ERF (gene): Difference between revisions

ERF
Identifiers
Aliases	ERF, CRS4, PE-2, PE2, ETS2 repressor factor, CHYTS
External IDs	OMIM: 611888; MGI: 109637; HomoloGene: 68516; GeneCards: ERF; OMA:ERF - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,255,128 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,250,761 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastric mucosa; ; gallbladder; ; left uterine tube; ; ventricular zone; ; olfactory zone of nasal mucosa; ; anterior pituitary; ; body of uterus; ; tibial nerve; ; right ovary;
	Top expressed in
	genital tubercle; ; tail of embryo; ; yolk sac; ; ventricular zone; ; lip; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; perirhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription corepressor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; mitotic cell cycle; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2077
	13875
	ENSG00000105722
	ENSMUSG00000040857
	P50548
	P70459
	NM_001301035; NM_001308402; NM_001312656; NM_006494
	NM_010155
	NP_001287964; NP_001295331; NP_001299585; NP_006485
	NP_034285
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 17:25, 22 May 2016

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.^[5]^[6]^[7]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105722 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040857 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sgouras DN, Athanasiou MA, Beal GJ Jr, Fisher RJ, Blair DG, Mavrothalassitis GJ (Nov 1995). "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation". EMBO J. 14 (19): 4781–93. PMC 394576. PMID 7588608.
^ de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE (Sep 1997). "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)". Genomics. 42 (2): 227–35. doi:10.1006/geno.1997.4730. PMID 9192842.
^ "Entrez Gene: ERF Ets2 repressor factor".

External links

ERF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105722 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040857 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7588608-5] Sgouras DN, Athanasiou MA, Beal GJ Jr, Fisher RJ, Blair DG, Mavrothalassitis GJ (Nov 1995). "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation". EMBO J. 14 (19): 4781–93. PMC 394576. PMID 7588608.

[pmid9192842-6] Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE (Sep 1997). "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)". Genomics. 42 (2): 227–35. doi:10.1006/geno.1997.4730. PMID 9192842.

[entrez-7] "Entrez Gene: ERF Ets2 repressor factor".

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+{{Underlinked|date=May 2016}}
 {{DISPLAYTITLE:''ERF'' (gene)}}
 {{Infobox_gene}}
-'''ETS domain-containing transcription factor ERF''' is a [[protein]] that in humans is encoded by the ''ERF'' [[gene]].<ref name="pmid7588608">{{cite journal | author = Sgouras DN, Athanasiou MA, Beal GJ Jr, Fisher RJ, Blair DG, Mavrothalassitis GJ | title = ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation | journal = EMBO J | volume = 14 | issue = 19 | pages = 4781–93 |date=Nov 1995 | pmid = 7588608 | pmc = 394576 | doi =  }}</ref><ref name="pmid9192842">{{cite journal | author = de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE | title = Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF) | journal = Genomics | volume = 42 | issue = 2 | pages = 227–35 |date=Sep 1997 | pmid = 9192842 | pmc =  | doi = 10.1006/geno.1997.4730 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ERF Ets2 repressor factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2077| accessdate = }}</ref>
+'''ETS domain-containing transcription factor ERF''' is a [[protein]] that in humans is encoded by the ''ERF'' [[gene]].<ref name="pmid7588608">{{cite journal | vauthors = Sgouras DN, Athanasiou MA, ((Beal GJ Jr)), Fisher RJ, Blair DG, Mavrothalassitis GJ | title = ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation | journal = EMBO J | volume = 14 | issue = 19 | pages = 4781–93 |date=Nov 1995 | pmid = 7588608 | pmc = 394576 | doi =  }}</ref><ref name="pmid9192842">{{cite journal | vauthors = de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE | title = Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF) | journal = Genomics | volume = 42 | issue = 2 | pages = 227–35 |date=Sep 1997 | pmid = 9192842 | pmc =  | doi = 10.1006/geno.1997.4730 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ERF Ets2 repressor factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2077| accessdate = }}</ref>
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 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Liu D, Pavlopoulos E, Modi W |title=ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. |journal=Oncogene |volume=14 |issue= 12 |pages= 1445–51 |year= 1997 |pmid= 9136988 |doi= 10.1038/sj.onc.1200965 |display-authors=etal}}
+*{{cite journal  | vauthors=Liu D, Pavlopoulos E, Modi W |title=ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. |journal=Oncogene |volume=14 |issue= 12 |pages= 1445–51 |year= 1997 |pmid= 9136988 |doi= 10.1038/sj.onc.1200965 |display-authors=etal}}
-*{{cite journal  | author=Le Gallic L, Sgouras D, Beal G, Mavrothalassitis G |title=Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4121–33 |year= 1999 |pmid= 10330152 |doi=  | pmc=104371  }}
+*{{cite journal  | vauthors=Le Gallic L, Sgouras D, Beal G, Mavrothalassitis G |title=Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4121–33 |year= 1999 |pmid= 10330152 |doi=  | pmc=104371  }}
-*{{cite journal  | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
+*{{cite journal  | vauthors=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
-*{{cite journal  | author=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners. |journal=FEBS Lett. |volume=517 |issue= 1–3 |pages= 167–71 |year= 2002 |pmid= 12062430 |doi=10.1016/S0014-5793(02)02614-5  }}
+*{{cite journal  | vauthors=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners. |journal=FEBS Lett. |volume=517 |issue= 1–3 |pages= 167–71 |year= 2002 |pmid= 12062430 |doi=10.1016/S0014-5793(02)02614-5  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Bain M, Mendelson M, Sinclair J |title=Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells |journal=J. Gen. Virol. |volume=84 |issue= Pt 1 |pages= 41–9 |year= 2003 |pmid= 12533699 |doi=10.1099/vir.0.18633-0  }}
+*{{cite journal  | vauthors=Bain M, Mendelson M, Sinclair J |title=Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells |journal=J. Gen. Virol. |volume=84 |issue= Pt 1 |pages= 41–9 |year= 2003 |pmid= 12533699 |doi=10.1099/vir.0.18633-0  }}
-*{{cite journal  | author=Xiao X, Athanasiou M, Sidorov IA |title=Role of Ets/Id proteins for telomerase regulation in human cancer cells |journal=Exp. Mol. Pathol. |volume=75 |issue= 3 |pages= 238–47 |year= 2003 |pmid= 14611815 |doi=10.1016/S0014-4800(03)00092-3  |display-authors=etal}}
+*{{cite journal  | vauthors=Xiao X, Athanasiou M, Sidorov IA |title=Role of Ets/Id proteins for telomerase regulation in human cancer cells |journal=Exp. Mol. Pathol. |volume=75 |issue= 3 |pages= 238–47 |year= 2003 |pmid= 14611815 |doi=10.1016/S0014-4800(03)00092-3  |display-authors=etal}}
-*{{cite journal  | author=Wolvetang EJ, Bradfield OM, Hatzistavrou T |title=Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis |journal=Neurobiol. Dis. |volume=14 |issue= 3 |pages= 349–56 |year= 2004 |pmid= 14678752 |doi=10.1016/S0969-9961(03)00107-4  |display-authors=etal}}
+*{{cite journal  | vauthors=Wolvetang EJ, Bradfield OM, Hatzistavrou T |title=Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis |journal=Neurobiol. Dis. |volume=14 |issue= 3 |pages= 349–56 |year= 2004 |pmid= 14678752 |doi=10.1016/S0969-9961(03)00107-4  |display-authors=etal}}
-*{{cite journal  | author=Le Gallic L, Virgilio L, Cohen P |title=ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1206–18 |year= 2004 |pmid= 14729966 |doi=10.1128/MCB.24.3.1206-1218.2004  | pmc=321421  |display-authors=etal}}
+*{{cite journal  | vauthors=Le Gallic L, Virgilio L, Cohen P |title=ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1206–18 |year= 2004 |pmid= 14729966 |doi=10.1128/MCB.24.3.1206-1218.2004  | pmc=321421  |display-authors=etal}}
-*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |display-authors=etal}}
+*{{cite journal  | vauthors=Grimwood J, Gordon LA, Olsen A |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
+*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
+*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
-*{{cite journal  | author=Hester KD, Verhelle D, Escoubet-Lozach L |title=Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS |journal=Cell Cycle |volume=6 |issue= 13 |pages= 1594–604 |year= 2007 |pmid= 17525531 |doi=10.4161/cc.6.13.4336  |display-authors=etal}}
+*{{cite journal  | vauthors=Hester KD, Verhelle D, Escoubet-Lozach L |title=Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS |journal=Cell Cycle |volume=6 |issue= 13 |pages= 1594–604 |year= 2007 |pmid= 17525531 |doi=10.4161/cc.6.13.4336  |display-authors=etal}}
-*{{cite journal  | author=Verykokakis M, Papadaki C, Vorgia E |title=The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression |journal=J. Biol. Chem. |volume=282 |issue= 41 |pages= 30285–94 |year= 2007 |pmid= 17699159 |doi= 10.1074/jbc.M704428200 |display-authors=etal}}
+*{{cite journal  | vauthors=Verykokakis M, Papadaki C, Vorgia E |title=The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression |journal=J. Biol. Chem. |volume=282 |issue= 41 |pages= 30285–94 |year= 2007 |pmid= 17699159 |doi= 10.1074/jbc.M704428200 |display-authors=etal}}
 }}
 {{refend}}
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 * {{MeshName|ERF+protein,+human}}
-{{gene-19-stub}}
 {{NLM content}}
 {{Transcription factors|g3}}
-[[Category:Transcription factors]]
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+[[Category:Transcription factors]]
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Revision as of 17:25, 22 May 2016

References

Further reading

External links