skip to main content
10.1145/3674829.3675073acmconferencesArticle/Chapter ViewAbstractPublication PagescompassConference Proceedingsconference-collections
short-paper
Open access

Interpretable Checklist for Delirium Detection

Published: 28 August 2024 Publication History

Abstract

Delirium is a syndrome characterized by acute and fluctuating change in attention, awareness, and cognition. Common in older adults, especially those with underlying medical conditions, delirium is associated with higher mortality rates, longer hospital stays, and increased healthcare costs. Early identification and management of delirium therefore becomes essential in order to prevent adverse outcomes, improve patient health, and reduce healthcare costs. As multiple predisposing (e.g., neurological disorders) and precipitating factors (e.g., medications) can be involved in the aetiology of delirium, detecting the syndrome early on can be challenging. In this work, we present an interpretable multimodal checklist that can aid clinicians in delirium detection. Specifically, we leverage causal decision trees to extract most relevant features for delirium detection which are then used in learning the predictive checklist. Experiments demonstrate the efficacy of the approach over existing methods in terms of both detection accuracy and interpretability.

References

[1]
Mavrodaris A, Powell J, and Thorogood M.2013. Prevalences of dementia and cognitive impairment among older people in sub-saharan Africa: a systematic review.Bull World Health Organ. 91(10):773–83. (2013).
[2]
American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders. 10.1176/appi.books.9780890425596 (2013).
[3]
Susan Athey, Julie Tibshirani, and Stefan Wager. 2019. Generalized random forests. The Annals of Statistics 47.2 (2019).
[4]
Philip Bobko, Philip L Roth, and Maury A Buster. 2007. The usefulness of unit weights in creat- ing composite scores: A literature review, application to content validity, and meta-analysis. Organizational Research Methods (2007).
[5]
Ernest W Burgess. 1928. Factors determining success or failure on parole.The workings of the indeterminate sentence law and the parole system in Illinois (1928).
[6]
Hosker C and Ward D.2017. Hypoactive delirium. BMJ (2017).
[7]
Joaquim Cerejeira and Elizabeta B. Mukaetova-Ladinska. 2011. A Clinical Update on Delirium: From Early Recognition to Effective Management. Nurs. Res. Pract. (2011).
[8]
Mary Charlson. Retrieved June 2023. Charlson Comorbidity Index (CCI). https://www.mdcalc.com/calc/3917/charlson-comorbidity-index-cci (Retrieved June 2023).
[9]
Jacob Cohen. 1992. Things i have learned (so far).Annual Convention of the American Psychologi- cal Association, 98th, Aug, 1990, Boston, MA, US; Presented at the aforementioned conference. American Psychological Association (1992).
[10]
M. G. et al. Cole. 2015. Partial and no recovery from delirium in older hospitalized adults: frequency and baseline risk factors. J. Am. Geriatr. Soc. 63 (2015), 2340–2348.
[11]
Sanders R. D and Maze M. C. 2011. Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway.Can J Anaesth. 58(2) (2011), 149–156.
[12]
Anis Davoudi 2019. Role of Wearable Accelerometer Devices in Delirium Studies: A Systematic Review. Crit Care Explor. (2019).
[13]
Vasilevskis E. E, Han J. H, Hughes C. G, and Ely E.W. 2012. Epidemiology and risk factors for delirium across hospital settings. Best Pract Res Clin Anaesthesiol 3, 26 (2012). https://doi.org/10.1016/j.bpa.2012.07.003
[14]
EconML. Retrieved June 2023. EconML: A Python Package for ML-Based Heterogeneous Treatment Effects Estimation. https://pypi.org/project/econml/ (Retrieved June 2023).
[15]
Oh ES, Fong TG, Hshieh TT, and Inouye SK.2017. Delirium in older persons: advances in diagnosis and treatment.JAMA (2017).
[16]
Office for National Statistics. 2018. Living longer: how our population is changing and why it matters.Office for National Statistics (2018).
[17]
Roanna J Hall 2012. Delirium detection and monitoring outside the ICU. Best Practice and Research Clinical Anaesthesiology (2012).
[18]
Cerejeira J, Nogueira V, and et al. Luís P. 2012. The cholinergic system and inflammation: common pathways in delirium pathophysiology.J Am Geriatr Soc. 60(4) (2012), 669–675.
[19]
Qixuan Jin, Haoran Zhang, Thomas Hartvigsen, and Maryzeh Ghassemi. 2022. Treatment in Psychiatry: Delirium. NeurIPS workshop on Learning from Time Series for Health (2022).
[20]
Wong C. L, Holroyd-Leduc J, and et al. Simel D. L. 2010. Does this patient have delirium? Value of bedside instruments.JAMA. 304(7) (2010), 149–156.
[21]
Jiuyong Li, Saisai Ma, Thuc Duy Le, Lin Liu, and Jixue Liu. 2017. Causal Decision Trees. IEEE Transactions on Knowledge and Data Engineering 29(2) (2017).
[22]
Jiuyong Li, Saisai Ma, Thuc Duy Le, Lin Liu, and Jixue Liu. 2019. Causal Decision Trees. The Annals of Statistics 47.2 (2019).
[23]
Siru Liu, Joseph J Schlesinger, Allison B McCoy, Thomas J Reese, Bryan Steitz, Elise Russo, Brian Koh, and Adam Wright. 2023. New onset delirium prediction using machine learning and long short-term memory (LSTM) in electronic health record. Journal of the American Medical Informatics Association 30(1) (2023).
[24]
Michael Lokshin. 2023. The challenges and promises of productive aging. Brookings Commentary (2023).
[25]
Gen Shinozaki MD, Aubrey C. Chan MD PhD, Nicholas A Sparr BA, Kasra Zarei BS, Lindsey N. Gaul BA, Jonathan T. Heinzman BA, Julian Robles BA, Kumi Yuki MD, Theodosis J. Chronis BS, Timothy Ando MD, Terrence Wong MD, Sayeh Sabbagh MSW, Michelle T. Weckmann MD, Sangil Lee MD, Thoru Yamada MD, Matthew D. Karam MD, Nicolas O. Noiseux MD, Eri Shinozaki MD, and John W. Cromwell MD. 2018. Delirium detection by a novel bispectral electroencephalography device in general hospital. Psychiatry and Clinical Neurosciences 72 (8) (2018).
[26]
Robyn P. Thom M.D., Nomi C. Levy-Carrick, M.Phil. Melissa Bui M.D. M.D., and David Silbersweig M.D.2019. Treatment in Psychiatry: Delirium. American Journal of Psychiatry (2019). https://doi.org/10.1176/appi.ajp.2018.18070893
[27]
United Nations. 2017. Department of Economic and Social Affairs. World Population Ageing 2017 Highlights. Report No.: (ST/ESA/SER.A/397). United Nations 2017 (2017).
[28]
Michael Netzer, Werner O Hackl, Michael Schaller, Lisa Alber, Josef Marksteiner, and Elske Ammenwerth. 2020. Evaluating Performance and Interpretability of Machine Learning Methods for Predicting Delirium in Gerontopsychiatric Patients. Stud Health Technol Inform (2020).
[29]
T Numan 2023. Delirium detection using relative delta power based on 1 minute single channel EEG– A multicenter study. British Journal of Anaesthesia (2023).
[30]
Honoria Ocagli, Daniele Bottigliengo, Giulia Lorenzoni, Danila Azzolina, Aslihan S. Acar, Silvia Sorgato, Lucia Stivanello, Mario Degan, and Dario Gregori. 2021. A Machine Learning Approach for Investigating Delirium as a Multifactorial Syndrome. Int J Environ Res Public Health. 18(13) (2021).
[31]
Esther S. Oh, Paul B. Rosenberg, Nae‐Yuh Wang, Frederick E. Sieber, and Karin J. Neufeld. 2022. Delirium detection methodologies: Implications for outcome measurement in clinical trials in postoperative delirium. Int J Geriatr Psychiatry. (2022).
[32]
World Health Organization. 2015. World report on ageing and health.World Health Organization ISBN 978 92 4 069481 1 (2015).
[33]
P. P. et al. Pandharipande. 2013. Long-term cognitive impairment after critical illness. Best Pract Res Clin Anaesthesiol 369 (2013), 1309–1316.
[34]
Nature Comm. QA. 2021. Causality in digital medicine. Nature Communications 12-5471 (2021).
[35]
Neto A. S, Nassar A. P, and Cardoso S. O et al.2012. Delirium screening in critically ill patients.Crit Care Med. 40(6) (2012), 1946–1951.
[36]
Vlada Shevelkova, Calum Mattocks, and Louise Lafortune. 2023. Efforts to address the Sustainable Development Goals in older populations: a scoping review. BMC Public Health (2023).
[37]
Tim L. Wiegand 2022. Electroencephalography in delirium assessment: a scoping review. BMC Neurology (2022).
[38]
J.E. Wilson, M.F. Mart, and C. et al. Cunningham. 2020. Delirium. Nat Rev Dis Primers 6, 90 (2020). https://doi.org/10.1038/s41572-020-00223-4
[39]
Haoran Zhang, Quaid Morris, Berk Ustun, and Maryzeh Ghassemi. 2021. Learning Optimal Predictive Checklists. NeurIPS (2021).

Index Terms

  1. Interpretable Checklist for Delirium Detection

    Recommendations

    Comments

    Information & Contributors

    Information

    Published In

    cover image ACM Conferences
    COMPASS '24: Proceedings of the 7th ACM SIGCAS/SIGCHI Conference on Computing and Sustainable Societies
    July 2024
    354 pages
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than the author(s) must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected].

    Sponsors

    Publisher

    Association for Computing Machinery

    New York, NY, United States

    Publication History

    Published: 28 August 2024

    Permissions

    Request permissions for this article.

    Check for updates

    Author Tags

    1. checklist
    2. delirium
    3. interpretability
    4. machine learning

    Qualifiers

    • Short-paper
    • Research
    • Refereed limited

    Conference

    COMPASS '24
    Sponsor:

    Acceptance Rates

    Overall Acceptance Rate 25 of 50 submissions, 50%

    Upcoming Conference

    COMPASS '25

    Contributors

    Other Metrics

    Bibliometrics & Citations

    Bibliometrics

    Article Metrics

    • 0
      Total Citations
    • 93
      Total Downloads
    • Downloads (Last 12 months)93
    • Downloads (Last 6 weeks)25
    Reflects downloads up to 06 Jan 2025

    Other Metrics

    Citations

    View Options

    View options

    PDF

    View or Download as a PDF file.

    PDF

    eReader

    View online with eReader.

    eReader

    HTML Format

    View this article in HTML Format.

    HTML Format

    Login options

    Media

    Figures

    Other

    Tables

    Share

    Share

    Share this Publication link

    Share on social media