Poliovirus receptor-related 2

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Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.

NECTIN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3R0N, 4DFH, 4DFI, 4HZA
Identifiers
Aliases	NECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDs	OMIM: 600798; MGI: 97822; HomoloGene: 86092; GeneCards: NECTIN2; OMA:NECTIN2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 44,846,175 bp End 44,889,223 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 9.94 cM Start 19,450,569 bp End 19,484,408 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium olfactory zone of nasal mucosa apex of heart right lobe of liver gallbladder right testis left adrenal cortex body of stomach mucosa of transverse colon upper lobe of left lung Top expressed in yolk sac transitional epithelium of urinary bladder Ileal epithelium decidua gastrula lumbar spinal ganglion endothelial cell of lymphatic vessel duodenum epiblast crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function coreceptor activity virus receptor activity protein binding identical protein binding signaling receptor binding cell adhesion molecule binding protein heterodimerization activity protein homodimerization activity Cellular component integral component of membrane membrane cell-cell junction focal adhesion plasma membrane integral component of plasma membrane cell surface zonula adherens extracellular exosome apical junction complex cell-cell contact zone Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules sperm mitochondrion organization cell recognition positive regulation of immunoglobulin mediated immune response regulation of viral entry into host cell susceptibility to natural killer cell mediated cytotoxicity positive regulation of mast cell activation cell adhesion acrosome assembly cytoskeleton organization positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target cilium organization establishment of mitochondrion localization spermatid development regulation of immune response fertilization spermatid nucleus differentiation susceptibility to T cell mediated cytotoxicity viral process cell part morphogenesis adherens junction organization positive regulation of natural killer cell mediated cytotoxicity homophilic cell adhesion via plasma membrane adhesion molecules viral entry into host cell signal transduction positive regulation of T cell receptor signaling pathway virion attachment to host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5819 19294 Ensembl ENSG00000130202 ENSMUSG00000062300 UniProt Q92692 P32507 RefSeq (mRNA) NM_001042724 NM_002856 NM_001159724 NM_008990 RefSeq (protein) NP_001036189 NP_002847 NP_001153196 NP_033016 Location (UCSC) Chr 19: 44.85 – 44.89 Mb Chr 7: 19.45 – 19.48 Mb PubMed search
Wikidata
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Function

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

See also

• Cluster of differentiation

Further reading

• Eberlé F, Dubreuil P, Mattei MG, et al. (1995). "The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene". Gene. 159 (2): 267–72. doi:10.1016/0378-1119(95)00180-E. PMID 7622062.
• Warner MS, Geraghty RJ, Martinez WM, et al. (1998). "A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus". Virology. 246 (1): 179–89. doi:10.1006/viro.1998.9218. PMID 9657005.
• Freistadt MS, Eberle KE (1998). "Physical association between CD155 and CD44 in human monocytes". Mol. Immunol. 34 (18): 1247–57. doi:10.1016/S0161-5890(98)00003-0. PMID 9683266.
• Lopez M, Aoubala M, Jordier F, et al. (1999). "The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule". Blood. 92 (12): 4602–11. doi:10.1182/blood.V92.12.4602. PMID 9845526.
• Shukla D, Rowe CL, Dong Y, et al. (1999). "The Murine Homolog (Mph) of Human Herpesvirus Entry Protein B (HveB) Mediates Entry of Pseudorabies Virus but Not Herpes Simplex Virus Types 1 and 2". J. Virol. 73 (5): 4493–7. doi:10.1128/JVI.73.5.4493-4497.1999. PMC 104343. PMID 10196354.
• Takahashi K, Nakanishi H, Miyahara M, et al. (1999). "Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein". J. Cell Biol. 145 (3): 539–49. doi:10.1083/jcb.145.3.539. PMC 2185068. PMID 10225955.
• Freitas EM, Zhang WJ, Lalonde JP, et al. (1999). "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1". DNA Seq. 9 (2): 89–100. doi:10.3109/10425179809086433. PMID 10520737.
• Lopez M, Cocchi F, Menotti L, et al. (2000). "Nectin2α (PRR2α or HveB) and Nectin2δ Are Low-Efficiency Mediators for Entry of Herpes Simplex Virus Mutants Carrying the Leu25Pro Substitution in Glycoprotein D". J. Virol. 74 (3): 1267–74. doi:10.1128/JVI.74.3.1267-1274.2000. PMC 111461. PMID 10627537.
• Cocchi F, Menotti L, Dubreuil P, et al. (2000). "Cell-to-Cell Spread of Wild-Type Herpes Simplex Virus Type 1, but Not of Syncytial Strains, Is Mediated by the Immunoglobulin-Like Receptors That Mediate Virion Entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB)". J. Virol. 74 (8): 3909–17. doi:10.1128/JVI.74.8.3909-3917.2000. PMC 111902. PMID 10729168.
• Bouchard MJ, Dong Y, McDermott BM, et al. (2000). "Defects in Nuclear and Cytoskeletal Morphology and Mitochondrial Localization in Spermatozoa of Mice Lacking Nectin-2, a Component of Cell-Cell Adherens Junctions". Mol. Cell. Biol. 20 (8): 2865–73. doi:10.1128/MCB.20.8.2865-2873.2000. PMC 85510. PMID 10733589.
• Martinez WM, Spear PG (2001). "Structural Features of Nectin-2 (HveB) Required for Herpes Simplex Virus Entry". J. Virol. 75 (22): 11185–95. doi:10.1128/JVI.75.22.11185-11195.2001. PMC 114698. PMID 11602758.
• Freitas EM, Phan TC, Herbison CE, et al. (2002). "The poliovirus receptor related 2 (PRR2) and apolipoprotein E genes and coronary heart disease". Journal of Cardiovascular Risk. 9 (1): 59–65. doi:10.1097/00043798-200202000-00009. PMID 11984219.
• Fabre S, Reymond N, Cocchi F, et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.
• Struyf F, Martinez WM, Spear PG (2002). "Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions". J. Virol. 76 (24): 12940–50. doi:10.1128/JVI.76.24.12940-12950.2002. PMC 136698. PMID 12438620.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bottino C, Castriconi R, Pende D, et al. (2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.
• Zago A, Spear PG (2003). "Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells". J. Virol. 77 (17): 9695–9. doi:10.1128/JVI.77.17.9695-9699.2003. PMC 187405. PMID 12915581.
• Tahara-Hanaoka S, Shibuya K, Onoda Y, et al. (2005). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. doi:10.1093/intimm/dxh059. hdl:2241/102014. PMID 15039383.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Rosche B, Cepok S, Stei S, et al. (2004). "The role of the polio virus receptor and the herpesvirus entry mediator B genes for the development of MS". J. Neuroimmunol. 156 (1–2): 171–7. doi:10.1016/j.jneuroim.2004.07.001. PMID 15465608. S2CID 39448365.

External links

• PVRL2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q92692 (Human Nectin-2) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P32507 (Mouse Nectin-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.