TFAP4

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

TFAP4
Identifiers
Aliases	TFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4), transcription factor AP-4
External IDs	OMIM: 600743; MGI: 103239; HomoloGene: 2424; GeneCards: TFAP4; OMA:TFAP4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 4,257,186 bp End 4,273,075 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 A1|16 2.45 cM Start 4,362,525 bp End 4,377,718 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb beta cell vena cava sural nerve ganglionic eminence cerebellar hemisphere lateral nuclear group of thalamus subthalamic nucleus nasal epithelium right hemisphere of cerebellum Top expressed in tail of embryo genital tubercle ventricular zone yolk sac epiblast female urethra muscle of thigh lip zygote embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity protein dimerization activity transcription coactivator activity histone deacetylase binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA binding E-box binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component transcription repressor complex nucleus mitochondrion Biological process negative regulation of cell population proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity transcription, DNA-templated negative regulation of gene expression DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cellular response to dexamethasone stimulus negative regulation of DNA binding positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of apoptotic process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of transcription, DNA-templated regulation of mitotic cell cycle phase transition protein-containing complex assembly regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7023 83383 Ensembl ENSG00000090447 ENSMUSG00000005718 UniProt Q01664 Q9JIZ5 RefSeq (mRNA) NM_003223 NM_031182 RefSeq (protein) NP_003214 NP_112459 Location (UCSC) Chr 16: 4.26 – 4.27 Mb Chr 16: 4.36 – 4.38 Mb PubMed search
Wikidata
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Function

Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.

Further reading

• Hu YF, Lüscher B, Admon A, et al. (1991). "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity". Genes Dev. 4 (10): 1741–52. doi:10.1101/gad.4.10.1741. PMID 2123466.
• Mermod N, Williams TJ, Tjian R (1988). "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro". Nature. 332 (6164): 557–61. Bibcode:1988Natur.332..557M. doi:10.1038/332557a0. PMID 2833704. S2CID 4340282.
• Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. doi:10.1128/JVI.68.11.7188-7199.1994. PMC 237158. PMID 7933101.
• Lewis TB, Wood S, Michaelis EK, et al. (1996). "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24". Genomics. 32 (1): 131–3. doi:10.1006/geno.1996.0088. PMID 8786101.
• Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene". Mol. Endocrinol. 12 (2): 233–47. doi:10.1210/mend.12.2.0057. PMID 9482665.
• King-Jones K, Korge G, Lehmann M (1999). "The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4". J. Mol. Biol. 291 (1): 71–82. doi:10.1006/jmbi.1999.2963. PMID 10438607.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553. S2CID 4362044.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• TFAP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.