NBUMP: Difference between revisions
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Updating {{drugbox}} (no changed fields - added verified revid - updated 'UNII_Ref', 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation ( |
Importing Wikidata short description: "Chemical compound" |
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{{Short description|Chemical compound}} |
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{{Drugbox |
{{Drugbox |
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| verifiedrevid = |
| verifiedrevid = 424813377 |
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| IUPAC_name |
| IUPAC_name = ''N''-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]adamantane-1-carboxamide |
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| image |
| image = NBUMP.png |
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| CAS_number = ? |
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<!--Clinical data--> |
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| molecular_weight = 425.607 g/mol |
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| smiles = |
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<!--Pharmacokinetic data--> |
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| bioavailability |
| bioavailability = |
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| metabolism |
| metabolism = |
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| elimination_half-life = |
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| excretion = |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|CAS}} |
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| CAS_number = 134390-72-0 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = G184WXO36J |
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| ChemSpiderID = 58183 |
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<!--Chemical data--> |
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| smiles = COc1ccccc1N2CCN(CC2)CCCCNC(=O)C34CC5CC(C3)CC(C5)C4 |
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| StdInChI = 1S/C26H39N3O2/c1-31-24-7-3-2-6-23(24)29-12-10-28(11-13-29)9-5-4-8-27-25(30)26-17-20-14-21(18-26)16-22(15-20)19-26/h2-3,6-7,20-22H,4-5,8-19H2,1H3,(H,27,30) |
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| StdInChIKey = PRZPXKIXNNNNCD-UHFFFAOYSA-N |
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'''NBUMP''' is a highly [[binding selectivity|selective]] [[5-HT1A receptor|5-HT<sub>1A</sub> receptor]] [[partial agonist]] (K<sub>i</sub> = 0.1 nM; IA = 40%) with an [[aryl]][[piperazine]] structure.<ref name="isbn1-58829-568-0">{{cite book | |
'''NBUMP''' is a highly [[binding selectivity|selective]] [[5-HT1A receptor|5-HT<sub>1A</sub> receptor]] [[partial agonist]] (K<sub>i</sub> = 0.1 nM; IA = 40%) with an [[aryl]][[piperazine]] structure.<ref name="isbn1-58829-568-0">{{cite book | vauthors = Glennon RA | chapter = Strategies for the development of selective serotonergic agents|editor1-link=Bryan Roth | veditors = Roth BL | title = The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (The Receptors) | publisher = Humana Press | location = Totowa, NJ | year = 2006 | isbn = 1-58829-568-0 | chapter-url = https://books.google.com/books?id=J6i6YpvCQfIC&q=NBUMP&pg=PA113 | page = 113 }}</ref> It is one of the highest [[affinity (pharmacology)|affinity]] ligands for the 5-HT<sub>1A</sub> receptor known.<ref name="isbn1-58829-568-0" /> It displays 460- and 260-fold selectivity for 5-HT<sub>1A</sub> over the [[alpha-1 adrenergic receptor|α<sub>1</sub>-adrenergic]] and [[D2 receptor|D<sub>2</sub> receptor]]s, respectively.<ref name="isbn1-58829-568-0" /> |
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== See also == |
== See also == |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist}} |
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{{Serotonergics}} |
{{Serotonergics}} |
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{{Piperazines}} |
{{Piperazines}} |
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[[Category: |
[[Category:Phenylpiperazines]] |
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[[Category:5-HT1A agonists]] |
[[Category:5-HT1A agonists]] |
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[[Category:Serotonin receptor agonists]] |
[[Category:Serotonin receptor agonists]] |