ARL6IP1

ARL6IP1
Identifikatori
Aliasi	ARL6IP1
Vanjski ID-jevi	OMIM: 607669 MGI: 1858943 HomoloGene: 41008 GeneCards: ARL6IP1
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	18,801,572 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	117,728,885 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina;
Ćelijska komponenta	• citoplazma; • citosol; • membrana; • Sec61 translocon complex; • Endoplazmatski retikulum; • Endomembranski sistem; • endoplasmic reticulum membrane; • integral component of endoplasmic reticulum membrane; • integral component of membrane;
Biološki proces	• cotranslational protein targeting to membrane; • endoplasmic reticulum tubular network formation; • GO:0097285 apoptoza; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • endoplasmic reticulum tubular network membrane organization; • negative regulation of apoptotic process; • positive regulation of L-glutamate import across plasma membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	23204
	54208
	ENSG00000170540
	ENSMUSG00000030654
	Q15041
	Q9JKW0
	NM_015161; NM_001313858
	NM_019419
	NP_001300787; NP_055976
	NP_062292
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ADP-ribozilacijski faktoroliki protein 1 koji komunicira sa proteinom 6 jest protein koji je kod ljudi kodiran genom ARL6IP1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 203 aminokiseline, a molekulska težina 23.363 Da.^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin

P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAEGDNRSTN	LLAAETASLE	EQLQGWGEVM	LMADKVLRWE	RAWFPPAIMG
VVSLVFLIIY	YLDPSVLSGV	SCFVMFLCLA	DYLVPILAPR	IFGSNKWTTE
QQQRFHEICS	NLVKTRRRAV	GWWKRLFTLK	EEKPKMYFMT	MIVSLAAVAW
VGQQVHNLLL	TYLIVTSLLL	LPGLNQHGII	LKYIGMAKRE	INKLLKQKEK
KNE

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170540 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030654 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1".
^ "UniProt, Q15041". Pristupljeno 1. 7. 2021.

Vanjski linkovi

Lokacija ljudskog genoma ARL6IP1 i stranica sa detaljima o genu ARL6IP1 u UCSC Genome Browseru.

Dopunska literatura

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lui HM, Chen J, Wang L, Naumovski L (2003). "ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis". Mol. Cancer Res. 1 (7): 508–18. PMID 12754298.
Pettersson M, Bessonova M, Gu HF, Groop LC, Jönsson JI (2000). "Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)". Genomics. 68 (3): 351–4. doi:10.1006/geno.2000.6278. PMID 10995579.
Ingley E, Williams JH, Walker CE, Tsai S, Colley S, Sayer MS, Tilbrook PA, Sarna M, Beaumont JG, Klinken SP (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919. S2CID 30948975.
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170540 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030654 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1".

[UniProt-6] "UniProt, Q15041". Pristupljeno 1. 7. 2021.

[1]

[2]

[3]

[4]

[5]

[6]