View source for S cell

{{for|the cell cycle phase|S phase}}
{{Infobox cell
| Name        = S cell
| Latin       = endocrinocytus S
| Image       =
| Caption     =
| Image2      =
| Caption2    =
| Precursor   =
| System      =
| Location = [[Jejunum]] and [[duodenum]]
| Function = [[Secretin]] secretion
}}
'''S cells''' are cells which release [[secretin]], found in the [[jejunum]] and [[duodenum]].<ref>{{Cite journal |last=Afroze |first=Syeda |last2=Meng |first2=Fanyin |last3=Jensen |first3=Kendal |last4=McDaniel |first4=Kelly |last5=Rahal |first5=Kinan |last6=Onori |first6=Paolo |last7=Gaudio |first7=Eugenio |last8=Alpini |first8=Gianfranco |last9=Glaser |first9=Shannon S. |date=October 2013 |title=The physiological roles of secretin and its receptor |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200670/ |journal=Annals of Translational Medicine |volume=1 |issue=3 |pages=29 |doi=10.3978/j.issn.2305-5839.2012.12.01 |issn=2305-5839 |pmc=4200670 |pmid=25332973}}</ref> They are stimulated by a drop in [[pH]] to 4 or below in the [[small intestine]]'s lumen. The released secretin will increase the secretion of [[bicarbonate]] (HCO<sub>3</sub><sup>−</sup>) into the lumen, via the [[pancreas]]. This is primarily accomplished by an increase in [[cyclic AMP]] that activates [[Cystic fibrosis transmembrane conductance regulator|CFTR]] to release chloride anions into the lumen. The luminal Cl<sup>−</sup> is then involved in a [[bicarbonate transporter protein]] exchange, in which the chloride is reabsorbed by the cell and HCO<sub>3</sub><sup>−</sup> is secreted into the [[lumen (anatomy)|lumen]]. S cells are also one of the main producers of [[cyclosamatin]].


==References==
{{reflist}}

{{Gastrointestinal physiology}}
{{Authority control}}

{{DEFAULTSORT:S Cell}}
[[Category:Human cells]]
[[Category:Digestive system]]


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