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Illuminating the dark matter of shotgun proteomics

Nature Biotechnology volume 33, pages 717–718 (2015)Cite this article

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Many of the unassignable spectra in proteomics data represent peptides with post-translational modifications.

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Figure 1: Illustration of the benefits of an open search strategy, as used to identify 184,000 modified peptides.

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Authors and Affiliations

  1. Owen S. Skinner and Neil L. Kelleher are at the Department of Chemistry, Northwestern University, Evanston, Illinois, USA.,

    Owen S Skinner & Neil L Kelleher

  2. Neil L. Kelleher is also at the Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.,

    Neil L Kelleher

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  1. Owen S Skinner
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  2. Neil L Kelleher
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Correspondence to Neil L Kelleher.

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Skinner, O., Kelleher, N. Illuminating the dark matter of shotgun proteomics. Nat Biotechnol 33, 717–718 (2015). https://doi.org/10.1038/nbt.3287

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