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ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List
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Acta Endocrinologica (Buc)
Trifu S, Vladuti A, Popescu A
Neuroendocrine Aspects of Pregnancy and Postpartum Depression
Acta Endo (Buc) 2019, 15 (3): 410-415doi: 10.4183/aeb.2019.410
Introduction. Ties between the endocrine system
and mental health are undeniably a consistent point of
interest in modern day medicine. Furthermore, mental
disturbances due to hormonal changes following childbirth
have been mentioned in medical literature since Hippocrates.
Considering the dramatic endocrine, paracrine and autocrine
changes that occur during gestation, labour and postnatal
phase, hormonal theories are not to be ignored in the
treatment of postpartum disorders.
Results. Reproductive hormones are known to
modulate behavioural, emotional and cognitive response,
therefore rapid changes in estradiol and progesterone
plasma concentrations during pregnancy and labour create
a vulnerable terrain leading towards postpartum disorders.
New research shows that women suffering from postpartum
disorders have abnormal neural responses, suggesting a
neuroendocrine explanation for postpartum syndromes.
Conclusion. To facilitate further research in this
area, we present new information on several hormonal
interactions and the psychiatric response involved in
pregnancy and labour, offering an interdisciplinary outlook
on pregnancy and postpartum disorders. There is enough
evidence to suggest that estradiol, progesterone, oxytocin,
cortisol and thyroid hormones are some of many hormones
involved in postpartum syndromes and tackling their
perinatal imbalance with pharmacological substituents or
antagonists could be useful as an adjuvant form of treatment
in future patients.
Keywords: pregnancy, labour, postpartum,
estradiol, progesterone, depression
Correspondence: Simona Trifu MD, “Carol Davila” University of Medicine and Pharmacy, Dept. of Neurosciences, 37 Dionisie Lupu
Str., Bucharest 020021, Romania, E-mail: [email protected]