Aurora Biomed Inc.

Achieve precise, efficient trace element analysis with Aurora's Atomic Absorption Spectrometers. Power up your lab with Aurora’s advanced technology!

🚀 Boost Your Lab’s Efficiency with the VERSA1100! 🚀 From optimizing complex NGS Library Plate Prep and Differential Digestion setup to executing routine Quantification and Amplification Plate Prep setup tasks with precision, the VERSA1100 Automated Liquid Handling Workstation is the ultimate adaptable solution. This powerhouse evolves to meet your lab's unique needs, delivering both accuracy and flexibility for any protocol. 💡 Ready to unlock new potential in your lab? Discover how the VERSA1100 can empower your scientific breakthroughs! 🔬 𝐑𝐞𝐚𝐝 𝐁𝐥𝐨𝐠 𝐡𝐞𝐫𝐞: https://lnkd.in/g6eiHYvZ #AutomatedLab #NGS #LiquidHandling #LabAutomation #InnovationInScience #EfficiencyInResearch #LabSolutions #VERSA1100

👻 Frightfully Precise Pipetting – No Shaky Hands In The Premise! 👻 At the haunted labs of Aurora Biomed, lies the unequivocal VERSA liquid handling series. Do not be mistaken by its compact design, as it will get the job done, and without a doubt, leave no dead volumes behind ☠. These automated systems dispense liquids with bone-chilling accuracy, leaving no room for the shivers or shaky hands of mere mortals. Every sample is handled with precision that would make even the Headless Horseman nod in approval! Come take a peek at the VERSA Series Brochure, If you dare: https://lnkd.in/gk2e7PUz

Sodium-dependent glucose transporter 2 (#SGLT2, encoded by the #SLC5A2 gene) inhibitors such as dapagliflozin or empagliflozin are known for their hypoglycemic effect through increased urinary excretion of glucose. Additionally, although less understood, their cardio-protective effects are linked to reduced blood pressure. Dapagliflozin was originally approved by the FDA in 2014 to improve glycemic control in adults with type 2 diabetes in conjunction with diet and exercise. In 2021, the FDA approved dapagliflozin to reduce the risk of kidney function decline, kidney failure, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease who are at risk of disease progression. The present study aims to better understand the mechanisms associated with SLGT2 inhibitors-induced relaxation of arteries. 𝐈𝐭 𝐫𝐞𝐯𝐞𝐚𝐥𝐬 𝐭𝐡𝐚𝐭 𝐭𝐡𝐞 𝐫𝐞𝐥𝐚𝐱𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐚𝐫𝐭𝐞𝐫𝐢𝐞𝐬 𝐫𝐞𝐬𝐮𝐥𝐭𝐬 𝐟𝐫𝐨𝐦 𝐫𝐞𝐥𝐞𝐚𝐬𝐢𝐧𝐠 𝐜𝐚𝐥𝐜𝐢𝐭𝐨𝐧𝐢𝐧 𝐠𝐞𝐧𝐞-𝐫𝐞𝐥𝐚𝐭𝐞𝐝 𝐩𝐞𝐩𝐭𝐢𝐝𝐞 (𝐂𝐆𝐑𝐏) 𝐟𝐫𝐨𝐦 𝐬𝐞𝐧𝐬𝐨𝐫𝐲 𝐧𝐞𝐫𝐯𝐞𝐬 𝐢𝐧 𝐚 𝐬𝐨𝐝𝐢𝐮𝐦/𝐡𝐲𝐝𝐫𝐨𝐠𝐞𝐧 𝐞𝐱𝐜𝐡𝐚𝐧𝐠𝐞𝐫𝐬 (𝐍𝐇𝐄1)-𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐭 𝐦𝐚𝐧𝐧𝐞𝐫. Combining a pharmacological approach and various techniques including immunohistochemistry, immunocytochemistry, and electrophysiology techniques, the authors shed some light on the underlying mechanism of 𝐒𝐆𝐋𝐓2 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫-𝐢𝐧𝐝𝐮𝐜𝐞𝐝 𝐫𝐞𝐥𝐚𝐱𝐚𝐭𝐢𝐨𝐧 in mesenteric arteries and identified the role of CGRP release from sensory nerves secondary to NHE1 inhibition. Overall, this paper underscores the sheer importance of ion channels, #transporters, and #exchangers across various disease areas. Highlighting the importance of expanding the work in the ion channel field.   Publication DOI: https://lnkd.in/gxJSWr3w Authors: Elizabeth Forrester, Miguel Benítez-Angeles , Kaitlyn Redford, Tamara Rosenbaum, Geoffrey W Abbott, Vincenzo Barrese, Kim Dora, Anthony Albert, Johs Dannesboe,Isabelle Salles-Crawley, Thomas Jepps, Iain Greenwood It's worth noting that NHE1 is an 𝐞𝐥𝐞𝐜𝐭𝐫𝐨𝐧𝐞𝐮𝐭𝐫𝐚𝐥 𝐭𝐫𝐚𝐧𝐬𝐩𝐨𝐫𝐭𝐞𝐫, making studies against this target more challenging through electrophysiology-based methods. 𝐈𝐨𝐧 𝐂𝐡𝐚𝐧𝐧𝐞𝐥 𝐑𝐞𝐚𝐝𝐞𝐫𝐬 (𝐈𝐂𝐑𝐬) are well-equipped for measuring the activity of targets that don't generate a net charge difference across the membrane. Read about ICRs here: https://lnkd.in/gG3GxCdB   #IonChannel #CoTransporter #TRP #Kv7 #CGRP #SGLT2Inhibitors #ICR

🔍 Solving Cold Cases with the ForenSeq Kintelligence Kit!   The ForenSeq Kintelligence Kit is enabling precise kinship analysis and human identification in forensic investigations. Its advanced SNP analysis allows for identifying distant relatives, even from degraded DNA samples. This technology supports investigative genetic genealogy IGG, providing crucial leads in cold cases. This powerful combination enhances our ability to uncover the truth and bring justice to victims!   🧬 Have you had a chance to read the validation study on FGG for NGS investigations? The VERSA1100 has been validated by Verogen (Now a QIAGEN company) for ForenSeq DNA Signature Prep kit, ForenSeq Kintelligence Kit and the ForenSeq mtDNA Whole Genome Kit workflow. 𝐑𝐞𝐚𝐝 𝐯𝐚𝐥𝐢𝐝𝐚𝐭𝐢𝐨𝐧: https://lnkd.in/gtaywJWb 𝐑𝐞𝐚𝐝 𝐚𝐛𝐨𝐮𝐭 𝐕𝐄𝐑𝐒𝐀 1100: https://lnkd.in/gqNBp4Xx   #Forensics #ColdCases #DNA #IGG #ForenSeq #Justice #CrimeSolving

Aurora Biomed Inc.

Have you heard about this trace elemental analysis equipment for mercury and other hydride-forming elements? Come take a look! 😮

Ensuring Food and Water Safety: Measuring Methylmercury Levels in Marine Fish with the LUMINA 3300 Atomic Fluorescence Spectrometer   Trace elemental analysis, particularly for mercury levels, is an imperative component for food and water safety. Marine fish accumulate methylmercury (MeHg) to high concentrations, a neurotoxic compound known to affect animal behaviour and potentially resulting in population-level effects.   In this publication, from Stony Brook University titled “Effects of methylmercury on the early life stages of an estuarine forage fish using two different dietary sources”, MeHg levels were measured by the LUMINA 3300 Atomic Fluorescence Spectrometer (AFS) known for its reliability in detecting 𝐩𝐚𝐫𝐭𝐬-𝐩𝐞𝐫-𝐭𝐫𝐢𝐥𝐥𝐢𝐨𝐧 levels of elements superior to that of other mercury analyzers.   Interested in learning more? Check the publication and LUMINA 3300 AFS features below: - 𝐏𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: https://lnkd.in/guQmxbeh  - 𝐋𝐔𝐌𝐈𝐍𝐀 3300 𝐀𝐅𝐒 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐬: https://lnkd.in/g2tVkdEW   𝐀𝐮𝐭𝐡𝐨𝐫𝐬: Xiayan Ye, Ph.D., Konstantine John Rountos, Cheng-Shiuan Lee, Nicholas S. Fischer   #ElementalAnalysis #MeHg #Methylmercury #AFS #AtomicFluorescenceSpectrometer #watersafety #water #aquaticbiology #behaviouralecology #wastemanagement #agriculture #EIA #EnvironmentalImpactAssessment #StonyBrookUniversity

Seasonal influenza viruses are estimated to cause between 290,000 and 650,000 deaths globally each year.   Findings from a group of scientists at Yale University, Scripps Research, Washington University in St. Louis, and Icahn School of Medicine at Mount Sinai conducted the present study. Their research suggested that vaccinating humans against the influenza virus can trigger a germinal center (GC) response, which increases the likelihood of generating B cell clones that target new viral epitopes. This broadens the spectrum of protective antibodies produced by the vaccine, providing enhanced immunity against this rapidly evolving virus.   𝐒𝐭𝐮𝐝𝐲 𝐎𝐯𝐞𝐫𝐯𝐢𝐞𝐰: The study was done on healthy young adults who received a seasonal influenza vaccine. Blood and lymph node samples were collected before vaccination and at intervals of 1, 2, approximately 4, and 9 weeks post-vaccination. Researchers analyzed antibodies that bind to the influenza vaccine, identifying both broadly reactive (targeting multiple strains) and strain-specific antibodies.   In the methodology, the automated 𝐕𝐄𝐑𝐒𝐀 𝐥𝐢𝐪𝐮𝐢𝐝 𝐡𝐚𝐧𝐝𝐥𝐞𝐫 was used to spot recombinant influenza virus hemagglutinins (HAs) onto glass slides, creating microarrays to study how various antibodies interact with influenza virus proteins. This involved dispensing precise 30-nanoliter volumes of protein solution, ensuring uniform spot size and concentration for reproducibility and reliability. After the viral proteins were spotted, blocking antibodies were applied, followed by several washing steps. A fluorescently labeled secondary antibody (Cy5) was then added to assess how antibodies interacted with the viral proteins.   Following a series of tests, researchers concluded that influenza vaccination can stimulate lymph node responses, promoting the development of new B cell clones that target different parts of the virus.   This discovery could pave the way for developing vaccines that generate a broader range of protective antibodies, enhancing defense against the ever-changing influenza virus.     𝐒𝐞𝐞 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: https://lnkd.in/gfzUnYnc   #InfluenzaResearch #VaccineDevelopment #PublicHealth #Immunology #SeasonalFlu #BCellResponse #AntibodyResponse #InfecitousDiseases #ViralImmunity #Fluseason #FluVaccine #VERSA #LiquidHandling #Automation

𝐈𝐭𝐬 𝐐&𝐀 𝐭𝐢𝐦𝐞! 𝐖𝐡𝐚𝐭’𝐬 𝐭𝐡𝐢𝐬 𝐦𝐨𝐧𝐭𝐡𝐬 𝐛𝐮𝐫𝐧𝐢𝐧𝐠 𝐪𝐮𝐞𝐬𝐭𝐢𝐨𝐧 𝐨𝐧? 𝘞𝘩𝘺, 𝘢𝘯𝘥 𝘩𝘰𝘸 𝘵𝘰 𝘥𝘦𝘵𝘦𝘳𝘮𝘪𝘯𝘦 𝘩𝘌𝘙𝘎 𝘪𝘯𝘩𝘪𝘣𝘪𝘵𝘪𝘰𝘯? The human ether-a-go-go related gene (#hERG) potassium channel is encoded by the #KCNH2 gene and conducts the rapid delayed rectifier potassium current (#IKr) in human cardiomyocytes. IKr is an important contributor to the repolarization phase of the cardiac action potential. Drug-induced inhibition of IKr increases the action potential duration, resulting in prolonged QT interval on the surface electrocardiogram. QT prolongation can lead to Torsades de Pointe (#TdP) that can degenerate into ventricular fibrillation and sudden cardiac death. Importantly, hERG channels are particularly prone to block by compounds with diverse chemical structures because of unique structural properties: 1) Large volume of the pore inner vestibule which favors drug entry 2) Presence of two aromatic residues in the S6 domain which promotes binding with drugs containing aromatic moieties through pie electron stacking. Aurora Biomed offers services for measuring drug-induced inhibition of hERG channels using the rubidium flux assay in combination with manual patch clamp, following best practice considerations described in ICH E14/S7B Q&As. Email us at [email protected] with more questions and let’s dive into some insightful answers together! #hERG #AssayServices #QTProlongation #ICR #Labelfree #Electrophysiology #PatchClamp #CardiacSafety