Children's Medical Research Institute

Have you thought about writing your Will? As part of Include a Charity Week, we're offering you the opportunity to write your Will for FREE! 📝 By including a gift in your Will, you play a vital role in helping us create a brighter future where no childhood is impacted by genetic disease. Start your FREE Will today and leave a lasting legacy: https://lnkd.in/gpe7a4dh

Thank you to the Sharpe family for sharing Alessia's inspirational story and the progress in #genetherapy research at Meg Tudehope's #JeansforGenes morning tea.

Our Research Facilities team will be attending the Life as a Clinician-Scientist symposium tomorrow hosted by Australian Academy of Health and Medical Sciences at UNSW. If you're looking to pursue a career as a clinician-scientist, then we recommend you join us at this event! This is your last chance to register. Click here for details: https://lnkd.in/gmYBy3S2

We're thrilled to unveil another lineup of distinguished speakers joining the #ProCan Sydney International Conference: Advancing Multi-Omics into the Clinic. Prof Anna DeFazio is Sydney West Chair in Translational Cancer Research at the University of Sydney, she leads #gynaecologicalcancer research at The Westmead Institute for Medical Research and Westmead Hospital. Prof DeFazio is also Director of the Centre for Cancer Research at WIMR and co-leads the Ovarian Cancer Stream at The Daffodil Centre. Her research on clinico-genomic factors in #ovariancancer treatment is pivotal in advancing that ovarian cancer research. Prof Lois Holloway is a radiation #oncology medical physicist at the Ingham Institute Medical Physics and Liverpool and Macarthur Cancer Therapy centres. She leads a multidisciplinary team focused on using imaging data to improve #cancer care. Prof Holloway has published over 200 peer-reviewed papers and mentored 20+ PhD candidates. She also established the Australian Cancer Data Network, a groundbreaking initiative using iterative machine learning to transform cancer data analysis across Australia. A/Prof Vanessa (Ness) Tyrrell is Head of the Clinical Translation Research Division and Program Director of the ZERO Childhood Cancer National Precision Medicine Program at Children's Cancer Institute, Ness is pivotal in shaping a sustainable precision medicine platform for paediatric oncology. With over 30 years of expertise in genetic testing and a leader in her field, Ness's contributions are transforming research-driven #clinical care. Prof Zornitza Stark is a #clinicalgeneticist at Victorian Clinical Genetics Services (VCGS) for Australian Genomics. Prof Stark is dedicated to integrating genomic testing into healthcare, especially for diagnosing rare diseases in children. Since 2014, she's led key projects with Melbourne Genomics and Australian Genomics, driving advancements in rare disease diagnosis. These experts will share their groundbreaking insights in #medicalresearch and #clinicalresearch. Learn more: https://lnkd.in/gbfiaDzu

Dr Kate Mullany is as dedicated as they come. As a paediatrician, she is able to tell patients what’s wrong, but she can’t always offer a treatment or cure. So instead, she’s now in our gene therapy lab finding those cures herself. “I’m just one researcher, but I’m one researcher in an incredible team who has the amazing support of the Australian public allowing us to do life-changing research,” says Kate.

Our researchers left the lab to inspire hundreds of kids and their families with fun science facts and activities like our popular comic spreads. Many were shocked to hear that our bodies have two trillion cells! Thank you to the Australian Museum for having us again this year for their Sydney Science Trail Expo. If you missed the event, you can still explore all the resources here: https://lnkd.in/gDVBWYw9

Congratulations to the #CMRI ProCan® team on their latest publication. This research delves into the optimisation of proteomics and phosphoproteomic #biomarker studies using formalin-fixed paraffin-embedded (FFPE) tissues. The team compared four methods to remove the wax and rehydrate these samples and evaluated five extraction methods to identify the most effective approaches for #FFPE tissue analysis by proteomics. They revealed that the Heat n’ Beat method (developed in ProCan®) is the fastest and most reproducible for general protein analysis, while the S-Trap method delivers the highest peptide yield. For phosphopeptide enrichment, TFE stands out as the most efficient. The study highlights ongoing challenges in quantifying FFPE-derived peptides, such as biases in UV and fluorescence assays, and offers tailored recommendations for method selection based on specific research needs. By providing a clear set of optimised methods, this research significantly advances the accuracy and reproducibility of biomarker studies. It brings us closer to unlocking the full potential of FFPE tissues in proteomics for cancer, paving the way for their future clinical application in diagnostics and treatment strategies. You can read the full publication here: https://lnkd.in/gkvebQrQ

Up until the 30th Sept, take advantage of our Pilot Study Package with no minimum sample requirement and receive preliminary bioinformatic analysis. This unique opportunity at our Single Cells Analytics Facility will help enhance your research with Single Cell Transcriptomics! The package includes: - Cell counts and viability processing - Cell isolation and barcoding with GEM technology - Post GEM RT Cleanup and cDNA amplification - Gene Expression Library Construction Preliminary Data Analysis: - Multiplexing multiple samples in a single reaction - Mapping reads to the reference genome - QC Reports - Filtered processed counts - De-multiplexing (if needed) Experiments must be completed by 30th April 2025. Limited availability—don't miss out! Learn more here: https://lnkd.in/g-XvTdux

As a proud sponsor of the Life as a Clinician-Scientist symposia, we invite you to please join us in meeting leading experts and discover the many pathways to an exciting career in clinical medicine and science.

We are proud to announce more international leaders in #medicalresearch and #clinicalresearch joining the conference as international speakers panel at the #ProCan Sydney International Conference: Advancing Multi-Omics into the Clinic. Dr Bing Zhang, a Professor at Baylor College of Medicine and CPRIT Scholar, renowned for his groundbreaking work in computational cancer #proteogenomics, which earned him the 2023 Gilbert S. Omenn Computational Proteomics Award (US HUPO). With over 180 peer-reviewed papers, Dr Zhang's research integrates genomic and #proteomic data to advance #cancer biology and patient outcomes. Dr Jennifer Van Eyk, PhD, a leading expert in clinical proteomics and the Erika Glazer Endowed Chair in Women’s Heart Health at Cedars-Sinai Medical Center. Dr Van Eyk develops personalised #biomarkers and therapies through advanced protein mass spectrometry, leading the Advanced Clinical BioSystems Research Institute and the Precision Biomarker Laboratories. Prof David Thomas, inaugural Director of the Centre for Molecular Oncology at UNSW and Head of the Genomic Cancer Medicine Laboratory at the Garvan Institute of Medical Research. As CEO of Omico, he leads a national precision medicine program for rare and early-onset cancers. With over 200 research publications, his work focuses on applying genomic technologies to cancer research and management. We are thrilled to host these remarkable industry leaders and be able to share their insights with many other researchers at this event. If you would like learn more about each of them, please tap here: https://lnkd.in/gbfiaDzu