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Revision as of 07:56, 31 August 2011

Barakol
Clinical data
ATC code
  • none
Identifiers
  • 2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H12O4
Molar mass232.231 g/mol g·mol−1
3D model (JSmol)
  • CC2=Cc3cc(O)cc(c13)OC(C)=CC1(O)O2
  (verify)

Barakol is a compound found in the plant Senna siamea,[1] which is used in traditional herbal medicine. It has sedative and anxiolytic effects,[2][3] but use for these purposes is now discouraged due to hepatotoxicity.[4]

References

  1. ^ Padumanonda T, Gritsanapan W (2006). "Barakol contents in fresh and cooked Senna siamea leaves". The Southeast Asian Journal of Tropical Medicine and Public Health. 37 (2): 388–93. PMID 17125004. {{cite journal}}: Unknown parameter |month= ignored (help)
  2. ^ Thongsaard W, Pongsakorn S, Sudsuang R, Bennett GW, Kendall DA, Marsden CA (1997). "Barakol, a natural anxiolytic, inhibits striatal dopamine release but off uptake in vitro". European Journal of Pharmacology. 319 (2–3): 157–64. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Sukma M, Chaichantipyuth C, Murakami Y, Tohda M, Matsumoto K, Watanabe H (2002). "CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk". Journal of Ethnopharmacology. 83 (1–2): 87–94. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ Hongsirinirachorn M, Threeprasertsuk S, Chutaputti A (2003). "Acute hepatitis associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet. 86 Suppl 2: S484–9. PMID 12930029. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)