TRIM21

TRIM21
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IWG
Dynodwyr
Cyfenwau	TRIM21, RNF81, RO52, Ro/SSA, SSA, SSA1, tripartite motif containing 21, Tripartite motif-containing protein 21
Dynodwyr allanol	OMIM: 109092 HomoloGene: 2365 GeneCards: TRIM21
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • RNA binding • identical protein binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity Cydrannau o'r gell • cytoplasm • cytosol • SCF ubiquitin ligase complex • P-body • intracellular anatomical structure • autophagosome • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • nucleoplasm • ribonucleoprotein complex Prosesau biolegol • negative regulation of protein deubiquitination • response to interferon-gamma • positive regulation of autophagy • interferon-gamma-mediated signaling pathway • protein trimerization • positive regulation of viral entry into host cell • positive regulation of DNA-binding transcription factor activity • protein monoubiquitination • regulation of type I interferon production • positive regulation of cell cycle • protein destabilization • protein ubiquitination • cell cycle • negative regulation of NF-kappaB transcription factor activity • protein autoubiquitination • innate immune response • protein polyubiquitination • negative regulation of viral transcription Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6737	n/a
Ensembl	ENSG00000132109	n/a
UniProt	P19474	n/a
RefSeq (mRNA)	NM_003141	n/a
RefSeq (protein)	NP_003132	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRIM21 yw TRIM21 a elwir hefyd yn Tripartite motif containing 21 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.4.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRIM21.

• SSA
• RO52
• SSA1
• RNF81
• Ro/SSA

Llyfryddiaeth

• "Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. ". Proc Natl Acad Sci U S A. 2015. PMID 26150489.
• "Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers. ". Tumour Biol. 2015. PMID 26055142.
• "Ro52/TRIM21-deficient expression and function in different subsets of peripheral blood mononuclear cells is associated with a proinflammatory cytokine response in patients with idiopathic inflammatory myopathies. ". Clin Exp Immunol. 2017. PMID 27936488.
• "Alterations of TRIM21-mRNA expression during monocyte maturation. ". Immunobiology. 2017. PMID 27773663.
• "Monospecific anti-Ro52/TRIM21 antibodies in a tri-nation cohort of 1574 systemic sclerosis subjects: evidence of an association with interstitial lung disease and worse survival.". Clin Exp Rheumatol. 2015. PMID 26315678.