SEC24B

Protein transport protein Sec24B is a protein that in humans is encoded by the SEC24B gene.

SEC24B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3EH1
Identifiers
Aliases	SEC24B, SEC24, SEC24 homolog B, COPII coat complex component
External IDs	OMIM: 607184; MGI: 2139764; HomoloGene: 55968; GeneCards: SEC24B; OMA:SEC24B - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q25 Start 109,433,772 bp End 109,540,896 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G3 Start 129,776,408 bp End 129,855,202 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue skin of hip skin of thigh retinal pigment epithelium biceps brachii Skeletal muscle tissue of biceps brachii jejunal mucosa germinal epithelium mucosa of sigmoid colon Epithelium of choroid plexus Top expressed in genital tubercle tail of embryo granulocyte ventricular zone neural layer of retina lip saccule dentate gyrus of hippocampal formation granule cell superior frontal gyrus muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding zinc ion binding metal ion binding Cellular component cytoplasm endoplasmic reticulum membrane Golgi membrane endoplasmic reticulum membrane COPII vesicle coat cytosol ER to Golgi transport vesicle membrane cytoplasmic vesicle COPII-coated ER to Golgi transport vesicle Biological process lung morphogenesis antigen processing and presentation of exogenous peptide antigen via MHC class II pulmonary artery morphogenesis antigen processing and presentation of peptide antigen via MHC class I regulation of establishment of planar polarity involved in neural tube closure coronary artery morphogenesis outflow tract morphogenesis auditory receptor cell morphogenesis aorta morphogenesis auditory receptor cell stereocilium organization neural tube closure COPII vesicle coating protein transport intracellular protein transport regulation of cargo loading into COPII-coated vesicle lung lobe morphogenesis cochlear nucleus development endoplasmic reticulum to Golgi vesicle-mediated transport vesicle-mediated transport COPII-coated vesicle cargo loading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10427 99683 Ensembl ENSG00000138802 ENSMUSG00000001052 UniProt O95487 n/a RefSeq (mRNA) NM_001042734 NM_001300813 NM_006323 NM_001318085 NM_001318086 NM_207209 RefSeq (protein) NP_001036199 NP_001287742 NP_001305014 NP_001305015 NP_006314 n/a Location (UCSC) Chr 4: 109.43 – 109.54 Mb Chr 3: 129.78 – 129.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Mancias JD, Goldberg J (2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope". Mol. Cell. 26 (3): 403–14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.