Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain
Molecular psychiatry, 2002•nature.com
The use of thyroid hormones as an effective adjunct treatment for affective disorders has
been studied over the past three decades and has been confirmed repeatedly. Interaction of
the thyroid and monoamine neurotransmitter systems has been suggested as a potential
underlying mechanism of action. While catecholamine and thyroid interrelationships have
been reviewed in detail, the serotonin system has been relatively neglected. Thus, the goal
of this article is to review the literature on the relationships between thyroid hormones and …
been studied over the past three decades and has been confirmed repeatedly. Interaction of
the thyroid and monoamine neurotransmitter systems has been suggested as a potential
underlying mechanism of action. While catecholamine and thyroid interrelationships have
been reviewed in detail, the serotonin system has been relatively neglected. Thus, the goal
of this article is to review the literature on the relationships between thyroid hormones and …
Abstract
The use of thyroid hormones as an effective adjunct treatment for affective disorders has been studied over the past three decades and has been confirmed repeatedly. Interaction of the thyroid and monoamine neurotransmitter systems has been suggested as a potential underlying mechanism of action. While catecholamine and thyroid interrelationships have been reviewed in detail, the serotonin system has been relatively neglected. Thus, the goal of this article is to review the literature on the relationships between thyroid hormones and the brain serotonin (5-HT) system, limited to studies in adult humans and adult animals. In humans, neuroendocrine challenge studies in hypothyroid patients have shown a reduced 5-HT responsiveness that is reversible with thyroid replacement therapy. In adult animals with experimentally-induced hypothyroid states, increased 5-HT turnover in the brainstem is consistently reported while decreased cortical 5-HT concentrations and 5-HT 2A receptor density are less frequently observed. In the majority of studies, the effects of thyroid hormone administration in animals with experimentally-induced hypothyroid states include an increase in cortical 5-HT concentrations and a desensitization of autoinhibitory 5-HT 1A receptors in the raphe area, resulting in disinhibition of cortical and hippocampal 5-HT release. Furthermore, there is some indication that thyroid hormones may increase cortical 5-HT 2 receptor sensitivity. In conclusion, there is robust evidence, particularly from animal studies, that the thyroid economy has a modulating impact on the brain serotonin system. Thus it is postulated that one mechanism, among others, through which exogenous thyroid hormones may exert their modulatory effects in affective illness is via an increase in serotonergic neurotransmission, specifically by reducing the sensitivity of 5-HT 1A autoreceptors in the raphe area, and by increasing 5-HT 2 receptor sensitivity.
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