Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions
Fig 6
Illustration of the range of influences of network structure and contents on mtDNA statistics from partitioning.
MtDNA molecules distributed randomly through the cytoplasm are segregated binomially (centre); the influence of network structure (heterogeneous or homogeneous distributions) and mtDNA inclusion (genetically neutral or biased) changes cell-to-cell variability in different ways: Depending upon genetic bias and network heterogeneity, networks can both increase and decrease cell-to-cell mtDNA variability in copy number and heteroplasmy. Genetic bias for network inclusion can modulate (physical) copy number statistics, by influencing the total number of mtDNA molecules that are evenly spread through the cell.
doi: https://doi.org/10.1371/journal.pcbi.1010953.g006