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UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase.
Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O'Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW. Braganza A, et al. J Biol Chem. 2017 Feb 10;292(6):2470-2484. doi: 10.1074/jbc.M116.766824. Epub 2016 Dec 21. J Biol Chem. 2017. PMID: 28003368 Free PMC article.
Recent genome-wide studies found that patients with hypotonia, developmental delay, intellectual disability, congenital anomalies, characteristic facial dysmorphic features, and low cholesterol levels suffer from Kaufman oculocerebrofacial syndrome (KOS, also reported as b …
Recent genome-wide studies found that patients with hypotonia, developmental delay, intellectual disability, congenital anomalies, character …
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.
Schosserer M, Minois N, Angerer TB, Amring M, Dellago H, Harreither E, Calle-Perez A, Pircher A, Gerstl MP, Pfeifenberger S, Brandl C, Sonntagbauer M, Kriegner A, Linder A, Weinhäusel A, Mohr T, Steiger M, Mattanovich D, Rinnerthaler M, Karl T, Sharma S, Entian KD, Kos M, Breitenbach M, Wilson IB, Polacek N, Grillari-Voglauer R, Breitenbach-Koller L, Grillari J. Schosserer M, et al. Nat Commun. 2015 Jan 30;6:6158. doi: 10.1038/ncomms7158. Nat Commun. 2015. PMID: 25635753 Free PMC article.
Morphometric Analysis of Hippocampal and Neocortical Pyramidal Neurons in a Mouse Model of Late Onset Alzheimer's Disease.
Mehder RH, Bennett BM, Andrew RD. Mehder RH, et al. J Alzheimers Dis. 2020;74(4):1069-1083. doi: 10.3233/JAD-191067. J Alzheimers Dis. 2020. PMID: 32144984 Free PMC article.
Compared to WT controls, the morphology and complexity of dCA1 pyramidal neurons from KOs showed significant reductions in apical and basal dendritic length, dendrite intersections, ends, and nodes. ...
Compared to WT controls, the morphology and complexity of dCA1 pyramidal neurons from KOs showed significant reductions in apical and …
Age-Related Neuronal Deterioration Specifically Within the Dorsal CA1 Region of the Hippocampus in a Mouse Model of Late Onset Alzheimer's Disease.
Mehder RH, Bennett BM, Andrew RD. Mehder RH, et al. J Alzheimers Dis. 2021;79(4):1547-1561. doi: 10.3233/JAD-201024. J Alzheimers Dis. 2021. PMID: 33459722 Free PMC article.
RESULTS: The morphology and complexity of dCA1 pyramidal neurons were similar at age 3 months in WTs and KOs. However, by 6 months there were significant reductions in apical and basal dendritic length, dendrite complexity, and spine density in KO versus WT mice that were …
RESULTS: The morphology and complexity of dCA1 pyramidal neurons were similar at age 3 months in WTs and KOs. However, by 6 months th …