The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Trachyspic Acid, a New Metabolite Produced by Talaromyces trachyspermus, that Inhibits Tumor Cell Heparanase: Taxonomy of the Producing Strain, Fermentation, Isolation, Structural Elucidation, and Biological Activity
HIDEYUKI SHIOZAWA, MASAAKI TAKAHASHI, TOSHIO TAKATSU, TAKESHI KINOSHITA, KAZUHIKO TANZAWA, TSUYOSHI HOSOYA, KOUHEI FURUYA, SHUJI TAKAHASHI, KAZUO FURIHATA, HARUO SETO
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1995 Volume 48 Issue 5 Pages 357-362

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Abstract
Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC50 value of trachyspic acid against heparanase was 36 μM.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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