FOXO1

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXO1 yw FOXO1 a elwir hefyd yn Forkhead box O1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q14.11.

FOXO1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3CO6, 3CO7, 3COA, 4LG0
Dynodwyr
Cyfenwau	FOXO1, FKH1, FKHR, FOXO1A, forkhead box O1
Dynodwyr allanol	OMIM: 136533 HomoloGene: 1527 GeneCards: FOXO1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • beta-catenin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • chromatin binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • protein phosphatase 2A binding • ubiquitin protein ligase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription coactivator binding Cydrannau o'r gell • cytoplasm • cytosol • nucleoplasm • mitocondria • cnewyllyn cell Prosesau biolegol • GO:1901047 insulin receptor signaling pathway • negative regulation of fat cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1903364 positive regulation of protein catabolic process • glucose homeostasis • positive regulation of autophagy • cellular glucose homeostasis • cellular response to hyperoxia • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to starvation • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:1904489 regulation of reactive oxygen species metabolic process • transcription, DNA-templated • regulation of neural precursor cell proliferation • cellular response to dexamethasone stimulus • cellular response to DNA damage stimulus • neuronal stem cell population maintenance • autophagy • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to insulin • blood vessel development • cellular response to cold • response to fluoride • regulation of cell population proliferation • cellular response to insulin stimulus • positive regulation of apoptotic process • negative regulation of stress-activated MAPK cascade • cellular response to oxidative stress • enamel mineralization • cellular response to nitric oxide • positive regulation of gluconeogenesis • temperature homeostasis • GO:0045996 negative regulation of transcription, DNA-templated • fat cell differentiation • negative regulation of canonical Wnt signaling pathway • endocrine pancreas development • protein acetylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to hydrogen peroxide • GO:0097285 apoptotic process • anatomical structure morphogenesis • cell differentiation • negative regulation of cardiac muscle hypertrophy in response to stress • cytokine-mediated signaling pathway • energy homeostasis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2308	n/a
Ensembl	ENSG00000150907	n/a
UniProt	Q12778	n/a
RefSeq (mRNA)	NM_002015	n/a
RefSeq (protein)	NP_002006	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXO1.

• FKH1
• FKHR
• FOXO1A

Llyfryddiaeth

• "A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program. ". Blood. 2017. PMID 28710059.
• "Transcription factor FOXO1 promotes cell migration toward exogenous ATP via controlling P2Y1 receptor expression in lymphatic endothelial cells. ". Biochem Biophys Res Commun. 2017. PMID 28559138.
• "Forkhead Protein FoxO1 Acts as a Repressor to Inhibit Cell Differentiation in Human Fetal Pancreatic Progenitor Cells. ". J Diabetes Res. 2017. PMID 28349071.
• "Upregulation of FoxO 1 Signaling Mediates the Proinflammatory Cytokine Upregulation in the Macrophage from Polycystic Ovary Syndrome Patients. ". Clin Lab. 2017. PMID 28182362.
• "Dysregulation of In Vitro Decidualization of Human Endometrial Stromal Cells by Insulin via Transcriptional Inhibition of Forkhead Box Protein O1.". PLoS One. 2017. PMID 28135285.