Talk:Demeclocycline

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Demeclocycline is NOT semisynthetic

Latest comment: 6 years ago1 comment1 person in discussion

According to Elks et al.^[1] and Chopra et al.^[2] Demeclocycline is NOT a semisynthetic drug. Instead it is produced naturally by a genetically modified strain of Streptomyces. The author of the cited review, I. Chopra, used to work for one of the leading manufacturers of this compound, even more as a specialist for tetracyclines, who published many more papers on this topic. He must have known this. Same is also supported by the DailyMed entry.^[3] (I updated the existing link.) J. M. Hall,^[4] however who just made a short lexicon entry, most likely mistook her statement form the fact that the drug is used for producing semisynthetic derivatives like Minocycline and Doxycycline. The entry in Dorland's Medical Dictionary^[5] is not available anymore. Thus, I took off the latter two references, which obviously are misleading and simply removed the statement that Demeclocycline is semisynthetic.--Asigler (talk) 22:20, 11 October 2018 (UTC)Reply

References

^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 356–. ISBN 978-1-4757-2085-3.
^ Chopra, I.; Hawkey, P. M.; Hinton, M. (1992). "Tetracyclines, molecular and clinical aspects". J. Antimicrob. Chemother. 29 (3): 245–277. doi:10.1093/jac/29.3.245.
^ DailyMed. "Demeclocycline Hydrochloride - demeclocycline tablet". Drug label information. Retrieved 2008-12-20.
^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 92–. ISBN 978-94-011-4439-1.
^ "demeclocycline" at Dorland's Medical Dictionary

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[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 356–. ISBN 978-1-4757-2085-3.

[Chopra-2] Chopra, I.; Hawkey, P. M.; Hinton, M. (1992). "Tetracyclines, molecular and clinical aspects". J. Antimicrob. Chemother. 29 (3): 245–277. doi:10.1093/jac/29.3.245.

[DailyMed-3] DailyMed. "Demeclocycline Hydrochloride - demeclocycline tablet". Drug label information. Retrieved 2008-12-20.

[MortonHall2012-4] I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 92–. ISBN 978-94-011-4439-1.

[5] "demeclocycline" at Dorland's Medical Dictionary

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