Montelukast: Difference between revisions
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==External links== |
==External links== |
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*[http://www.singulair.com Singulair Official Website] |
*[http://www.singulair.com Singulair Official Website] |
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*[http://merck-information.com/html/singulair.html Singulair Information, Side Effects and News] |
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*[http://www.duchs.com/information/Singulair Singulair Fact Sheet] |
*[http://www.duchs.com/information/Singulair Singulair Fact Sheet] |
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Revision as of 06:35, 17 October 2006
| File:Singulair.png | |
| Clinical data | |
|---|---|
| Pregnancy category | |
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 99% |
| Metabolism | Hepatic (CYP3A4 and CYP2C9-mediated) |
| Elimination half-life | 2.7-5.5 hours |
| Excretion | Biliary |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.115.927 |
| Chemical and physical data | |
| Formula | C35H36ClNO3S |
| Molar mass | 586.184 g/mol g·mol−1 |
Montelukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is not useful for the treatment of acute asthma attacks, so patients should also be supplied with rescue medication, such as an albuterol inhaler. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1, thus inhibiting bronchoconstriction.
Side effects
Side effects include GI disturbances, hypersensitivity reactions, sleep disorders and increased bleeding tendency, aside from many other generic adverse reactions.
Montelukast is marketed by Merck & Co. with the brand name Singulair®. It is available as oral tablets, chewable tablets, and oral granules.
External links
 | This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.