Talk:Troponin

Untitled

The following reference was inserted:

Rottbauer W, Greten T, Müller-Bardoff M, Remppis A, Zehelein J, Grünig E, Katus HA. Troponin T: a diagnostic marker for myocardial infarction and minor cardiac cell damage. Eur Heart J 1996;17:3-8.

It looks useful, but no part of the article presently refers to it. JFW | T@lk 10:44, 31 July 2006 (UTC)

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Ml17k.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 11:45, 17 January 2022 (UTC)

Image

The new image looks somewhat amateuristic, IMHO. Anyone able to redraw it? JFW | T@lk 20:53, 17 January 2007 (UTC)

It's also fairly flawed because it implies that binding of four calcium ions is significant, when actually just one or two are regulatory, in cardiac or skeletal muscle, respectively. There is a lot of debate about the other two calciums, and they could well be replaced by magenesium in various biochemical contexts. I can redraw it, or we can perhaps duplicate an image from one of the open access journals. rmbh 02:45, 18 May 2007 (UTC)

Redrawn. Quite simplified but now much more useful, and doesn't imply (as the previous one did) that 4 Ca2+ bind in a regulatory fashion. rmbh (talk) 00:23, 1 January 2011 (UTC)

Troponin subunits

I suggest merging the 3 subunits and their descriptions into this article as a subtopic. Each article for the subunits are very short and would better contribute in this multimer complex article. Only when their descriptions are significant should they have their own link. LostLucidity (talk) 16:37, 28 January 2008 (UTC)

Troponin complex

I suggest merging with Troponin complex arcicle, while keeping Troponin test article separate. --Kender (talk) 19:35, 20 April 2010 (UTC)

Definitely keep troponin test separate from troponin. the test is itself a huge deal, very different from the biology of troponins. -Immunology2 —Preceding unsigned comment added by 171.67.129.16 (talk) 05:12, 1 May 2011 (UTC)

Heart contractile function

I've added this because I read a small article about this and didn't see it here - might be relevant for someone, someday. If anyone can extend this section, please do. — Preceding unsigned comment added by RonaldKunenborg (talk • contribs) 20:37, 21 February 2011 (UTC)

Pronunciation guide

I tried to add a pronunciation guide & its url after "Troponin is" but it created a big gap in the text. I hope an editor can add it:

http://dictionary.reference.com/browse/troponin pronounced TROH-puh-nin 24.0.113.90 (talk) 12:30, 9 May 2012 (UTC)

Likely disruption of tronopin T gene in obese humans & movement disorder

I hope an editor can integrate this info into the article bc it's highly relevant to the obesity epidemic and how lifestyle changes can affect gene function and therefore profoundly affect health:

http://well.blogs.nytimes.com/2011/05/18/the-body-weight-muscle-mismatch/ ' “It seems likely” that there are changes in troponin T activity in obese people’s muscles and that, as a result, “it really is physiologically hard for them to move,” [Dr Marden said.]' 24.0.113.90 (talk) 12:48, 9 May 2012 (UTC)

At first glance, this is too speculative. Rather than say that its "highly relevant", I'm going to hedge and suggest that it is "potentially relevant". What the press heralds as breakthroughs usually does not translate to major changes. I'll take a close look at it, but I'm not sure that there is much to be added to the article. In general, health science on Wikipedia is gathered from review articles in journals and medical texts rather than research papers and news reports. Thank you.Novangelis (talk) 19:42, 9 May 2012 (UTC)

Merge: troponin complex

I think troponin complex should be merged into this page. It covers the same subject. Arripay (talk) 22:59, 13 November 2013 (UTC)  Done

Incomplete sentence

I think the following sentence is incomplete: "In both primary pulmonary hypertension, pulmonary embolism, and acute exacerbations of chronic obstructive pulmonary disease (COPD), right ventricular strain with increased wall tension and ischemia". And in the next paragraph (about nervous system diseases) I suppose the troponin levels are increased but the article doesn't say anything.-Miguelferig (talk) 20:08, 17 October 2014 (UTC)

Interpretation

doi:10.1001/jama.2014.5554 is a JAMA review of the interpretation of acutely raised cardiac troponins. It would be a great source for the section about the diagnostic use of troponins. JFW | T@lk 17:31, 19 November 2014 (UTC)

Problem with WHO diagnostic criteria

I think there are problems in this sentence:

However, diagnostic criteria for raised troponin indicating myocardial infarction is currently set by the WHO at a threshold of 2 ug or higher.

Everything I see indicates that in the USA the standard units for troponin diagnostic tests are ng/mL (nanograms per milliliter). For troponin I, the following wording appears on an actual test result I have seen:

Troponin I > 0.04 ng/mL indicative of non-specific cardiac myonecrosis/ischemia.

The diagnosis of acute myocardial infarction requires serial troponin measurements (baseline and again in 2-3 hours) with at least one value above the 99% upper reference limit (99% of tested individuals have a troponin level < 0.04 ng/mL), combined with symptoms of ischemia, ECG changes, regional wall abnormalities, and history or risk factors for CAD.

Other sources also seem to indicate the reference level for troponin I is 0.04 ng/mL. A brief look at some references suggests that 0.01 ng/mL is the reference limit for Troponin T. In any case, the units "ug" (micrograms) don't make much sense, unless they are understood to be ug per liter. There is also the issue that the sentence refers to "raised troponin," without specifying which protein (T, I, or C). Finally, no reference is cited for this threshold as set by WHO. --Gpc62 (talk) 15:44, 16 April 2015 (UTC)