Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.[5]

TFAP4
Identifiers
AliasesTFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4), transcription factor AP-4
External IDsOMIM: 600743; MGI: 103239; HomoloGene: 2424; GeneCards: TFAP4; OMA:TFAP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003223

NM_031182

RefSeq (protein)

NP_003214

NP_112459

Location (UCSC)Chr 16: 4.26 – 4.27 MbChr 16: 4.36 – 4.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090447Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005718Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.