalterm: [Ginekologia Hiztegia] [2015]

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