HES6

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.

HES6
Identifiers
Aliases	HES6, C-HAIRY1, HES-6, bHLHb41, bHLHc23, hes family bHLH transcription factor 6
External IDs	OMIM: 610331; MGI: 1859852; HomoloGene: 23111; GeneCards: HES6; OMA:HES6 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 238,238,267 bp End 238,240,662 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 91,339,205 bp End 91,341,760 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone secondary oocyte C1 segment mucosa of transverse colon anterior pituitary Brodmann area 9 primary visual cortex cingulate gyrus anterior cingulate cortex Top expressed in ventricular zone fossa right kidney internal carotid artery adrenal gland saccule ganglionic eminence left lobe of liver Paneth cell proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein dimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription coregulator activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component nucleus transcription regulator complex Biological process regulation of transcription by RNA polymerase II multicellular organism development cell differentiation negative regulation of transcription by RNA polymerase II transcription, DNA-templated nervous system development regulation of transcription, DNA-templated somitogenesis Notch signaling pathway regulation of neurogenesis anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55502 55927 Ensembl ENSG00000144485 ENSMUSG00000067071 UniProt Q96HZ4 Q9JHE6 RefSeq (mRNA) NM_018645 NM_001142853 NM_001282434 NM_019479 NM_001360899 NM_001360900 RefSeq (protein) NP_001136325 NP_001269363 NP_061115 NP_062352 NP_001347828 NP_001347829 Location (UCSC) Chr 2: 238.24 – 238.24 Mb Chr 1: 91.34 – 91.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HES6 has been shown to interact with TLE1.

Further reading

• Bech P, Bolwig TG, Dein E, Jacobsen O, Gram LF (1975). "Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale". Acta Psychiatr Scand. 52 (1): 1–6. doi:10.1111/j.1600-0447.1975.tb00017.x. PMID 1155198. S2CID 7793095.
• Vasiliauskas D, Stern CD (2000). "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors". Mech. Dev. 98 (1–2): 133–7. doi:10.1016/S0925-4773(00)00443-3. PMID 11044617. S2CID 15528953.
• Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.
• Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array". Cancer Lett. 198 (2): 229–39. doi:10.1016/S0304-3835(03)00313-6. PMID 12957362.
• Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMC 193938. PMID 12972610.
• Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation". Biochem. Biophys. Res. Commun. 332 (1): 33–6. doi:10.1016/j.bbrc.2005.04.089. PMID 15896295.
• Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F (2007). "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion". Biochem. Biophys. Res. Commun. 355 (2): 331–7. doi:10.1016/j.bbrc.2007.01.153. PMC 1852427. PMID 17300753.
• Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle". J. Gerontol. A Biol. Sci. Med. Sci. 62 (1): 9–17. CiteSeerX 10.1.1.499.7911. doi:10.1093/gerona/62.1.9. PMID 17301032.
• Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells". FEBS Lett. 581 (24): 4651–6. Bibcode:2007FEBSL.581.4651S. doi:10.1016/j.febslet.2007.08.059. PMID 17826772. S2CID 13986512.

External links

• HES6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.