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Ebright was appointed as a faculty member in the Department of Chemistry at [[Rutgers University]] and as a Laboratory Director at the [[Waksman Institute of Microbiology]] in 1987.<ref name="Waksman" /> He was co-appointed as an Investigator of the [[Howard Hughes Medical Institute]] from 1997 to 2013.<ref name="Waksman" />
Ebright was appointed as a faculty member in the Department of Chemistry at [[Rutgers University]] and as a Laboratory Director at the [[Waksman Institute of Microbiology]] in 1987.<ref name="Waksman" /> He was co-appointed as an Investigator of the [[Howard Hughes Medical Institute]] from 1997 to 2013.<ref name="Waksman" />


⚫
Ebright has performed research on [[protein-DNA interaction]],<ref name="Ebright">{{Cite journal | last1 = Ebright | first1 = R. H. | last2 = Cossart | first2 = P. | last3 = Gicquel-Sanzey | first3 = B. | last4 = Beckwith | first4 = J. | title = Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli | journal = Nature | volume = 311 | issue = 5983 | pages = 232–235 | year = 1984 | pmid = 6090927 | doi=10.1038/311232a0}}</ref><ref name="Blatter">{{cite journal|pmid=1406998 | doi=10.1038/359650a0 | volume=359 | title=Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking | year=1992 | journal=Nature | pages=650–2 | last1 = Blatter | first1 = E. | last2 = Ebright | first2 = Y. | last3 = Ebright | first3 = R. H.}}</ref><ref name="Pendergrast">{{cite journal|pmid=8052855 | doi=10.1126/science.8052855 | volume=265 | title=High-specificity DNA cleavage agent: design and application to kilobase and megabase DNA substrates | year=1994 | journal=Science | pages=959–62 | last1 = Pendergrast | first1 = P. S. | last2 = Ebright | first2 = Y. | last3 = Ebright | first3 = R. H.}}</ref>
Ebright has performed research on [[protein-DNA interaction]],<ref name="Ebright">{{Cite journal
[[transcription (genetics)|transcription initiation]],<ref name="Naryshkin">{{cite journal | last1 = Naryshkin | first1 = N. | last2 = Revyakin | first2 = A. | last3 = Kim | first3 = Y. | last4 = Mekler | first4 = V. | last5 = Ebright | first5 = R. H. | year = 2000 | title = Structural organization of the RNA polymerase-promoter open complex | url = | journal = Cell | volume = 101 | issue = 6| pages = 601–611 | doi = 10.1016/S0092-8674(00)80872-7 | pmid = 10892647}}</ref><ref name="Mekler">{{cite journal | last1 = Mekler | first1 = V. | last2 = Kortkhonjia | first2 = E. | last3 = Mukhopadhyay | first3 = J. | last4 = Knight | first4 = J. | last5 = Revyakin | first5 = A. | last6 = Kapanidis | first6 = A. | last7 = Niu | first7 = W. | last8 = Ebright | first8 = Y. | last9 = Levy | first9 = R. | last10 = Ebright | first10 = R. H.| year = 2002 | title = Structural organization of bacterial RNA polymerase holoenzyme and the RNA polymerase-promoter open complex | url = | journal = Cell | volume = 108 | issue = 5| pages = 599–614 | doi = 10.1016/S0092-8674(02)00667-0 | pmid = 11893332 }}</ref><ref name="Kapanidis">{{cite journal |author1=Kapanidis, A. N. |author2=Margeat, E. |author3=Ho, S. O. |author4=Kortkhonjia, E. |author5=Weiss, S. |author6=Ebright, R. H. |year=2006 |title=Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism |journal=Science |volume=314 |pages=1144–1147 |pmid=17110578 |doi=10.1126/science.1131399 |pmc=2754788 }}</ref><ref name="Revyakin">{{cite journal |author1=Revyakin, A. |author2=Liu, C. |author3=Ebright, R. H. |author4=Strick, T. | year = 2006 | title = Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching | url = | journal = Science | volume = 314 | issue = 5802| pages = 1139–1143 | doi = 10.1126/science.1131398 | pmid = 17110577 | pmc = 2754787 | bibcode = 2006Sci...314.1139R }}</ref><ref name="Chakraborty">{{cite journal | last1 = Chakraborty | first1 = A. | last2 = Wang | first2 = D. | last3 = Ebright | first3 = Y. | last4 = Korlann | first4 = Y. | last5 = Kortkhonjia | first5 = E. | last6 = Kim | first6 = T. | last7 = Chowdhury | first7 = S. | last8 = Wigneshweraraj | first8 = S. | last9 = Irschik | first9 = H. | last10 = Jansen | first10 = R. | last11 = Nixon | first11 = B.T. | last12 = Knight | first12 = J. | last13 = Weiss | first13 = S. | last14 = Ebright | first14 = R. H.| year = 2012 | title = Opening and closing of the bacterial RNA polymerase clamp | url = | journal = Science | volume = 337 | issue = 6094| pages = 591–595 | doi = 10.1126/science.1218716 | pmid = 22859489 | pmc = 3626110 }}</ref><ref name="Zhang">{{Cite journal | last1 = Zhang | first1 = Y. | last2 = Feng | first2 = Y. | last3 = Chatterjee | first3 = S. | last4 = Tuske | first4 = S. | last5 = Ho | first5 = M. X. | last6 = Arnold | first6 = E. | last7 = Ebright | first7 = R. H. | doi = 10.1126/science.1227786 | title = Structural Basis of Transcription Initiation | journal = Science | year = 2012 | pmid = 23086998 | pmc = 3593053| volume=338 | issue=6110 | pages=1076–80}}</ref><ref name="Winkelman">{{cite journal | last1=Winkelman| first1=J.| last2=Vvedenskaya| first2=I.| last3=Zhang| first3=Y.| last4=Bird| first4=J.| last5=Taylor| first5=D.| last6=Gourse| first6=R.| last7=Ebright| first7=R.| last8=Nickels| first8=B.| year=2016| title=Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection| journal=Science| volume=351| issue=6277 | pages=1090–1093| doi=10.1126/science.aad6881 | pmid=26941320 | pmc=4797950}}</ref>
| last1 = Ebright | first1 = R. H.
[[activator (genetics)|transcription activation]],<ref name="Heyduk">{{cite journal | last1 = Heyduk | first1 = T. | last2 = Lee | first2 = J. | last3 = Ebright | first3 = Y. | last4 = Blatter | first4 = E. | last5 = Zhou | first5 = Y. | last6 = Ebright | first6 = R. H.| year = 1993 | title = CAP interacts with RNA polymerase in solution in the absence of promoter DNA | url = | journal = Nature | volume = 364 | issue = 6437| pages = 548–549 | doi = 10.1038/364548a0 | pmid = 8393148 }}</ref><ref name ="Zhou">{{cite journal | last1 = Zhou | first1 = Y. | last2 = Busby | first2 = S. | last3 = Ebright | first3 = R. H.| year = 1993 | title = Identification of the functional subunit of a dimeric transcription activator protein by use of "oriented heterodimers | url = | journal = Cell | volume = 73 | issue = 2| pages = 375–379 | doi = 10.1016/0092-8674(93)90236-J | pmid = 8477449 }}</ref><ref name="Chan">{{cite journal | last1 = Chen | first1 = Y. | last2 = Ebright | first2 = Y. | last3 = Ebright | first3 = R. H.| year = 1994 | title = Identification of the target of a transcription activator protein by protein-protein photocrosslinking | url = | journal = Science | volume = 265 | issue = 5168| pages = 90–92 | doi = 10.1126/science.8016656 | pmid = 8016656 }}</ref><ref>{{cite journal | last1 = Niu | first1 = W. | last2 = Kim | first2 = Y. | last3 = Tau | first3 = G. | last4 = Heyduk | first4 = T. | last5 = Ebright | first5 = R. H.| year = 1996 | title = Transcription activation at Class II CAP-dependent promoters: two interactions between CAP and RNA polymerase | url = | journal = Cell | volume = 87 | issue = 6| pages = 1123–1134 | doi = 10.1016/S0092-8674(00)81806-1 | pmid = 8978616 | pmc = 4430116 }}</ref><ref name="Benoff">{{cite journal |author1=Benoff, B. |author2=Yang, H. |author3=Lawson, C. L. |author4=Parkinson, G. |author5=Liu, J. |author6=Blatter, E. |author7=Ebright, Y. W. |author8=Berman, H. M. |author9=Arnold, E. |author10=Ebright, R. H. |year=2002 |title=Structural basis of transcription activation: the CAP-alphaCTD-DNA complex |journal=Science |volume=297 |issue=5586 |pages=1562–1566 |PMID=12202833 |doi=10.1126/science.1076376 |bibcode=2002Sci...297.1562B }}</ref><ref name="Feng">{{cite journal |author1=Feng, Y. |author2=Zhang, Y. |author3=Ebright, R. H. |year=2016 |title=Structural basis of transcription activation |journal=Science |volume=352 |issue=6291 |pages=1330–1333 |doi=10.1126/science.aaf4417 |pmid= 27284196 |pmc=4905602}}</ref>
| last2 = Cossart | first2 = P.
transcription-translation coupling,<ref name="Wang">{{cite journal |author1=Wang, C. |author2=Molodtsov, V. |author3=Firlar, E.|author4=Kaelber, J. |author5=Blaha, G. |author6=Su, M. |author7=Ebright, R. H. |lastauthoramp=yes |year=2020 |title=Structural basis of transcription-translation coupling |journal=Science |doi=10.1126/science.abb5317 |pmid=32820061 }}</ref>
| last3 = Gicquel-Sanzey | first3 = B.
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and [[antibacterial]] drug discovery.<ref name="Mukhopadhyay">{{cite journal |author1=Mukhopadhyay, J. |author2=Das, K. |author3=Ismail, S. |author4=Koppstein, D. |author5=Jang, M. |author6=Hudson, B. |author7=Sarafianos, S. |author8=Tuske, S. |author9=Patel, J. |author10=Jansen, R. |author11=Irschik, H. |author12=Arnold, E. |author13=Ebright, R. H. |lastauthoramp=yes |year=2008 |title=The RNA polymerase "switch region" is a target for inhibitors |journal=Cell |volume=135 |issue=2 |pages=295–307 |doi=10.1016/j.cell.2008.09.033 |pmc=2580802 |pmid=18957204 }}</ref><ref name="GE23077">{{cite journal |author1=Zhang, Y. |author2=Degen, D. |author3=Ho, M. X. |author4=Sineva, E. |author5=Ebright, K. |author6=Ebright, Y. W. |author7=Mekler, V. |author8=Vahedian-Movahed, H. |author9=Feng, Y. |author10=Yin, R. |author11=Tuske, S. |author12=Irschik, H. |author13=Jansen, R. |author14=Maffioli, S. |author15=Donadio, S. |author16=Arnold, E. |author17=Ebright, R. H. | year = 2014 | title = GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides | url = | journal = eLife | volume = 3 | pages = e02450 | doi = 10.7554/eLife.02450 | pmid = 24755292 | pmc = 3994528}}</ref><ref name = "Feng Sal">{{cite journal | last1 = Degen | first1= D. | last2 = Feng | first2 = Y. | last3 = Zhang | first3 = Y. | last4 = Ebright | first4 = K. | last5 = Ebright | first5 = Y. | last6 = Gigliotti | first6 = M. | last7 = Vahedian-Movahed | first7 = H. |last8 = Mandal | first8 = S. | last9 = Talaue | first9 = M. | last10 = Connell | first10 = N. | last11 = Arnold | first11 = E. | last12 = Fenical | first12 = W. | last13 = Ebright | first13 = R. |year = 2014 | title = Transcription inhibition by the depsipeptide antibiotic salinamide A | journal = eLife | volume = 3 | pages = e02451 | doi = 10.7554/eLife.02451 | pmid = 24843001 | pmc = 4029172 }}</ref><ref name="Lin">{{cite journal |author1=Lin, W. |author2=Mandal, S. |author3=Degen, D. |author4=Liu, Y. |author5=Ebright, Y. W. |author6=Li. S. |author7=Feng, Y. |author8=Zhang, Y. |author9=Mandal, S. |author10=Jiang, Y. |author11=Liu, S. |author12=Gigliotti, M. |author13=Talaue, M. |author14=Connell, N. |author15=Das, K. |author16=Arnold, E. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition |journal=Mol. Cell |volume=66 |pages=169–179 |doi=10.1016/j.molcel.2017.03.001 | pmid = 28392175 | pmc = 5438085 }}</ref><ref name="Maffioli">{{cite journal |author1=Maffioli, S. |author2=Zhang, Y. |author3=Degen, D. |author4=Carzaniga, T. |author5=Del Gatto, G. |author6=Serina, S. |author7=Monciardini, P. |author8=Mazzetti, C. |author9=Guglierame, P. |author10=Candiani, G. |author11=Chiriac, A. I. |author12=Facchetti, G. |author13=Kaltofen, P. |author14=Sahl, H.-G. |author15=Dehò, G. |author16=Donadio, S. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase |journal=Cell |volume=169 |issue=7 |pages=1240–1248 |doi=10.1016/j.cell.2017.05.042 |pmid=28622509 |pmc=5542026}}</ref><ref name="Lin2018">{{cite journal |author1=Lin, W. |author2=Das, K. |author3=Degen, D. |author4=Mazumder, A. |author5=Duchi, D. |author6=Wang, D. |author7=Ebright, Y. |author8=Ebright, R.Y. |author9=Sineva, E. |author10=Gigliotti, M. |author11=Srivastava, A. |author12=Mandal, S. |author13=Jiang, Y. |author14=Liu, Y. |author15=Yin, R. |author16=Zhang, Z. |author17=Eng, E. |author18=Thomas, D. |author19=Donadio, S. |author20=Zhang, H. |author21=Zhang, C. |author22=Kapanidis, A. |author23=Ebright, R. H. |lastauthoramp=yes |year=2018 |title=Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) |journal=Mol. Cell |volume=70 |issue=1 |pages=60–71 |doi=10.1016/j.molcel.2018.02.026 |pmid=29606590|pmc=6205224 }}</ref>
| last4 = Beckwith | first4 = J.
Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,<ref name="Ebright"/> the determination of the three-dimensional structural organization of the transcription initiation complex;<ref name="Naryshkin"/><ref name="Mekler"/><ref name="Chakraborty"/><ref name="Zhang"/> the demonstration that transcription start-site selection and [[abortive initiation|initial transcription]] involve a "[[DNA scrunching]]" mechanism;<ref name="Kapanidis"/><ref name="Revyakin"/><ref name="Winkelman"/> the demonstration that transcription activation can proceed by a "recruitment" mechanism;<ref name="Heyduk"/><ref name="Zhou"/><ref name="Chan"/><ref name="Benoff"/><ref name="Feng" /> the demonstration that bacterial transcription-translation coupling involves direct physical bridging of [[RNA polymerase]] and a [[ribosome]] by NusA and NusG<ref name="Wang"/>; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.<ref name="Mukhopadhyay"/><ref name="GE23077"/><ref name="Feng Sal"/><ref name="Lin"/><ref name="Maffioli"/><ref name="Lin2018"/>
| title = Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli
| journal = Nature
| volume = 311
| issue = 5983
| pages = 232–235
| year = 1984
| pmid = 6090927 | doi=10.1038/311232a0
⚫
}}</ref><!--<ref>{{cite journal|pmid=6390433 | volume=81 | title=Molecular basis of DNA sequence recognition by the catabolite gene activator protein: detailed inferences from three mutations that alter DNA sequence specificity | pmc=392128 | date=December 1984 | journal=Proc. Natl. Acad. Sci. U.S.A. | pages=7274–8 | last1 = Ebright | first1 = RH | last2 = Cossart | first2 = P | last3 = Gicquel-Sanzey | first3 = B | last4 = Beckwith | first4 = J | doi = 10.1073/pnas.81.23.7274}}</ref><ref>{{cite journal|pmid=3510433 | volume=83 | title=Evidence for a contact between glutamine-18 of lac repressor and base pair 7 of lac operator | pmc=322846 | date=January 1986 | journal=Proc. Natl. Acad. Sci. U.S.A. | pages=303–7 | last1 = Ebright | first1 = RH | doi=10.1073/pnas.83.2.303}}</ref><ref>{{cite journal|pmid=1406998 | doi=10.1038/359650a0 | volume=359 | title=Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking | date=October 1992 | journal=Nature | pages=650–2 | last1 = Blatter | first1 = EE | last2 = Ebright | first2 = YW | last3 = Ebright | first3 = RH}}</ref><ref>{{cite journal|pmid=8052855 | doi=10.1126/science.8052855 | volume=265 | title=High-specificity DNA cleavage agent: design and application to kilobase and megabase DNA substrates | date=August 1994 | journal=Science | pages=959–62 | last1 = Pendergrast | first1 = PS | last2 = Ebright | first2 = YW | last3 = Ebright | first3 = RH}}</ref>--> [[transcription (genetics)|transcription initiation]],<ref name="Zhang">{{Cite journal
| last1 = Zhang | first1 = Y.
| last2 = Feng | first2 = Y.
| last3 = Chatterjee | first3 = S.
| last4 = Tuske | first4 = S.
| last5 = Ho | first5 = M. X.
| last6 = Arnold | first6 = E.
| last7 = Ebright | first7 = R. H.
| doi = 10.1126/science.1227786
| title = Structural Basis of Transcription Initiation
| journal = Science
| year = 2012
| pmid = 23086998
| pmc = 3593053| volume=338 | issue=6110 | pages=1076–80
⚫
}}</ref><ref name="Kapanidis">{{cite journal |author1=Kapanidis, A. N. |author2=Margeat, E. |author3=Ho, S. O. |author4=Kortkhonjia, E. |author5=Weiss, S. |author6=Ebright, R. H. |year=2006 |title=Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism |journal=Science |volume=314 |pages=1144–1147 |pmid=17110578 |doi=10.1126/science.1131399 |pmc=2754788 }}</ref><ref name="Revyakin">{{cite journal |author1=Revyakin, A. |author2=Liu, C. |author3=Ebright, R. H. |author4=Strick, T. | year = 2006 | title = Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching | url = | journal = Science | volume = 314 | issue = 5802| pages = 1139–1143 | doi = 10.1126/science.1131398 | pmid = 17110577 | pmc = 2754787 | bibcode = 2006Sci...314.1139R }}</ref> [[activator (genetics)|transcription activation]],<ref name="Benoff">{{cite journal |author1=Benoff, B. |author2=Yang, H. |author3=Lawson, C. L. |author4=Parkinson, G. |author5=Liu, J. |author6=Blatter, E. |author7=Ebright, Y. W. |author8=Berman, H. M. |author9=Arnold, E. |author10=Ebright, R. H. |year=2002 |title=Structural basis of transcription activation: the CAP-alphaCTD-DNA complex |journal=Science |volume=297 |issue=5586 |pages=1562–1566 |PMID=12202833 |doi=10.1126/science.1076376 |bibcode=2002Sci...297.1562B }}</ref><ref name="Feng">{{cite journal |author1=Feng, Y. |author2=Zhang, Y. |author3=Ebright, R. H. |year=2016 |title=Structural basis of transcription activation |journal=Science |volume=352 |issue=6291 |pages=1330–1333 |doi=10.1126/science.aaf4417 |pmid= 27284196 |pmc=4905602}}</ref> transcription-translation coupling,<ref name="Wang">{{cite journal |author1=Wang, C. |author2=Molodtsov, V. |author3=Firlar, E.|author4=Kaelber, J. |author5=Blaha, G. |author6=Su, M. |author7=Ebright, R. H. |lastauthoramp=yes |year=2020 |title=Structural basis of transcription-translation coupling |journal=Science |doi=10.1126/science.abb5317 |pmid=32820061 }}</ref> and [[antibacterial]] drug discovery.<ref name="Mukhopadhyay">{{cite journal |author1=Mukhopadhyay, J. |author2=Das, K. |author3=Ismail, S. |author4=Koppstein, D. |author5=Jang, M. |author6=Hudson, B. |author7=Sarafianos, S. |author8=Tuske, S. |author9=Patel, J. |author10=Jansen, R. |author11=Irschik, H. |author12=Arnold, E. |author13=Ebright, R. H. |lastauthoramp=yes |year=2008 |title=The RNA polymerase "switch region" is a target for inhibitors |journal=Cell |volume=135 |issue=2 |pages=295–307 |doi=10.1016/j.cell.2008.09.033 |pmc=2580802 |pmid=18957204 }}</ref><ref name="GE23077">{{cite journal |author1=Zhang, Y. |author2=Degen, D. |author3=Ho, M. X. |author4=Sineva, E. |author5=Ebright, K. |author6=Ebright, Y. W. |author7=Mekler, V. |author8=Vahedian-Movahed, H. |author9=Feng, Y. |author10=Yin, R. |author11=Tuske, S. |author12=Irschik, H. |author13=Jansen, R. |author14=Maffioli, S. |author15=Donadio, S. |author16=Arnold, E. |author17=Ebright, R. H. | year = 2014 | title = GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides | url = | journal = eLife | volume = 3 | pages = e02450 | doi = 10.7554/eLife.02450 | pmid = 24755292 | pmc = 3994528}}</ref><ref name = "Feng Sal">{{cite journal | last1 = Degen | first1= D. | last2 = Feng | first2 = Y. | last3 = Zhang | first3 = Y. | last4 = Ebright | first4 = K. | last5 = Ebright | first5 = Y. | last6 = Gigliotti | first6 = M. | last7 = Vahedian-Movahed | first7 = H. |last8 = Mandal | first8 = S. | last9 = Talaue | first9 = M. | last10 = Connell | first10 = N. | last11 = Arnold | first11 = E. | last12 = Fenical | first12 = W. | last13 = Ebright | first13 = R. |year = 2014 | title = Transcription inhibition by the depsipeptide antibiotic salinamide A | journal = eLife | volume = 3 | pages = e02451 | doi = 10.7554/eLife.02451 | pmid = 24843001 | pmc = 4029172 }}</ref><ref name="Lin">{{cite journal |author1=Lin, W. |author2=Mandal, S. |author3=Degen, D. |author4=Liu, Y. |author5=Ebright, Y. W. |author6=Li. S. |author7=Feng, Y. |author8=Zhang, Y. |author9=Mandal, S. |author10=Jiang, Y. |author11=Liu, S. |author12=Gigliotti, M. |author13=Talaue, M. |author14=Connell, N. |author15=Das, K. |author16=Arnold, E. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition |journal=Mol. Cell |volume=66 |pages=169–179 |doi=10.1016/j.molcel.2017.03.001 | pmid = 28392175 | pmc = 5438085 }}</ref><ref name="Maffioli">{{cite journal |author1=Maffioli, S. |author2=Zhang, Y. |author3=Degen, D. |author4=Carzaniga, T. |author5=Del Gatto, G. |author6=Serina, S. |author7=Monciardini, P. |author8=Mazzetti, C. |author9=Guglierame, P. |author10=Candiani, G. |author11=Chiriac, A. I. |author12=Facchetti, G. |author13=Kaltofen, P. |author14=Sahl, H.-G. |author15=Dehò, G. |author16=Donadio, S. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase |journal=Cell |volume=169 |issue=7 |pages=1240–1248 |doi=10.1016/j.cell.2017.05.042 |pmid=28622509 |pmc=5542026}}</ref><ref name="Lin2018">{{cite journal |author1=Lin, W. |author2=Das, K. |author3=Degen, D. |author4=Mazumder, A. |author5=Duchi, D. |author6=Wang, D. |author7=Ebright, Y. |author8=Ebright, R.Y. |author9=Sineva, E. |author10=Gigliotti, M. |author11=Srivastava, A. |author12=Mandal, S. |author13=Jiang, Y. |author14=Liu, Y. |author15=Yin, R. |author16=Zhang, Z. |author17=Eng, E. |author18=Thomas, D. |author19=Donadio, S. |author20=Zhang, H. |author21=Zhang, C. |author22=Kapanidis, A. |author23=Ebright, R. H. |lastauthoramp=yes |year=2018 |title=Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) |journal=Mol. Cell |volume=70 |issue=1 |pages=60–71 |doi=10.1016/j.molcel.2018.02.026 |pmid=29606590|pmc=6205224 }}</ref> Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,<ref name="Ebright"/> the determination of the three-dimensional structural organization of the transcription initiation complex;<ref name="Zhang" /> the demonstration that [[abortive initiation|initial transcription]] involves a "[[DNA scrunching]]" mechanism;<ref name="Kapanidis" /><ref name="Revyakin" /> the demonstration that transcription activation can proceed by a "recruitment" mechanism;<ref name="Benoff" /><ref name="Feng" /> the demonstration that bacterial transcription-translation coupling involves direct physical bridging of [[RNA polymerase]] and a [[ribosome]] by NusA and NusG<ref name="Wang" />; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.<ref name="Mukhopadhyay" /><ref name="GE23077" /><ref name="Feng Sal" /><ref name="Lin" /><ref name="Maffioli" /><ref name="Lin2018" />


In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.<ref name="ASBMB">{{cite web |title=ASBMB/Schering-Plough Research Institute Award |url=http://www.asbmb.org/Page.aspx?id=510 |accessdate=October 8, 2011 }}</ref> In 1995 he received the Academic Press Walter J. Johnson Prize.<ref>{{Cite journal
In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.<ref name="ASBMB">{{cite web |title=ASBMB/Schering-Plough Research Institute Award |url=http://www.asbmb.org/Page.aspx?id=510 |accessdate=October 8, 2011 }}</ref> In 1995 he received the Academic Press Walter J. Johnson Prize.<ref>{{Cite journal
⚫
| title = The Walter J. Johnson Prize, 1995 | journal = Journal of Molecular Biology | volume = 251 | issue = 3 | pages = 329 | year = 1995 | pmid = 7650734}}</ref> In 2013 he received a National Institutes of Health MERIT Award.<ref>{{cite news |title=Gifts & Grants |url=http://bulletin.rutgers.edu/bulletin-sections/gifts-grants |newspaper=Rutgers University Faculty and Staff Bulletin |date=June 12, 2013 |accessdate=June 12, 2013 }}</ref> He was elected as a Fellow of the American Academy of Microbiology in 1996,<ref name="AAM">{{cite web |title=American Academy of Microbiology Fellowship Directory |url=http://academy.asm.org/index.php/fellows/fellows-directory |accessdate=October 8, 2011 |url-status=dead |archiveurl=https://web.archive.org/web/20110807112021/http://academy.asm.org/index.php/fellows/fellows-directory |archivedate=August 7, 2011 }}</ref> the American Association for the Advancement of Science in 2004,<ref>{{cite press release |title=AAAS Council Honors 308 Members for Their Contributions to Science |url=http://www.aaas.org/news/releases/2004/1101fellows.shtml |publisher=AAAS |date= November 1, 2004 |accessdate=October 8, 2011 }}</ref> the Infectious Diseases Society of America in 2011,<ref>{{cite news |title=Congratulations, New IDSA Fellows! |url=http://news.idsociety.org/idsa/issues/2011-08-02/14.html |newspaper=IDSA News |date=July–August 2011 |accessdate=October 8, 2011 }}</ref> and the American Academy of Arts and Sciences in 2016.<ref>{{cite press release |title=American Academy of Arts and Sciences Elects 213 National and International Scholars, Artists, Philanthropists, and Business and Civic Leaders |url=https://www.amacad.org/content/news/pressReleases.aspx?pr=10257 |publisher=American Academy of Arts and Sciences |date=April 20, 2016 |accessdate=April 20, 2016 }}</ref>
| title = The Walter J. Johnson Prize, 1995
| journal = Journal of Molecular Biology
| volume = 251
| issue = 3
| pages = 329
| year = 1995
| pmid = 7650734
⚫
}}</ref> In 2013 he received a National Institutes of Health MERIT Award.<ref>{{cite news |title=Gifts & Grants |url=http://bulletin.rutgers.edu/bulletin-sections/gifts-grants |newspaper=Rutgers University Faculty and Staff Bulletin |date=June 12, 2013 |accessdate=June 12, 2013 }}</ref> He was elected as a Fellow of the American Academy of Microbiology in 1996,<ref name="AAM">{{cite web |title=American Academy of Microbiology Fellowship Directory |url=http://academy.asm.org/index.php/fellows/fellows-directory |accessdate=October 8, 2011 |url-status=dead |archiveurl=https://web.archive.org/web/20110807112021/http://academy.asm.org/index.php/fellows/fellows-directory |archivedate=August 7, 2011 }}</ref> the American Association for the Advancement of Science in 2004,<ref>{{cite press release |title=AAAS Council Honors 308 Members for Their Contributions to Science |url=http://www.aaas.org/news/releases/2004/1101fellows.shtml |publisher=AAAS |date= November 1, 2004 |accessdate=October 8, 2011 }}</ref> the Infectious Diseases Society of America in 2011,<ref>{{cite news |title=Congratulations, New IDSA Fellows! |url=http://news.idsociety.org/idsa/issues/2011-08-02/14.html |newspaper=IDSA News |date=July–August 2011 |accessdate=October 8, 2011 }}</ref> and the American Academy of Arts and Sciences in 2016.<ref>{{cite press release |title=American Academy of Arts and Sciences Elects 213 National and International Scholars, Artists, Philanthropists, and Business and Civic Leaders |url=https://www.amacad.org/content/news/pressReleases.aspx?pr=10257 |publisher=American Academy of Arts and Sciences |date=April 20, 2016 |accessdate=April 20, 2016 }}</ref>


Ebright has opposed the proliferation of laboratories working on [[biological weapons]] agents<ref>{{cite journal |last1=Connell |first1=N. |last2=Ebright |first2=R. H. |year=2002 |title=Bioweapon agents: more access means more risk |journal=Nature |volume=415 |pages=364 |pmid=11807521 |doi=10.1038/415364b |issue=6870 | bibcode = 2002Natur.415..364E |doi-access=free }}</ref> and has supported the strengthening of [[biosafety]] and [[biosecurity]] measures to reduce risks of release of [[biological weapons]].<ref>{{cite journal |last=Ebright |first=R. H. |year=2012 |title=Mitigate the risks of release |journal=Nature |volume=481 |pages=257–259 |pmid=22246325 |doi=10.1038/481257a|pmc=7095491 }}</ref>
Ebright has opposed the proliferation of laboratories working on [[biological weapons]] agents<ref>{{cite journal |last1=Connell |first1=N. |last2=Ebright |first2=R. H. |year=2002 |title=Bioweapon agents: more access means more risk |journal=Nature |volume=415 |pages=364 |pmid=11807521 |doi=10.1038/415364b |issue=6870 | bibcode = 2002Natur.415..364E |doi-access=free }}</ref> and has supported the strengthening of [[biosafety]] and [[biosecurity]] measures to reduce risks of release of [[biological weapons]].<ref>{{cite journal |last=Ebright |first=R. H. |year=2012 |title=Mitigate the risks of release |journal=Nature |volume=481 |pages=257–259 |pmid=22246325 |doi=10.1038/481257a|pmc=7095491 }}</ref>

Revision as of 00:39, 26 August 2020

Richard H. Ebright
Born (1959-06-11) June 11, 1959 (age 65)
NationalityAmerican
CitizenshipAmerican
Alma mater
Scientific career
FieldsBiology, Molecular Biology
Institutions

Richard H. Ebright is an American molecular biologist. He is the Board of Governors Professor of Chemistry and Chemical Biology at Rutgers University and Laboratory Director at the Waksman Institute of Microbiology.[1][2]

Early life and education

Richard H. Ebright was born on 11 June 1959 to Richard J. Ebright and Jacqueline K. Ebright.

Ebright received an A.B. summa cum laude in biology from Harvard University in 1981 and a Ph.D. in Microbiology and Molecular Genetics from Harvard University in 1987.[1][2] He was a Junior Fellow of the Harvard Society of Fellows from 1984 to 1987.[1]

Career

Ebright was appointed as a faculty member in the Department of Chemistry at Rutgers University and as a Laboratory Director at the Waksman Institute of Microbiology in 1987.[1] He was co-appointed as an Investigator of the Howard Hughes Medical Institute from 1997 to 2013.[1]

Ebright has performed research on protein-DNA interaction,[3][4][5] transcription initiation,[6][7][8][9][10][11][12] transcription activation,[13][14][15][16][17][18] transcription-translation coupling,[19] and antibacterial drug discovery.[20][21][22][23][24][25] Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,[3] the determination of the three-dimensional structural organization of the transcription initiation complex;[6][7][10][11] the demonstration that transcription start-site selection and initial transcription involve a "DNA scrunching" mechanism;[8][9][12] the demonstration that transcription activation can proceed by a "recruitment" mechanism;[13][14][15][17][18] the demonstration that bacterial transcription-translation coupling involves direct physical bridging of RNA polymerase and a ribosome by NusA and NusG[19]; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.[20][21][22][23][24][25]

In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.[26] In 1995 he received the Academic Press Walter J. Johnson Prize.[27] In 2013 he received a National Institutes of Health MERIT Award.[28] He was elected as a Fellow of the American Academy of Microbiology in 1996,[29] the American Association for the Advancement of Science in 2004,[30] the Infectious Diseases Society of America in 2011,[31] and the American Academy of Arts and Sciences in 2016.[32]

Ebright has opposed the proliferation of laboratories working on biological weapons agents[33] and has supported the strengthening of biosafety and biosecurity measures to reduce risks of release of biological weapons.[34]

References

  1. ^ a b c d e "Dr. Richard H. Ebright". Waksman Institute, Rutgers University. Retrieved October 6, 2011.
  2. ^ a b "Ebright, Richard H." Department of Chemistry, Rutgers University. Retrieved August 21, 2020.
  3. ^ a b Ebright, R. H.; Cossart, P.; Gicquel-Sanzey, B.; Beckwith, J. (1984). "Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli". Nature. 311 (5983): 232–235. doi:10.1038/311232a0. PMID 6090927.
  4. ^ Blatter, E.; Ebright, Y.; Ebright, R. H. (1992). "Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking". Nature. 359: 650–2. doi:10.1038/359650a0. PMID 1406998.
  5. ^ Pendergrast, P. S.; Ebright, Y.; Ebright, R. H. (1994). "High-specificity DNA cleavage agent: design and application to kilobase and megabase DNA substrates". Science. 265: 959–62. doi:10.1126/science.8052855. PMID 8052855.
  6. ^ a b Naryshkin, N.; Revyakin, A.; Kim, Y.; Mekler, V.; Ebright, R. H. (2000). "Structural organization of the RNA polymerase-promoter open complex". Cell. 101 (6): 601–611. doi:10.1016/S0092-8674(00)80872-7. PMID 10892647.
  7. ^ a b Mekler, V.; Kortkhonjia, E.; Mukhopadhyay, J.; Knight, J.; Revyakin, A.; Kapanidis, A.; Niu, W.; Ebright, Y.; Levy, R.; Ebright, R. H. (2002). "Structural organization of bacterial RNA polymerase holoenzyme and the RNA polymerase-promoter open complex". Cell. 108 (5): 599–614. doi:10.1016/S0092-8674(02)00667-0. PMID 11893332.
  8. ^ a b Kapanidis, A. N.; Margeat, E.; Ho, S. O.; Kortkhonjia, E.; Weiss, S.; Ebright, R. H. (2006). "Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism". Science. 314: 1144–1147. doi:10.1126/science.1131399. PMC 2754788. PMID 17110578.
  9. ^ a b Revyakin, A.; Liu, C.; Ebright, R. H.; Strick, T. (2006). "Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching". Science. 314 (5802): 1139–1143. Bibcode:2006Sci...314.1139R. doi:10.1126/science.1131398. PMC 2754787. PMID 17110577.
  10. ^ a b Chakraborty, A.; Wang, D.; Ebright, Y.; Korlann, Y.; Kortkhonjia, E.; Kim, T.; Chowdhury, S.; Wigneshweraraj, S.; Irschik, H.; Jansen, R.; Nixon, B.T.; Knight, J.; Weiss, S.; Ebright, R. H. (2012). "Opening and closing of the bacterial RNA polymerase clamp". Science. 337 (6094): 591–595. doi:10.1126/science.1218716. PMC 3626110. PMID 22859489.
  11. ^ a b Zhang, Y.; Feng, Y.; Chatterjee, S.; Tuske, S.; Ho, M. X.; Arnold, E.; Ebright, R. H. (2012). "Structural Basis of Transcription Initiation". Science. 338 (6110): 1076–80. doi:10.1126/science.1227786. PMC 3593053. PMID 23086998.
  12. ^ a b Winkelman, J.; Vvedenskaya, I.; Zhang, Y.; Bird, J.; Taylor, D.; Gourse, R.; Ebright, R.; Nickels, B. (2016). "Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection". Science. 351 (6277): 1090–1093. doi:10.1126/science.aad6881. PMC 4797950. PMID 26941320.
  13. ^ a b Heyduk, T.; Lee, J.; Ebright, Y.; Blatter, E.; Zhou, Y.; Ebright, R. H. (1993). "CAP interacts with RNA polymerase in solution in the absence of promoter DNA". Nature. 364 (6437): 548–549. doi:10.1038/364548a0. PMID 8393148.
  14. ^ a b Zhou, Y.; Busby, S.; Ebright, R. H. (1993). "Identification of the functional subunit of a dimeric transcription activator protein by use of "oriented heterodimers". Cell. 73 (2): 375–379. doi:10.1016/0092-8674(93)90236-J. PMID 8477449.
  15. ^ a b Chen, Y.; Ebright, Y.; Ebright, R. H. (1994). "Identification of the target of a transcription activator protein by protein-protein photocrosslinking". Science. 265 (5168): 90–92. doi:10.1126/science.8016656. PMID 8016656.
  16. ^ Niu, W.; Kim, Y.; Tau, G.; Heyduk, T.; Ebright, R. H. (1996). "Transcription activation at Class II CAP-dependent promoters: two interactions between CAP and RNA polymerase". Cell. 87 (6): 1123–1134. doi:10.1016/S0092-8674(00)81806-1. PMC 4430116. PMID 8978616.
  17. ^ a b Benoff, B.; Yang, H.; Lawson, C. L.; Parkinson, G.; Liu, J.; Blatter, E.; Ebright, Y. W.; Berman, H. M.; Arnold, E.; Ebright, R. H. (2002). "Structural basis of transcription activation: the CAP-alphaCTD-DNA complex". Science. 297 (5586): 1562–1566. Bibcode:2002Sci...297.1562B. doi:10.1126/science.1076376. PMID 12202833.
  18. ^ a b Feng, Y.; Zhang, Y.; Ebright, R. H. (2016). "Structural basis of transcription activation". Science. 352 (6291): 1330–1333. doi:10.1126/science.aaf4417. PMC 4905602. PMID 27284196.
  19. ^ a b Wang, C.; Molodtsov, V.; Firlar, E.; Kaelber, J.; Blaha, G.; Su, M.; Ebright, R. H. (2020). "Structural basis of transcription-translation coupling". Science. doi:10.1126/science.abb5317. PMID 32820061. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  20. ^ a b Mukhopadhyay, J.; Das, K.; Ismail, S.; Koppstein, D.; Jang, M.; Hudson, B.; Sarafianos, S.; Tuske, S.; Patel, J.; Jansen, R.; Irschik, H.; Arnold, E.; Ebright, R. H. (2008). "The RNA polymerase "switch region" is a target for inhibitors". Cell. 135 (2): 295–307. doi:10.1016/j.cell.2008.09.033. PMC 2580802. PMID 18957204. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  21. ^ a b Zhang, Y.; Degen, D.; Ho, M. X.; Sineva, E.; Ebright, K.; Ebright, Y. W.; Mekler, V.; Vahedian-Movahed, H.; Feng, Y.; Yin, R.; Tuske, S.; Irschik, H.; Jansen, R.; Maffioli, S.; Donadio, S.; Arnold, E.; Ebright, R. H. (2014). "GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides". eLife. 3: e02450. doi:10.7554/eLife.02450. PMC 3994528. PMID 24755292.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  22. ^ a b Degen, D.; Feng, Y.; Zhang, Y.; Ebright, K.; Ebright, Y.; Gigliotti, M.; Vahedian-Movahed, H.; Mandal, S.; Talaue, M.; Connell, N.; Arnold, E.; Fenical, W.; Ebright, R. (2014). "Transcription inhibition by the depsipeptide antibiotic salinamide A". eLife. 3: e02451. doi:10.7554/eLife.02451. PMC 4029172. PMID 24843001.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  23. ^ a b Lin, W.; Mandal, S.; Degen, D.; Liu, Y.; Ebright, Y. W.; Li. S.; Feng, Y.; Zhang, Y.; Mandal, S.; Jiang, Y.; Liu, S.; Gigliotti, M.; Talaue, M.; Connell, N.; Das, K.; Arnold, E.; Ebright, R. H. (2017). "Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition". Mol. Cell. 66: 169–179. doi:10.1016/j.molcel.2017.03.001. PMC 5438085. PMID 28392175. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  24. ^ a b Maffioli, S.; Zhang, Y.; Degen, D.; Carzaniga, T.; Del Gatto, G.; Serina, S.; Monciardini, P.; Mazzetti, C.; Guglierame, P.; Candiani, G.; Chiriac, A. I.; Facchetti, G.; Kaltofen, P.; Sahl, H.-G.; Dehò, G.; Donadio, S.; Ebright, R. H. (2017). "Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase". Cell. 169 (7): 1240–1248. doi:10.1016/j.cell.2017.05.042. PMC 5542026. PMID 28622509. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  25. ^ a b Lin, W.; Das, K.; Degen, D.; Mazumder, A.; Duchi, D.; Wang, D.; Ebright, Y.; Ebright, R.Y.; Sineva, E.; Gigliotti, M.; Srivastava, A.; Mandal, S.; Jiang, Y.; Liu, Y.; Yin, R.; Zhang, Z.; Eng, E.; Thomas, D.; Donadio, S.; Zhang, H.; Zhang, C.; Kapanidis, A.; Ebright, R. H. (2018). "Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)". Mol. Cell. 70 (1): 60–71. doi:10.1016/j.molcel.2018.02.026. PMC 6205224. PMID 29606590. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  26. ^ "ASBMB/Schering-Plough Research Institute Award". Retrieved October 8, 2011.
  27. ^ "The Walter J. Johnson Prize, 1995". Journal of Molecular Biology. 251 (3): 329. 1995. PMID 7650734.
  28. ^ "Gifts & Grants". Rutgers University Faculty and Staff Bulletin. June 12, 2013. Retrieved June 12, 2013.
  29. ^ "American Academy of Microbiology Fellowship Directory". Archived from the original on August 7, 2011. Retrieved October 8, 2011.
  30. ^ "AAAS Council Honors 308 Members for Their Contributions to Science" (Press release). AAAS. November 1, 2004. Retrieved October 8, 2011.
  31. ^ "Congratulations, New IDSA Fellows!". IDSA News. July–August 2011. Retrieved October 8, 2011.
  32. ^ "American Academy of Arts and Sciences Elects 213 National and International Scholars, Artists, Philanthropists, and Business and Civic Leaders" (Press release). American Academy of Arts and Sciences. April 20, 2016. Retrieved April 20, 2016.
  33. ^ Connell, N.; Ebright, R. H. (2002). "Bioweapon agents: more access means more risk". Nature. 415 (6870): 364. Bibcode:2002Natur.415..364E. doi:10.1038/415364b. PMID 11807521.
  34. ^ Ebright, R. H. (2012). "Mitigate the risks of release". Nature. 481: 257–259. doi:10.1038/481257a. PMC 7095491. PMID 22246325.
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