CFLAR

CFLAR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3H11, 3H13, 2N5R
Dynodwyr
Cyfenwau	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
Dynodwyr allanol	OMIM: 603599 HomoloGene: 7652 GeneCards: CFLAR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • GO:0001948, GO:0016582 protein binding • cysteine-type endopeptidase activity involved in execution phase of apoptosis • GO:0010577 enzyme activator activity • cysteine-type endopeptidase activity • peptidase activator activity • protein heterodimerization activity • protease binding • death receptor binding • GO:0032403 protein-containing complex binding • cysteine-type endopeptidase activity involved in apoptotic process Cydrannau o'r gell • cytosol • CD95 death-inducing signaling complex • ripoptosome • death-inducing signaling complex • membrane raft • cytoplasm Prosesau biolegol • regulation of apoptotic process • execution phase of apoptosis • negative regulation of apoptotic process • proteolysis • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of necroptotic process • regulation of extrinsic apoptotic signaling pathway via death domain receptors • GO:0022415 viral process • GO:0097285 apoptotic process • GO:0048554 positive regulation of catalytic activity • response to hypoxia • negative regulation of cardiac muscle cell apoptotic process • positive regulation of neuron projection development • cellular response to insulin stimulus • response to testosterone • positive regulation of ERK1 and ERK2 cascade • cellular response to epidermal growth factor stimulus • cellular response to estradiol stimulus • cellular response to hypoxia • cellular response to dexamethasone stimulus • cellular response to nitric oxide • positive regulation of glomerular mesangial cell proliferation • positive regulation of extracellular matrix organization • negative regulation of reactive oxygen species biosynthetic process • negative regulation of cellular response to transforming growth factor beta stimulus • negative regulation of hepatocyte apoptotic process • negative regulation of epithelial cell apoptotic process • positive regulation of hepatocyte proliferation • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • skeletal muscle tissue development • positive regulation of peptidase activity • skeletal muscle atrophy • regulation of skeletal muscle satellite cell proliferation • skeletal myofibril assembly • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • negative regulation of necroptotic process • negative regulation of myoblast fusion • negative regulation of extrinsic apoptotic signaling pathway • response to bacterium Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8837	n/a
Ensembl	ENSG00000003402	n/a
UniProt	O15519	n/a
RefSeq (mRNA)	NM_001127183 NM_001127184 NM_001202515 NM_001202516 NM_001202517 NM_001202518 NM_001202519 NM_001308042 NM_001308043 NM_003879 NM_001351590 NM_001351591 NM_001351592 NM_001351593 NM_001351594	n/a
RefSeq (protein)	NP_001120655 NP_001120656 NP_001189444 NP_001189445 NP_001189446 NP_001189447 NP_001189448 NP_001294971 NP_001294972 NP_003870 NP_001338519 NP_001338520 NP_001338521 NP_001338522 NP_001338523	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CFLAR yw CFLAR a elwir hefyd yn CASP8 and FADD like apoptosis regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CFLAR.

• CASH
• FLIP
• MRIT
• CLARP
• FLAME
• Casper
• FLAME1
• c-FLIP
• FLAME-1
• I-FLICE
• c-FLIPL
• c-FLIPR
• c-FLIPS
• CASP8AP1

Llyfryddiaeth

• "Decreased Expression of SRSF2 Splicing Factor Inhibits Apoptotic Pathways in Renal Cancer. ". Int J Mol Sci. 2016. PMID 27690003.
• "Suppression of c‑FLIPL promotes JNK activation in malignant melanoma cells. ". Mol Med Rep. 2016. PMID 26847085.
• "Evaluation of (fli:GFP) Casper Zebrafish Embryos as a Model for Human Conjunctival Melanoma. ". Invest Ophthalmol Vis Sci. 2017. PMID 29204645.
• "Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium. ". Int J Cancer. 2017. PMID 28670784.
• "Short form FLICE-inhibitory protein promotes TNFα-induced necroptosis in fibroblasts derived from CFLARs transgenic mice.". Biochem Biophys Res Commun. 2016. PMID 27721066.