Through contact algebras we study theories of mereotopology in a uniform way that clearly separates mereological from topological concepts. We identify and axiomatize an important subclass of closure mereotopologies (CMT) called unique closure mereotopologies (UCMTs) whose models always have orthocomplemented contact algebras (OCAs), an algebraic counterpart. The notion of MT-representability, a weak form of spatial representability but stronger than topological representability, suffices to prove that spatially representable complete OCAs are pseudocomplemented and satisfy the Stone identity. Within the resulting class of contact algebras the strength of the algebraic complementation delineates two classes of mereotopology according to the key ontological choice between mereological and topological closure operations. All closure operations are defined mereologically if and only if the corresponding contact algebras are uniquely complemented while topological closure operations highly restrict the contact relation but allow not uniquely complemented and nondistributive contact algebras. Each class contains a single ontologically coherent theory that admits discrete models.