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Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review
- Sandra Bivegete1,2 , Anna L McNaughton1 , Adam Trickey1 , Zak Thornton1 , Becky Scanlan1 , Aaron G Lim1,2 , Lina Nerlander3 , Hannah Fraser1,2 , Josephine G Walker1 , Matthew Hickman1,2 , Peter Vickerman1,2 , Helen Johnson3 , Erika Duffell3 , Ellen Brooks-Pollock1,2 , Hannah Christensen1,2
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View Affiliations Hide AffiliationsAffiliations: 1 Population Health Sciences, Bristol Medical School, University of Bristol, United Kingdom 2 Health Protection Research Unit (HPRU) in Behavioural Science and Evaluation, Bristol, United Kingdom 3 European Centre for Disease Prevention and Control (ECDC), Stockholm, SwedenSandra BivegeteSandra.Bivegete bristol.ac.uk
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Citation style for this article: Bivegete Sandra, McNaughton Anna L, Trickey Adam, Thornton Zak, Scanlan Becky, Lim Aaron G, Nerlander Lina, Fraser Hannah, Walker Josephine G, Hickman Matthew, Vickerman Peter, Johnson Helen, Duffell Erika, Brooks-Pollock Ellen, Christensen Hannah. Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review. Euro Surveill. 2023;28(30):pii=2200738. https://doi.org/10.2807/1560-7917.ES.2023.28.30.2200738 Received: 09 Sept 2022; Accepted: 29 Mar 2023
Abstract
The burden of chronic hepatitis B virus (HBV) varies across the European Union (EU) and European Economic Area (EEA).
We aimed to update the 2017 HBV prevalence estimates in EU/EEA countries and the United Kingdom for 2018 to 2021.
We undertook a systematic review, adding to HBV prevalence estimates from an existing (2005–2017) database. Databases were searched for original English-language research articles including HBV surface antigen prevalence estimates among the general population, pregnant women, first-time blood donors (FTB), men who have sex with men (MSM), migrants and people in prison. Country experts contributed grey literature data. Risk of bias was assessed using a quality assessment framework.
The update provided 147 new prevalence estimates across the region (updated total n = 579). Median HBV prevalence in the general population was 0.5% and the highest was 3.8% (Greece). Among FTB, the highest prevalence was 0.8% (Lithuania). Estimates among pregnant women were highest in Romania and Italy (5.1%). Among migrants, the highest estimate was 31.7% (Spain). Relative to 2017 estimates, median prevalence among pregnant women decreased by 0.5% (to 0.3%) and increased by 0.9% (to 5.8%) among migrants. Among MSM, the highest estimate was 3.4% (Croatia). Prevalence among people in prison was highest in Greece (8.3%) and the median prevalence increased by 0.6% (to 2.1%).
The HBV prevalence is low in the general population and confined to risk populations in most European countries with some exceptions. Screening and treatment should be targeted to people in prison and migrants.
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