Integrin alpha 5

ITGA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4
Identifiers
Aliases	ITGA5, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5
External IDs	OMIM: 135620; MGI: 96604; HomoloGene: 20508; GeneCards: ITGA5; OMA:ITGA5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,419,266 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,275,190 bp
RNA expression pattern
	Top expressed in
	tibial arteries; ; saphenous vein; ; muscle layer of sigmoid colon; ; Descending thoracic aorta; ; stromal cell of endometrium; ; ascending aorta; ; smooth muscle tissue; ; left uterine tube; ; upper lobe of left lung; ; right lung;
	Top expressed in
	tail of embryo; ; decidua; ; ascending aorta; ; aortic valve; ; gastrula; ; stroma of bone marrow; ; yolk sac; ; genital tubercle; ; atrium; ; urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor receptor 2 binding; virus receptor activity; epidermal growth factor receptor binding; metal ion binding; platelet-derived growth factor receptor binding; integrin binding; protein binding; cell adhesion molecule binding;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; alphav-beta3 integrin-vitronectin complex; membrane; cell-cell junction; ruffle; plasma membrane; synapse; ruffle membrane; cell surface; integrin complex; endoplasmic reticulum; cytoplasmic vesicle; external side of plasma membrane; focal adhesion; cell junction;
Biological process	leukocyte cell-cell adhesion; positive regulation of vascular endothelial growth factor receptor signaling pathway; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; endodermal cell differentiation; positive regulation of cell migration; heterotypic cell-cell adhesion; wound healing, spreading of epidermal cells; extracellular matrix organization; memory; cell-cell adhesion mediated by integrin; positive regulation of sprouting angiogenesis; cell-substrate adhesion; cell adhesion; angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; cell-substrate junction assembly; integrin-mediated signaling pathway; viral entry into host cell; viral process; negative regulation of anoikis; leukocyte migration; positive regulation of cell-substrate adhesion; regulation of angiogenesis; cell adhesion mediated by integrin; female pregnancy;
	Sources:Amigo / QuickGO
Orthologs
	3678
	16402
	ENSG00000161638
	ENSMUSG00000000555
	P08648
	P11688
	NM_002205
	NM_010577; NM_001314041
	NP_002196
	NP_001300970; NP_034707
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.^[5]

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[6]

Interactions

ITGA5 has been shown to interact with GIPC1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161638 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000555 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
^ "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".
^ Tani TT, Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. 276 (39). United States: 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

External links

CD49e+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGA5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161638 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000555 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2454952-5] Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.

[6] "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".

[pmid11479315-7] Tani TT, Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. 276 (39). United States: 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

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[7]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Integrin alpha 5

Interactions

See also

References

Further reading

External links