EPH receptor A5

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.

EPHA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R2P, 4ET7
Identifiers
Aliases	EPHA5, CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4, EPH receptor A5
External IDs	OMIM: 600004; MGI: 99654; HomoloGene: 55824; GeneCards: EPHA5; OMA:EPHA5 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.1-q13.2 Start 65,319,563 bp End 65,670,495 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 E1|5 43.0 cM Start 84,202,620 bp End 84,565,241 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone sperm prefrontal cortex middle temporal gyrus testicle entorhinal cortex dorsolateral prefrontal cortex primary visual cortex frontal pole Top expressed in ganglionic eminence ventral tegmental area ventricular zone Region I of hippocampus proper substantia nigra barrel cortex olfactory bulb piriform cortex amygdala hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane rough endoplasmic reticulum cell projection membrane plasma membrane integral component of plasma membrane axon soma dendrite perinuclear region of cytoplasm external side of plasma membrane cytoplasm neuron projection receptor complex Biological process regulation of insulin secretion involved in cellular response to glucose stimulus regulation of actin cytoskeleton organization phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway regulation of GTPase activity neuron development nervous system development protein phosphorylation positive regulation of CREB transcription factor activity peptidyl-tyrosine phosphorylation hippocampus development cAMP-mediated signaling axon guidance ephrin receptor signaling pathway negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2044 13839 Ensembl ENSG00000145242 ENSMUSG00000029245 UniProt P54756 Q60629 RefSeq (mRNA) NM_001281765 NM_001281766 NM_001281767 NM_004439 NM_182472 NM_001318761 NM_007937 RefSeq (protein) NP_001268694 NP_001268695 NP_001268696 NP_001305690 NP_004430 NP_872272 NP_031963 NP_001389678 NP_001389679 NP_001389680 NP_001389681 NP_001389682 NP_001389683 NP_001389684 NP_001389685 NP_001389686 NP_001389687 NP_001389688 NP_001389689 NP_001389690 Location (UCSC) Chr 4: 65.32 – 65.67 Mb Chr 5: 84.2 – 84.57 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Further reading

• Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands". Cell Tissue Res. 290 (2): 251–9. doi:10.1007/s004410050929. PMID 9321686. S2CID 1506266.
• Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1". Cell Tissue Res. 290 (2): 261–4. doi:10.1007/s004410050930. PMID 9321687. S2CID 39695853.
• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
• Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene. 10 (5): 897–905. PMID 7898931.
• Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9. Bibcode:1994Sci...266..816D. doi:10.1126/science.7973638. PMID 7973638.
• Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
• Miescher GC, Taylor V, Olivieri G, et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors". Brain Res. Mol. Brain Res. 46 (1–2): 17–24. doi:10.1016/S0169-328X(96)00268-9. PMID 9191074.
• Stein E, Savaskan NE, Ninnemann O, et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting". J. Neurosci. 19 (20): 8885–93. doi:10.1523/JNEUROSCI.19-20-08885.1999. PMC 6782767. PMID 10516308.