FLT1

Protein sy'n cael ei godio yn y corff dynol gan y genyn FLT1 yw FLT1 a elwir hefyd yn Fms related tyrosine kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q12.3.

FLT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3
Dynodwyr
Cyfenwau	FLT1, FLT, FLT-1, VEGFR-1, VEGFR1, fms related tyrosine kinase 1, vascular endothelial growth factor receptor 1, fms related receptor tyrosine kinase 1
Dynodwyr allanol	OMIM: 165070 HomoloGene: 134179 GeneCards: FLT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • vascular endothelial growth factor-activated receptor activity • transferase activity • nucleotide binding • protein kinase activity • placental growth factor-activated receptor activity • kinase activity • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • growth factor binding • vascular endothelial growth factor binding Cydrannau o'r gell • cytoplasm • integral component of membrane • endosome • focal adhesion • bilen • receptor complex • integral component of plasma membrane • extracellular region • extracellular space • Cellbilen • actin cytoskeleton Prosesau biolegol • positive regulation of vascular endothelial growth factor receptor signaling pathway • cell differentiation • blood vessel morphogenesis • vascular endothelial growth factor receptor-1 signaling pathway • positive regulation of MAP kinase activity • monocyte chemotaxis • positive regulation of phospholipase C activity • transmembrane receptor protein tyrosine kinase signaling pathway • vascular endothelial growth factor signaling pathway • phosphorylation • positive regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase activity • multicellular organism development • chemotaxis • protein phosphorylation • vascular endothelial growth factor receptor signaling pathway • embryonic morphogenesis • angiogenesis • protein autophosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cellular response to vascular endothelial growth factor stimulus • cell migration • positive regulation of MAPK cascade • positive regulation of cell population proliferation • positive regulation of cell migration • sprouting angiogenesis • positive regulation of ERK1 and ERK2 cascade • negative regulation of vascular endothelial cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2321	n/a
Ensembl	ENSG00000102755	n/a
UniProt	P17948	n/a
RefSeq (mRNA)	NM_001159920 NM_001160030 NM_001160031 NM_002019	n/a
RefSeq (protein)	NP_001153392 NP_001153502 NP_001153503 NP_002010	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FLT1.

• FLT
• FLT-1
• VEGFR1
• VEGFR-1

Llyfryddiaeth

• "Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. ". PLoS One. 2017. PMID 28817576.
• "Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population. ". Hypertension. 2017. PMID 28652462.
• "Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. ". Nat Genet. 2017. PMID 28628106.
• "sFLT-1 inhibits proliferation, migration, and invasion of colorectal cancer SW480 cells through vascular mimicry formation suppression. ". Tumour Biol. 2017. PMID 28468595.
• "FLT-1 gene polymorphisms and protein expression profile in rheumatoid arthritis.". PLoS One. 2017. PMID 28323906.