IL11

IL11
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4MHL
Dynodwyr
Cyfenwau	IL11, AGIF, IL-11, interleukin 11
Dynodwyr allanol	OMIM: 147681 HomoloGene: 535 GeneCards: IL11
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• growth factor activity; • interleukin-11 receptor binding; • cytokine activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • extracellular space; • extracellular region;
Prosesau biolegol	• negative regulation of endothelial cell apoptotic process; • positive regulation of MAPK cascade; • positive regulation of peptidyl-serine phosphorylation; • B cell differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of hormone secretion; • positive regulation of peptidyl-tyrosine phosphorylation; • fat cell differentiation; • positive regulation of cell population proliferation; • regulation of complement-dependent cytotoxicity; • megakaryocyte differentiation; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • cardiovascular fibrosis;
	Sources:Amigo / QuickGO
Orthologau
	3589
	n/a
	ENSG00000095752
	n/a
	P20809
	n/a
	NM_001267718; NM_000641
	n/a
	NP_000632; NP_001254647
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL11 yw IL11 a elwir hefyd yn Interleukin 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.42.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL11.

AGIF
IL-11

Llyfryddiaeth

"RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP). ". Int Immunopharmacol. 2016. PMID 27235596.
"IL-11 in multiple sclerosis. ". Oncotarget. 2015. PMID 26452137.
"Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study. ". Cytokine. 2015. PMID 26276375.
"Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer. ". Cytokine Growth Factor Rev. 2015. PMID 26209885.
"Genetic variants of IL-11 associated with risk of Hirschsprung disease.". Neurogastroenterol Motil. 2015. PMID 26172388.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL11 - Cronfa NCBI

[1]

[2]