[HTML][HTML] Excellent response of severe aplastic anemia to treatment of gut inflammation: A case report and review of the literature
XC Zhao, L Zhao, XY Sun, ZS Xu, B Ju… - World journal of …, 2020 - ncbi.nlm.nih.gov
XC Zhao, L Zhao, XY Sun, ZS Xu, B Ju, FJ Meng, HG Zhao
World journal of clinical cases, 2020•ncbi.nlm.nih.govBACKGROUND Cumulative evidence suggests that the aberrant immune responses in
acquired aplastic anemia (AA) are sustained by active chronic infections in genetically
susceptible individuals. Recently, the constant source to trigger and sustain the
pathophysiology has been proposed to come from the altered gut microbiota and chronic
intestinal inflammation. In this case, our serendipitous finding provides convincing evidence
that the persistently dysregulated autoimmunity may be generated, at least in a significant …
acquired aplastic anemia (AA) are sustained by active chronic infections in genetically
susceptible individuals. Recently, the constant source to trigger and sustain the
pathophysiology has been proposed to come from the altered gut microbiota and chronic
intestinal inflammation. In this case, our serendipitous finding provides convincing evidence
that the persistently dysregulated autoimmunity may be generated, at least in a significant …
Abstract
BACKGROUND
Cumulative evidence suggests that the aberrant immune responses in acquired aplastic anemia (AA) are sustained by active chronic infections in genetically susceptible individuals. Recently, the constant source to trigger and sustain the pathophysiology has been proposed to come from the altered gut microbiota and chronic intestinal inflammation. In this case, our serendipitous finding provides convincing evidence that the persistently dysregulated autoimmunity may be generated, at least in a significant proposition of AA patients, by the altered gut microbiota and compromised intestinal epithelium.
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