Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE) hat dies direkt geteilt
Excited to share the recent work from #TeamNDF out today in @Lsajournal! https://lnkd.in/dE9yG4Uz Work led to the finish by Robert Chesters and Jiajie Zhu, supported by many team members and kickstarted way back at the beginning by Beth Coull. Proud of the teamwork and effort that went to putting this together! Thanks to all coauthors (Selma Yagoub, David Baidoe-Ansah, Lídia Cantacorps Centellas, Niklas, Daniel, Katrin, and students Lydia, Lea, Seve and Anneke)! Here we explore how fasting changes the brain activity responses in a region called the paraventricular nucleus of the thalamus. We probed how these changes were specific to MC3R neurons which we found to be highly expressed in this nucleus. Then by using chemogenetics, we found that although hyper activation of the neurons during the fasting period (by giving CNO) did not change the physiological response to fasting, that when the animals were allowed to refeed, they showed an interesting response and behavior towards food. while their consumption didn't change, they became hyperfocused on the food, spending more time interacting with it. We are very interested to know how the melanocortin system may be involved in this changing food attention and how this might effect long term feeding behaviors! Thanks to the support of the Leibniz Association, the Charité - Universitätsmedizin Berlin (NeuroCure), the German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung, DZD) and the German Institute of Human Nutrition for the support along the way! Without each of these institutions and funding bodies, this work wouldn’t have been possible!